Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 0 |
| GeneSet | GO_DNA_CATABOLIC_PROCESS |
| Enrichment Score (ES) | 0.6415734 |
| Normalized Enrichment Score (NES) | 1.9798049 |
| Nominal p-value | 0.007874016 |
| FDR q-value | 0.15642527 |
| FWER p-Value | 0.466 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SETMAR | SETMAR Entrez, Source | SET domain and mariner transposase fusion gene | 28 | 1.113 | 0.2364 | Yes |
| 2 | DNASE1L1 | DNASE1L1 Entrez, Source | deoxyribonuclease I-like 1 | 125 | 0.724 | 0.3871 | Yes |
| 3 | SPO11 | SPO11 Entrez, Source | SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) | 132 | 0.712 | 0.5389 | Yes |
| 4 | DNASE1L3 | DNASE1L3 Entrez, Source | deoxyribonuclease I-like 3 | 1158 | 0.271 | 0.5572 | Yes |
| 5 | DNASE1L2 | DNASE1L2 Entrez, Source | deoxyribonuclease I-like 2 | 1680 | 0.207 | 0.5813 | Yes |
| 6 | CECR2 | CECR2 Entrez, Source | cat eye syndrome chromosome region, candidate 2 | 1838 | 0.190 | 0.6158 | Yes |
| 7 | H1F0 | H1F0 Entrez, Source | H1 histone family, member 0 | 2096 | 0.167 | 0.6416 | Yes |
| 8 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 2890 | 0.129 | 0.6384 | No |
| 9 | DNASE2B | DNASE2B Entrez, Source | deoxyribonuclease II beta | 4171 | 0.079 | 0.6059 | No |
| 10 | KPNB1 | KPNB1 Entrez, Source | karyopherin (importin) beta 1 | 9818 | 0.046 | 0.3975 | No |
| 11 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 9857 | 0.046 | 0.4057 | No |
| 12 | HMGB2 | HMGB2 Entrez, Source | high-mobility group box 2 | 10107 | 0.042 | 0.4051 | No |
| 13 | TATDN2 | TATDN2 Entrez, Source | TatD DNase domain containing 2 | 10307 | 0.039 | 0.4058 | No |
| 14 | XRN2 | XRN2 Entrez, Source | 5'-3' exoribonuclease 2 | 10589 | 0.035 | 0.4025 | No |
| 15 | TATDN1 | TATDN1 Entrez, Source | TatD DNase domain containing 1 | 11639 | 0.023 | 0.3669 | No |
| 16 | KPNA1 | KPNA1 Entrez, Source | karyopherin alpha 1 (importin alpha 5) | 12179 | 0.017 | 0.3496 | No |
| 17 | MUS81 | MUS81 Entrez, Source | MUS81 endonuclease homolog (S. cerevisiae) | 13797 | -0.003 | 0.2877 | No |
| 18 | AIFM1 | 14224 | -0.008 | 0.2730 | No | ||
| 19 | DNASE1 | DNASE1 Entrez, Source | deoxyribonuclease I | 14678 | -0.015 | 0.2586 | No |
| 20 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 15266 | -0.024 | 0.2409 | No |
| 21 | FBXO18 | FBXO18 Entrez, Source | F-box protein, helicase, 18 | 16415 | -0.038 | 0.2046 | No |
| 22 | DICER1 | DICER1 Entrez, Source | Dicer1, Dcr-1 homolog (Drosophila) | 16988 | -0.048 | 0.1928 | No |
| 23 | ENDOG | ENDOG Entrez, Source | endonuclease G | 17494 | -0.059 | 0.1859 | No |
| 24 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 19862 | -0.134 | 0.1230 | No |
| 25 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 20261 | -0.151 | 0.1398 | No |
| 26 | FOXL2 | FOXL2 Entrez, Source | forkhead box L2 | 22996 | -0.366 | 0.1122 | No |
