Details for gene set GNF2_SMC4L1[GSEA]

Table: GSEA Results Summary

Dataset	SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos
Phenotype	SMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class	0
GeneSet	GNF2_SMC4L1
Enrichment Score (ES)	0.5154438
Normalized Enrichment Score (NES)	1.816987
Nominal p-value	0.0
FDR q-value	0.23841761
FWER p-Value	0.972

Fig 1: Enrichment plot: GNF2_SMC4L1   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	GINS1	GINS1 Entrez,  Source	GINS complex subunit 1 (Psf1 homolog)	1800	0.195	-0.0328	Yes
2	FBXO5	FBXO5 Entrez,  Source	F-box protein 5	1951	0.179	-0.0047	Yes
3	TYMS	TYMS Entrez,  Source	thymidylate synthetase	2505	0.150	0.0024	Yes
4	RAD51AP1	RAD51AP1 Entrez,  Source	RAD51 associated protein 1	2626	0.146	0.0255	Yes
5	POLE2	POLE2 Entrez,  Source	polymerase (DNA directed), epsilon 2 (p59 subunit)	2630	0.146	0.0531	Yes
6	SNRPG	SNRPG Entrez,  Source	small nuclear ribonucleoprotein polypeptide G	2980	0.123	0.0630	Yes
7	NDC80			3031	0.120	0.0837	Yes
8	TTK	TTK Entrez,  Source	TTK protein kinase	3042	0.119	0.1059	Yes
9	DHFR	DHFR Entrez,  Source	dihydrofolate reductase	3124	0.114	0.1245	Yes
10	SHCBP1	SHCBP1 Entrez,  Source	SHC SH2-domain binding protein 1	3202	0.110	0.1424	Yes
11	PLK4	PLK4 Entrez,  Source	polo-like kinase 4 (Drosophila)	3251	0.108	0.1610	Yes
12	PRIM1	PRIM1 Entrez,  Source	primase, polypeptide 1, 49kDa	3268	0.107	0.1806	Yes
13	RFC4	RFC4 Entrez,  Source	replication factor C (activator 1) 4, 37kDa	3299	0.105	0.1994	Yes
14	GMNN	GMNN Entrez,  Source	geminin, DNA replication inhibitor	3370	0.102	0.2160	Yes
15	DKC1	DKC1 Entrez,  Source	dyskeratosis congenita 1, dyskerin	3456	0.098	0.2314	Yes
16	VRK1	VRK1 Entrez,  Source	vaccinia related kinase 1	3639	0.091	0.2417	Yes
17	DTL	DTL Entrez,  Source	denticleless homolog (Drosophila)	3696	0.089	0.2564	Yes
18	SMC4	SMC4 Entrez,  Source	structural maintenance of chromosomes 4	3717	0.088	0.2724	Yes
19	AURKA	AURKA Entrez,  Source	aurora kinase A	3750	0.087	0.2877	Yes
20	USP1	USP1 Entrez,  Source	ubiquitin specific peptidase 1	3988	0.086	0.2948	Yes
21	DUT	DUT Entrez,  Source	dUTP pyrophosphatase	4087	0.082	0.3066	Yes
22	HAT1	HAT1 Entrez,  Source	histone acetyltransferase 1	4293	0.075	0.3130	Yes
23	DTYMK	DTYMK Entrez,  Source	deoxythymidylate kinase (thymidylate kinase)	4302	0.075	0.3270	Yes
24	SRSF1			7992	0.073	0.1980	Yes
25	SLBP	SLBP Entrez,  Source	stem-loop (histone) binding protein	7995	0.073	0.2118	Yes
26	CCNA2	CCNA2 Entrez,  Source	cyclin A2	7999	0.073	0.2256	Yes
27	E2F8	E2F8 Entrez,  Source	E2F transcription factor 8	8004	0.073	0.2393	Yes
28	NUSAP1	NUSAP1 Entrez,  Source	nucleolar and spindle associated protein 1	8179	0.071	0.2459	Yes
29	TMPO	TMPO Entrez,  Source	thymopoietin	8207	0.070	0.2581	Yes
30	DLGAP5			8319	0.068	0.2667	Yes
31	SMC2	SMC2 Entrez,  Source	structural maintenance of chromosomes 2	8352	0.067	0.2782	Yes
32	EXOSC8	EXOSC8 Entrez,  Source	exosome component 8	8408	0.066	0.2886	Yes
33	ZWILCH	ZWILCH Entrez,  Source	Zwilch, kinetochore associated, homolog (Drosophila)	8495	0.064	0.2974	Yes
34	CDCA8	CDCA8 Entrez,  Source	cell division cycle associated 8	8511	0.064	0.3090	Yes
35	CDK1			8548	0.063	0.3195	Yes
36	MCM4	MCM4 Entrez,  Source	MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)	8582	0.062	0.3300	Yes
37	ANP32E	ANP32E Entrez,  Source	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	8593	0.062	0.3414	Yes
38	DNAJC9	DNAJC9 Entrez,  Source	DnaJ (Hsp40) homolog, subfamily C, member 9	8623	0.061	0.3519	Yes
39	KIF18B			8919	0.060	0.3518	Yes
40	MCM5	MCM5 Entrez,  Source	MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	9075	0.057	0.3566	Yes
41	SNRPD1	SNRPD1 Entrez,  Source	small nuclear ribonucleoprotein D1 polypeptide 16kDa	9105	0.056	0.3662	Yes
42	HNRNPAB			9112	0.056	0.3766	Yes
