Details for gene set GO_DEOXYRIBONUCLEASE_ACTIVITY[GSEA]

Table: GSEA Results Summary

Dataset	SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos
Phenotype	SMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class	0
GeneSet	GO_DEOXYRIBONUCLEASE_ACTIVITY
Enrichment Score (ES)	0.5626565
Normalized Enrichment Score (NES)	2.0547664
Nominal p-value	0.0
FDR q-value	0.14603247
FWER p-Value	0.203

Fig 1: Enrichment plot: GO_DEOXYRIBONUCLEASE_ACTIVITY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SETMAR	SETMAR Entrez,  Source	SET domain and mariner transposase fusion gene	28	1.113	0.1621	Yes
2	DNASE1L1	DNASE1L1 Entrez,  Source	deoxyribonuclease I-like 1	125	0.724	0.2644	Yes
3	TREX2	TREX2 Entrez,  Source	three prime repair exonuclease 2	782	0.341	0.2891	Yes
4	RAD1	RAD1 Entrez,  Source	RAD1 homolog (S. pombe)	1045	0.290	0.3215	Yes
5	GEN1			1095	0.280	0.3606	Yes
6	DNASE1L3	DNASE1L3 Entrez,  Source	deoxyribonuclease I-like 3	1158	0.271	0.3980	Yes
7	DCLRE1B	DCLRE1B Entrez,  Source	DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)	1421	0.239	0.4229	Yes
8	MBD4	MBD4 Entrez,  Source	methyl-CpG binding domain protein 4	1590	0.217	0.4482	Yes
9	DNASE1L2	DNASE1L2 Entrez,  Source	deoxyribonuclease I-like 2	1680	0.207	0.4751	Yes
10	RAD50	RAD50 Entrez,  Source	RAD50 homolog (S. cerevisiae)	2833	0.133	0.4500	Yes
11	EME1	EME1 Entrez,  Source	essential meiotic endonuclease 1 homolog 1 (S. pombe)	2841	0.132	0.4691	Yes
12	DFFB	DFFB Entrez,  Source	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	2890	0.129	0.4862	Yes
13	XRCC2	XRCC2 Entrez,  Source	X-ray repair complementing defective repair in Chinese hamster cells 2	3138	0.114	0.4933	Yes
14	DEM1			3340	0.103	0.5007	Yes
15	SMUG1	SMUG1 Entrez,  Source	single-strand-selective monofunctional uracil-DNA glycosylase 1	3552	0.095	0.5064	Yes
16	RPS3	RPS3 Entrez,  Source	ribosomal protein S3	3602	0.093	0.5181	Yes
17	DCLRE1A	DCLRE1A Entrez,  Source	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)	3603	0.093	0.5317	Yes
18	OGG1	OGG1 Entrez,  Source	8-oxoguanine DNA glycosylase	3661	0.091	0.5428	Yes
19	EXO1	EXO1 Entrez,  Source	exonuclease 1	4079	0.083	0.5387	Yes
20	DNASE2B	DNASE2B Entrez,  Source	deoxyribonuclease II beta	4171	0.079	0.5468	Yes
21	DMC1	DMC1 Entrez,  Source	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	4301	0.075	0.5529	Yes
22	RAD51	RAD51 Entrez,  Source	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	4332	0.074	0.5627	Yes
23	RBBP8	RBBP8 Entrez,  Source	retinoblastoma binding protein 8	8178	0.071	0.4242	No
24	TREX1	TREX1 Entrez,  Source	three prime repair exonuclease 1	9102	0.056	0.3968	No
25	ALKBH1	ALKBH1 Entrez,  Source	alkB, alkylation repair homolog 1 (E. coli)	9690	0.048	0.3810	No
26	APEX1	APEX1 Entrez,  Source	APEX nuclease (multifunctional DNA repair enzyme) 1	9914	0.045	0.3790	No
27	APEX2	APEX2 Entrez,  Source	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	9990	0.044	0.3825	No
