Details for gene set GNF2_MCM4[GSEA]

Table: GSEA Results Summary

Dataset	SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos
Phenotype	SMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class	0
GeneSet	GNF2_MCM4
Enrichment Score (ES)	0.53700554
Normalized Enrichment Score (NES)	1.8614823
Nominal p-value	0.0
FDR q-value	0.26802608
FWER p-Value	0.88

Fig 1: Enrichment plot: GNF2_MCM4   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ASF1B	ASF1B Entrez,  Source	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	1459	0.234	0.0134	Yes
2	GINS1	GINS1 Entrez,  Source	GINS complex subunit 1 (Psf1 homolog)	1800	0.195	0.0585	Yes
3	TYMS	TYMS Entrez,  Source	thymidylate synthetase	2505	0.150	0.0762	Yes
4	RAD51AP1	RAD51AP1 Entrez,  Source	RAD51 associated protein 1	2626	0.146	0.1153	Yes
5	NDC80			3031	0.120	0.1355	Yes
6	TTK	TTK Entrez,  Source	TTK protein kinase	3042	0.119	0.1707	Yes
7	BUB1	BUB1 Entrez,  Source	BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)	3261	0.107	0.1944	Yes
8	RFC4	RFC4 Entrez,  Source	replication factor C (activator 1) 4, 37kDa	3299	0.105	0.2244	Yes
9	GMNN	GMNN Entrez,  Source	geminin, DNA replication inhibitor	3370	0.102	0.2521	Yes
10	HELLS	HELLS Entrez,  Source	helicase, lymphoid-specific	3542	0.095	0.2739	Yes
11	SMC4	SMC4 Entrez,  Source	structural maintenance of chromosomes 4	3717	0.088	0.2936	Yes
12	AURKA	AURKA Entrez,  Source	aurora kinase A	3750	0.087	0.3184	Yes
13	MAD2L1	MAD2L1 Entrez,  Source	MAD2 mitotic arrest deficient-like 1 (yeast)	4081	0.083	0.3303	Yes
14	MCM6	MCM6 Entrez,  Source	MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	4276	0.076	0.3455	Yes
15	CCNA2	CCNA2 Entrez,  Source	cyclin A2	7999	0.073	0.2234	Yes
16	UBE2C	UBE2C Entrez,  Source	ubiquitin-conjugating enzyme E2C	8018	0.072	0.2444	Yes
17	MELK	MELK Entrez,  Source	maternal embryonic leucine zipper kinase	8236	0.069	0.2567	Yes
18	CDCA8	CDCA8 Entrez,  Source	cell division cycle associated 8	8511	0.064	0.2652	Yes
19	MCM4	MCM4 Entrez,  Source	MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)	8582	0.062	0.2811	Yes
20	KIF14	KIF14 Entrez,  Source	kinesin family member 14	8695	0.060	0.2948	Yes
21	KIF18B			8919	0.060	0.3040	Yes
22	LMNB1	LMNB1 Entrez,  Source	lamin B1	8951	0.059	0.3204	Yes
23	MCM5	MCM5 Entrez,  Source	MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	9075	0.057	0.3327	Yes
24	RRM1	RRM1 Entrez,  Source	ribonucleotide reductase M1 polypeptide	9137	0.056	0.3470	Yes
25	HMMR	HMMR Entrez,  Source	hyaluronan-mediated motility receptor (RHAMM)	9173	0.055	0.3621	Yes
26	RACGAP1	RACGAP1 Entrez,  Source	Rac GTPase activating protein 1	9253	0.055	0.3753	Yes
27	TOP2A	TOP2A Entrez,  Source	topoisomerase (DNA) II alpha 170kDa	9270	0.054	0.3909	Yes
28	PAICS	PAICS Entrez,  Source	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	9343	0.053	0.4039	Yes
29	CCNB2	CCNB2 Entrez,  Source	cyclin B2	9453	0.051	0.4150	Yes
30	MCM3	MCM3 Entrez,  Source	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	9611	0.049	0.4235	Yes
31	KIF11	KIF11 Entrez,  Source	kinesin family member 11	9652	0.048	0.4364	Yes
32	ASPM	ASPM Entrez,  Source	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	9711	0.047	0.4483	Yes
33	AURKB	AURKB Entrez,  Source	aurora kinase B	9747	0.047	0.4610	Yes
34	NASP	NASP Entrez,  Source	nuclear autoantigenic sperm protein (histone-binding)	9757	0.047	0.4747	Yes
35	FANCI	FANCI Entrez,  Source	Fanconi anemia, complementation group I	9924	0.045	0.4816	Yes
36	MCM7	MCM7 Entrez,  Source	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	9993	0.044	0.4920	Yes
37	POLD1	POLD1 Entrez,  Source	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	10086	0.042	0.5011	Yes
38	TCP1	TCP1 Entrez,  Source	t-complex 1	10156	0.041	0.5108	Yes
39	BUB1B	BUB1B Entrez,  Source	BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)	10437	0.037	0.5112	Yes
40	MCM2	MCM2 Entrez,  Source	MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)	10680	0.034	0.5121	Yes
41	PCNA	PCNA Entrez,  Source	proliferating cell nuclear antigen	10939	0.031	0.5114	Yes
42	CDC20	CDC20 Entrez,  Source	CDC20 cell division cycle 20 homolog (S. cerevisiae)	10950	0.031	0.5202	Yes
43	RFC3	RFC3 Entrez,  Source	replication factor C (activator 1) 3, 38kDa	11033	0.030	0.5260	Yes
44	PA2G4	PA2G4 Entrez,  Source	proliferation-associated 2G4, 38kDa	11100	0.029	0.5322	Yes
45	RRM2	RRM2 Entrez,  Source	ribonucleotide reductase M2 polypeptide	11196	0.028	0.5370	Yes
46	ESPL1	ESPL1 Entrez,  Source	extra spindle poles like 1 (S. cerevisiae)	11672	0.023	0.5254	No
47	FOXM1	FOXM1 Entrez,  Source	forkhead box M1	11822	0.021	0.5259	No
48	CKS2	CKS2 Entrez,  Source	CDC28 protein kinase regulatory subunit 2	12217	0.016	0.5155	No
49	CENPM	CENPM Entrez,  Source	centromere protein M	12220	0.016	0.5202	No
50	FEN1	FEN1 Entrez,  Source	flap structure-specific endonuclease 1	12646	0.011	0.5070	No
51	ZWINT	ZWINT Entrez,  Source	ZW10 interactor	14235	-0.008	0.4480	No
52	GINS2	GINS2 Entrez,  Source	GINS complex subunit 2 (Psf2 homolog)	14397	-0.011	0.4450	No

Fig 2: GNF2_MCM4   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GNF2_MCM4: Random ES distribution   
Gene set null distribution of ES for GNF2_MCM4