43	RRM1	RRM1 Entrez,  Source	ribonucleotide reductase M1 polypeptide	9137	0.056	0.3862	Yes
44	COPS3	COPS3 Entrez,  Source	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	9146	0.056	0.3965	Yes
45	HMMR	HMMR Entrez,  Source	hyaluronan-mediated motility receptor (RHAMM)	9173	0.055	0.4059	Yes
46	RACGAP1	RACGAP1 Entrez,  Source	Rac GTPase activating protein 1	9253	0.055	0.4132	Yes
47	TOP2A	TOP2A Entrez,  Source	topoisomerase (DNA) II alpha 170kDa	9270	0.054	0.4229	Yes
48	SSRP1	SSRP1 Entrez,  Source	structure specific recognition protein 1	9429	0.052	0.4265	Yes
49	CCNB2	CCNB2 Entrez,  Source	cyclin B2	9453	0.051	0.4353	Yes
50	SUPT16H	SUPT16H Entrez,  Source	suppressor of Ty 16 homolog (S. cerevisiae)	9506	0.050	0.4429	Yes
51	MSH2	MSH2 Entrez,  Source	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	9516	0.050	0.4520	Yes
52	MCM3	MCM3 Entrez,  Source	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	9611	0.049	0.4577	Yes
53	KIF11	KIF11 Entrez,  Source	kinesin family member 11	9652	0.048	0.4653	Yes
54	ASPM	ASPM Entrez,  Source	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	9711	0.047	0.4720	Yes
55	NASP	NASP Entrez,  Source	nuclear autoantigenic sperm protein (histone-binding)	9757	0.047	0.4791	Yes
56	MRPL35	MRPL35 Entrez,  Source	mitochondrial ribosomal protein L35	9864	0.046	0.4837	Yes
57	FANCI	FANCI Entrez,  Source	Fanconi anemia, complementation group I	9924	0.045	0.4899	Yes
58	DEK	DEK Entrez,  Source	DEK oncogene (DNA binding)	9948	0.044	0.4974	Yes
59	MCM7	MCM7 Entrez,  Source	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	9993	0.044	0.5040	Yes
60	HMGB2	HMGB2 Entrez,  Source	high-mobility group box 2	10107	0.042	0.5075	Yes
61	BUB1B	BUB1B Entrez,  Source	BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)	10437	0.037	0.5019	Yes
62	MCM2	MCM2 Entrez,  Source	MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)	10680	0.034	0.4990	Yes
63	SERBP1	SERBP1 Entrez,  Source	SERPINE1 mRNA binding protein 1	10765	0.033	0.5021	Yes
64	ANP32B	ANP32B Entrez,  Source	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B	10836	0.032	0.5055	Yes
65	PCNA	PCNA Entrez,  Source	proliferating cell nuclear antigen	10939	0.031	0.5074	Yes
66	CDC20	CDC20 Entrez,  Source	CDC20 cell division cycle 20 homolog (S. cerevisiae)	10950	0.031	0.5129	Yes
67	RFC3	RFC3 Entrez,  Source	replication factor C (activator 1) 3, 38kDa	11033	0.030	0.5154	Yes
68	EIF2S1	EIF2S1 Entrez,  Source	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	11375	0.026	0.5072	No
69	PRC1	PRC1 Entrez,  Source	protein regulator of cytokinesis 1	11666	0.023	0.5003	No
70	FOXM1	FOXM1 Entrez,  Source	forkhead box M1	11822	0.021	0.4983	No
71	METAP2	METAP2 Entrez,  Source	methionyl aminopeptidase 2	11990	0.019	0.4954	No
72	CKS2	CKS2 Entrez,  Source	CDC28 protein kinase regulatory subunit 2	12217	0.016	0.4897	No
73	NUP153	NUP153 Entrez,  Source	nucleoporin 153kDa	12512	0.012	0.4806	No
74	CKAP2	CKAP2 Entrez,  Source	cytoskeleton associated protein 2	12639	0.011	0.4778	No
75	FEN1	FEN1 Entrez,  Source	flap structure-specific endonuclease 1	12646	0.011	0.4796	No
76	CENPF	CENPF Entrez,  Source	centromere protein F, 350/400ka (mitosin)	13466	0.001	0.4481	No
77	GAR1			13801	-0.003	0.4357	No
78	H2AFX	H2AFX Entrez,  Source	H2A histone family, member X	14049	-0.006	0.4272	No
79	ZWINT	ZWINT Entrez,  Source	ZW10 interactor	14235	-0.008	0.4216	No
80	GINS2	GINS2 Entrez,  Source	GINS complex subunit 2 (Psf2 homolog)	14397	-0.011	0.4174	No
81	CBX3	CBX3 Entrez,  Source	chromobox homolog 3 (HP1 gamma homolog, Drosophila)	16425	-0.038	0.3461	No
82	HNRNPA3			17292	-0.054	0.3229	No
83	PCCB	PCCB Entrez,  Source	propionyl Coenzyme A carboxylase, beta polypeptide	17337	-0.055	0.3316	No

Fig 2: GNF2_SMC4L1   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GNF2_SMC4L1: Random ES distribution   
Gene set null distribution of ES for GNF2_SMC4L1