Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 0 |
| GeneSet | GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT |
| Enrichment Score (ES) | 0.68113995 |
| Normalized Enrichment Score (NES) | 1.8815709 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.2452338 |
| FWER p-Value | 0.825 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SAG | SAG Entrez, Source | S-antigen; retina and pineal gland (arrestin) | 148 | 0.689 | 0.1466 | Yes |
| 2 | RHO | RHO Entrez, Source | rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant) | 244 | 0.574 | 0.2699 | Yes |
| 3 | PDE6C | PDE6C Entrez, Source | phosphodiesterase 6C, cGMP-specific, cone, alpha prime | 366 | 0.490 | 0.3737 | Yes |
| 4 | RP1 | RP1 Entrez, Source | retinitis pigmentosa 1 (autosomal dominant) | 378 | 0.484 | 0.4802 | Yes |
| 5 | CNGB1 | CNGB1 Entrez, Source | cyclic nucleotide gated channel beta 1 | 814 | 0.336 | 0.5378 | Yes |
| 6 | GRK1 | GRK1 Entrez, Source | G protein-coupled receptor kinase 1 | 924 | 0.314 | 0.6030 | Yes |
| 7 | GNAT1 | GNAT1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 | 1922 | 0.181 | 0.6046 | Yes |
| 8 | CNGA1 | CNGA1 Entrez, Source | cyclic nucleotide gated channel alpha 1 | 1955 | 0.179 | 0.6429 | Yes |
| 9 | OPN4 | OPN4 Entrez, Source | opsin 4 (melanopsin) | 1975 | 0.176 | 0.6811 | Yes |
| 10 | GNGT1 | GNGT1 Entrez, Source | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 4626 | 0.074 | 0.5952 | No |
| 11 | RDH11 | RDH11 Entrez, Source | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 8461 | 0.065 | 0.4614 | No |
| 12 | RS1 | RS1 Entrez, Source | retinoschisis (X-linked, juvenile) 1 | 10144 | 0.042 | 0.4056 | No |
| 13 | GNB1 | GNB1 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 11440 | 0.025 | 0.3612 | No |
| 14 | GNAQ | GNAQ Entrez, Source | guanine nucleotide binding protein (G protein), q polypeptide | 11818 | 0.021 | 0.3512 | No |
| 15 | GNA11 | GNA11 Entrez, Source | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 15767 | -0.030 | 0.2054 | No |
| 16 | ABCA4 | ABCA4 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 4 | 16390 | -0.037 | 0.1896 | No |
| 17 | PDE6A | PDE6A Entrez, Source | phosphodiesterase 6A, cGMP-specific, rod, alpha | 18431 | -0.083 | 0.1291 | No |
| 18 | PDE6B | PDE6B Entrez, Source | phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant) | 20798 | -0.177 | 0.0767 | No |
| 19 | AIPL1 | AIPL1 Entrez, Source | aryl hydrocarbon receptor interacting protein-like 1 | 21292 | -0.209 | 0.1039 | No |
| 20 | PDE6G | PDE6G Entrez, Source | phosphodiesterase 6G, cGMP-specific, rod, gamma | 22743 | -0.335 | 0.1219 | No |
