DatasetSMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls
#del_versus_fl.SMCHD1_KO.cls
#del_versus_fl_repos
PhenotypeSMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class1
GeneSetGSE42724_NAIVE_BCELL_VS_PLASMABLAST_UP
Enrichment Score (ES)-0.7489225
Normalized Enrichment Score (NES)-1.8175259
Nominal p-value0.0
FDR q-value6.322941E-4
FWER p-Value0.025
Table: GSEA Results Summary



Fig 1: Enrichment plot: GSE42724_NAIVE_BCELL_VS_PLASMABLAST_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SIGLEC1SIGLEC1
Entrez,  Source
sialic acid binding Ig-like lectin 1, sialoadhesin1140.7500.0046No
2LAG3LAG3
Entrez,  Source
lymphocyte-activation gene 31970.6200.0088No
3GBP5GBP5
Entrez,  Source
guanylate binding protein 52020.6140.0160No
4TRIM21TRIM21
Entrez,  Source
tripartite motif-containing 216180.3890.0045No
5IFITM1IFITM1
Entrez,  Source
interferon induced transmembrane protein 1 (9-27)9950.299-0.0065No
6OTOFOTOF
Entrez,  Source
otoferlin15120.230-0.0238No
7MVPMVP
Entrez,  Source
major vault protein16930.205-0.0283No
8BRIP1BRIP1
Entrez,  Source
BRCA1 interacting protein C-terminal helicase 120540.171-0.0402No
9CXCL11CXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1124360.157-0.0532No
10CFBCFB
Entrez,  Source
complement factor B28940.128-0.0694No
11STARD4STARD4
Entrez,  Source
START domain containing 4, sterol regulated31690.112-0.0787No
12STAT2STAT2
Entrez,  Source
signal transducer and activator of transcription 2, 113kDa34410.099-0.0880No
13SPATS2L36820.090-0.0963No
14HSH2DHSH2D
Entrez,  Source
hematopoietic SH2 domain containing36950.089-0.0957No
15GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)37430.087-0.0965No
16ZBP1ZBP1
Entrez,  Source
Z-DNA binding protein 140160.085-0.1060No
17MASTLMASTL
Entrez,  Source
microtubule associated serine/threonine kinase-like42100.078-0.1126No
18TIMD4TIMD4
Entrez,  Source
T-cell immunoglobulin and mucin domain containing 446140.074-0.1273No
19HESX1HESX1
Entrez,  Source
homeobox, ES cell expressed 151220.074-0.1462No
20PRR9PRR9
Entrez,  Source
proline rich 963550.074-0.1931No
21NT5C3NT5C3
Entrez,  Source
5'-nucleotidase, cytosolic III79850.074-0.2556No
22E2F8E2F8
Entrez,  Source
E2F transcription factor 880040.073-0.2554No
23CLEC4DCLEC4D
Entrez,  Source
C-type lectin domain family 4, member D81260.072-0.2592No
24RTN1RTN1
Entrez,  Source
reticulon 189610.059-0.2909No
25MCM5MCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)90750.057-0.2946No
26SP110SP110
Entrez,  Source
SP110 nuclear body protein90800.057-0.2941No
27TREX1TREX1
Entrez,  Source
three prime repair exonuclease 191020.056-0.2942No
28OAS3OAS3
Entrez,  Source
2'-5'-oligoadenylate synthetase 3, 100kDa92420.055-0.2990No
29PPM1KPPM1K
Entrez,  Source
protein phosphatase 1K (PP2C domain containing)94770.051-0.3075No
30TDRD7TDRD7
Entrez,  Source
tudor domain containing 7101880.041-0.3346No
31TNFSF10TNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 10102440.040-0.3362No
32MRPL40MRPL40
Entrez,  Source
mitochondrial ribosomal protein L40104100.038-0.3422No
33SSBSSB
Entrez,  Source
Sjogren syndrome antigen B (autoantigen La)105030.037-0.3453No
34UBAP1UBAP1
Entrez,  Source