28	FAN1			10019	0.043	0.3877	No
29	POLD1	POLD1 Entrez,  Source	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	10086	0.042	0.3914	No
30	ZRANB3	ZRANB3 Entrez,  Source	zinc finger, RAN-binding domain containing 3	10264	0.040	0.3904	No
31	TATDN2	TATDN2 Entrez,  Source	TatD DNase domain containing 2	10307	0.039	0.3945	No
32	NEIL3	NEIL3 Entrez,  Source	nei endonuclease VIII-like 3 (E. coli)	10382	0.038	0.3973	No
33	DNA2			10747	0.033	0.3881	No
34	NME1	NME1 Entrez,  Source	non-metastatic cells 1, protein (NM23A) expressed in	10797	0.033	0.3910	No
35	MRE11A	MRE11A Entrez,  Source	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	11214	0.028	0.3790	No
36	DCLRE1C	DCLRE1C Entrez,  Source	DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)	11483	0.025	0.3723	No
37	TATDN1	TATDN1 Entrez,  Source	TatD DNase domain containing 1	11639	0.023	0.3697	No
38	ERCC1	ERCC1 Entrez,  Source	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	11774	0.022	0.3677	No
39	HMGA2	HMGA2 Entrez,  Source	high mobility group AT-hook 2	11790	0.021	0.3702	No
40	EXD2			12616	0.011	0.3399	No
41	FEN1	FEN1 Entrez,  Source	flap structure-specific endonuclease 1	12646	0.011	0.3404	No
42	MUS81	MUS81 Entrez,  Source	MUS81 endonuclease homolog (S. cerevisiae)	13797	-0.003	0.2964	No
43	SLX1B			13841	-0.003	0.2952	No
44	SLX4			13997	-0.005	0.2900	No
45	DNASE1	DNASE1 Entrez,  Source	deoxyribonuclease I	14678	-0.015	0.2658	No
46	NTHL1	NTHL1 Entrez,  Source	nth endonuclease III-like 1 (E. coli)	14759	-0.016	0.2650	No
47	ERCC4	ERCC4 Entrez,  Source	excision repair cross-complementing rodent repair deficiency, complementation group 4	14817	-0.017	0.2653	No
48	RAD51C	RAD51C Entrez,  Source	RAD51 homolog C (S. cerevisiae)	15118	-0.021	0.2568	No
49	DICER1	DICER1 Entrez,  Source	Dicer1, Dcr-1 homolog (Drosophila)	16988	-0.048	0.1916	No
50	ERCC5	ERCC5 Entrez,  Source	me))	17348	-0.055	0.1858	No
51	POLB	POLB Entrez,  Source	polymerase (DNA directed), beta	17433	-0.057	0.1909	No
52	ENDOG	ENDOG Entrez,  Source	endonuclease G	17494	-0.059	0.1972	No
53	APLF			18013	-0.071	0.1876	No
54	XRCC3	XRCC3 Entrez,  Source	X-ray repair complementing defective repair in Chinese hamster cells 3	18052	-0.072	0.1967	No
55	APTX	APTX Entrez,  Source	aprataxin	18735	-0.092	0.1837	No
56	HMGA1	HMGA1 Entrez,  Source	high mobility group AT-hook 1	19069	-0.103	0.1859	No
57	ISG20	ISG20 Entrez,  Source	interferon stimulated exonuclease gene 20kDa	19862	-0.134	0.1750	No
58	NEIL1	NEIL1 Entrez,  Source	nei endonuclease VIII-like 1 (E. coli)	20907	-0.183	0.1614	No
59	NEIL2	NEIL2 Entrez,  Source	nei like 2 (E. coli)	21412	-0.216	0.1736	No

Fig 2: GO_DEOXYRIBONUCLEASE_ACTIVITY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GO_DEOXYRIBONUCLEASE_ACTIVITY: Random ES distribution   
Gene set null distribution of ES for GO_DEOXYRIBONUCLEASE_ACTIVITY