Details for gene set GNF2_FEN1[GSEA]

Table: GSEA Results Summary

Dataset	SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos
Phenotype	SMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class	0
GeneSet	GNF2_FEN1
Enrichment Score (ES)	0.5364209
Normalized Enrichment Score (NES)	1.9170101
Nominal p-value	0.0
FDR q-value	0.21794935
FWER p-Value	0.706

Fig 1: Enrichment plot: GNF2_FEN1   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	GINS1	GINS1 Entrez,  Source	GINS complex subunit 1 (Psf1 homolog)	1800	0.195	-0.0161	Yes
2	TYMS	TYMS Entrez,  Source	thymidylate synthetase	2505	0.150	-0.0020	Yes
3	RAD51AP1	RAD51AP1 Entrez,  Source	RAD51 associated protein 1	2626	0.146	0.0336	Yes
4	POLE2	POLE2 Entrez,  Source	polymerase (DNA directed), epsilon 2 (p59 subunit)	2630	0.146	0.0736	Yes
5	NDC80			3031	0.120	0.0911	Yes
6	TTK	TTK Entrez,  Source	TTK protein kinase	3042	0.119	0.1234	Yes
7	DHFR	DHFR Entrez,  Source	dihydrofolate reductase	3124	0.114	0.1517	Yes
8	SHCBP1	SHCBP1 Entrez,  Source	SHC SH2-domain binding protein 1	3202	0.110	0.1790	Yes
9	PLK4	PLK4 Entrez,  Source	polo-like kinase 4 (Drosophila)	3251	0.108	0.2068	Yes
10	RFC4	RFC4 Entrez,  Source	replication factor C (activator 1) 4, 37kDa	3299	0.105	0.2339	Yes
11	GMNN	GMNN Entrez,  Source	geminin, DNA replication inhibitor	3370	0.102	0.2592	Yes
12	DKC1	DKC1 Entrez,  Source	dyskeratosis congenita 1, dyskerin	3456	0.098	0.2830	Yes
13	VRK1	VRK1 Entrez,  Source	vaccinia related kinase 1	3639	0.091	0.3011	Yes
14	DTL	DTL Entrez,  Source	denticleless homolog (Drosophila)	3696	0.089	0.3234	Yes
15	SMC4	SMC4 Entrez,  Source	structural maintenance of chromosomes 4	3717	0.088	0.3469	Yes
16	DUT	DUT Entrez,  Source	dUTP pyrophosphatase	4087	0.082	0.3553	Yes
17	HAT1	HAT1 Entrez,  Source	histone acetyltransferase 1	4293	0.075	0.3681	Yes
18	DTYMK	DTYMK Entrez,  Source	deoxythymidylate kinase (thymidylate kinase)	4302	0.075	0.3886	Yes
19	CCNA2	CCNA2 Entrez,  Source	cyclin A2	7999	0.073	0.2657	Yes
20	E2F8	E2F8 Entrez,  Source	E2F transcription factor 8	8004	0.073	0.2856	Yes
21	NUSAP1	NUSAP1 Entrez,  Source	nucleolar and spindle associated protein 1	8179	0.071	0.2983	Yes
22	DLGAP5			8319	0.068	0.3116	Yes
23	CDK1			8548	0.063	0.3201	Yes
24	MCM4	MCM4 Entrez,  Source	MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)	8582	0.062	0.3359	Yes
25	DNAJC9	DNAJC9 Entrez,  Source	DnaJ (Hsp40) homolog, subfamily C, member 9	8623	0.061	0.3512	Yes
26	KIF18B			8919	0.060	0.3562	Yes
27	MCM5	MCM5 Entrez,  Source	MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	9075	0.057	0.3659	Yes
28	SNRPD1	SNRPD1 Entrez,  Source	small nuclear ribonucleoprotein D1 polypeptide 16kDa	9105	0.056	0.3803	Yes
29	HNRNPAB			9112	0.056	0.3955	Yes
30	RRM1	RRM1 Entrez,  Source	ribonucleotide reductase M1 polypeptide	9137	0.056	0.4099	Yes
31	COPS3	COPS3 Entrez,  Source	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	9146	0.056	0.4248	Yes
32	HMMR	HMMR Entrez,  Source	hyaluronan-mediated motility receptor (RHAMM)	9173	0.055	0.4390	Yes
33	RACGAP1	RACGAP1 Entrez,  Source	Rac GTPase activating protein 1	9253	0.055	0.4509	Yes
34	TOP2A	TOP2A Entrez,  Source	topoisomerase (DNA) II alpha 170kDa	9270	0.054	0.4652	Yes
35	CCNB2	CCNB2 Entrez,  Source	cyclin B2	9453	0.051	0.4723	Yes
36	MSH2	MSH2 Entrez,  Source	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	9516	0.050	0.4837	Yes
37	MCM3	MCM3 Entrez,  Source	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	9611	0.049	0.4934	Yes
38	KIF11	KIF11 Entrez,  Source	kinesin family member 11	9652	0.048	0.5052	Yes
39	NASP	NASP Entrez,  Source	nuclear autoantigenic sperm protein (histone-binding)	9757	0.047	0.5140	Yes
40	FANCI	FANCI Entrez,  Source	Fanconi anemia, complementation group I	9924	0.045	0.5199	Yes
41	MCM7	MCM7 Entrez,  Source	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	9993	0.044	0.5292	Yes
42	HMGB2	HMGB2 Entrez,  Source	high-mobility group box 2	10107	0.042	0.5364	Yes
43	RFC5	RFC5 Entrez,  Source	replication factor C (activator 1) 5, 36.5kDa	10501	0.037	0.5313	No
44	MCM2	MCM2 Entrez,  Source	MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)	10680	0.034	0.5338	No
45	PCNA	PCNA Entrez,  Source	proliferating cell nuclear antigen	10939	0.031	0.5324	No
46	PRC1	PRC1 Entrez,  Source	protein regulator of cytokinesis 1	11666	0.023	0.5105	No
47	FOXM1	FOXM1 Entrez,  Source	forkhead box M1	11822	0.021	0.5103	No
48	METAP2	METAP2 Entrez,  Source	methionyl aminopeptidase 2	11990	0.019	0.5090	No
49	CKS2	CKS2 Entrez,  Source	CDC28 protein kinase regulatory subunit 2	12217	0.016	0.5047	No
50	FEN1	FEN1 Entrez,  Source	flap structure-specific endonuclease 1	12646	0.011	0.4911	No
51	CENPF	CENPF Entrez,  Source	centromere protein F, 350/400ka (mitosin)	13466	0.001	0.4597	No
52	GAR1			13801	-0.003	0.4476	No
53	ZWINT	ZWINT Entrez,  Source	ZW10 interactor	14235	-0.008	0.4331	No
54	GINS2	GINS2 Entrez,  Source	GINS complex subunit 2 (Psf2 homolog)	14397	-0.011	0.4298	No
55	PCCB	PCCB Entrez,  Source	propionyl Coenzyme A carboxylase, beta polypeptide	17337	-0.055	0.3313	No

Fig 2: GNF2_FEN1   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GNF2_FEN1: Random ES distribution   
Gene set null distribution of ES for GNF2_FEN1