ubiquitin associated protein 1105520.036-0.3468No
35GBP1GBP1
Entrez,  Source
guanylate binding protein 1, interferon-inducible, 67kDa106310.035-0.3494No
36HUS1HUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)109210.031-0.3602No
37RAB8ARAB8A
Entrez,  Source
RAB8A, member RAS oncogene family113170.027-0.3753No
38CNPCNP
Entrez,  Source
2',3'-cyclic nucleotide 3' phosphodiesterase113350.027-0.3756No
39LAP3LAP3
Entrez,  Source
leucine aminopeptidase 3114340.025-0.3791No
40ST7ST7
Entrez,  Source
suppression of tumorigenicity 7117680.022-0.3918No
41SRGAP2SRGAP2
Entrez,  Source
SLIT-ROBO Rho GTPase activating protein 2118800.020-0.3959No
42PATL1121380.017-0.4056No
43NUB1NUB1
Entrez,  Source
negative regulator of ubiquitin-like proteins 1122970.015-0.4116No
44PNPT1PNPT1
Entrez,  Source
polyribonucleotide nucleotidyltransferase 1123290.015-0.4126No
45FAM46AFAM46A
Entrez,  Source
family with sequence similarity 46, member A124290.013-0.4163No
46RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 1124850.013-0.4183No
47MAD2L1BPMAD2L1BP
Entrez,  Source
MAD2L1 binding protein133260.003-0.4509No
48PHACTR4PHACTR4
Entrez,  Source
phosphatase and actin regulator 413746-0.003-0.4672No
49COQ10BCOQ10B
Entrez,  Source
coenzyme Q10 homolog B (S. cerevisiae)13783-0.003-0.4685No
50NEXNNEXN
Entrez,  Source
nexilin (F actin binding protein)14171-0.007-0.4835No
51FBXO6FBXO6
Entrez,  Source
F-box protein 614359-0.010-0.4906No
52NADKNADK
Entrez,  Source
NAD kinase14442-0.011-0.4937No
53TMEM140TMEM140
Entrez,  Source
transmembrane protein 14014623-0.014-0.5005No
54SCARB2SCARB2
Entrez,  Source
scavenger receptor class B, member 214644-0.014-0.5011No
55KIRRELKIRREL
Entrez,  Source
kin of IRRE like (Drosophila)14650-0.014-0.5011No
56XPO6XPO6
Entrez,  Source
exportin 614770-0.016-0.5056No
57TYMP14791-0.016-0.5061No
58GCLMGCLM
Entrez,  Source
glutamate-cysteine ligase, modifier subunit14830-0.017-0.5074No
59PPPDE214941-0.019-0.5115No
60NKIRAS2NKIRAS2
Entrez,  Source
NFKB inhibitor interacting Ras-like 214964-0.019-0.5121No
61PSMA4PSMA4
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 415175-0.022-0.5200No
62EPDR1EPDR1
Entrez,  Source
ependymin related protein 1 (zebrafish)15375-0.024-0.5274No
63FRMD3FRMD3
Entrez,  Source
FERM domain containing 315496-0.026-0.5318No
64BATF2BATF2
Entrez,  Source
basic leucine zipper transcription factor, ATF-like 216492-0.039-0.5700No
65DDIT3DDIT3
Entrez,  Source
DNA-damage-inducible transcript 316525-0.039-0.5708No
66FTSJD216599-0.041-0.5731No
67SQSTM1SQSTM1
Entrez,  Source
sequestosome 116666-0.042-0.5752No
68CD2APCD2AP
Entrez,  Source
CD2-associated protein16696-0.043-0.5758No
69FBXO32FBXO32
Entrez,  Source
F-box protein 3216806-0.045-0.5795No
70CLEC1ACLEC1A
Entrez,  Source
C-type lectin domain family 1, member A16965-0.048-0.5850No
71CSRNP116989-0.048-0.5854No
72PSME1PSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)17203-0.052-0.5930No
73NAPANAPA
Entrez,  Source
N-ethylmaleimide-sensitive factor attachment protein, alpha17380-0.056-0.5992No
74NMINMI
Entrez,  Source
N-myc (and STAT) interactor17473-0.058-0.6020No
75MOV10MOV10
Entrez,  Source
Mov10, Moloney leukemia virus 10, homolog (mouse)18149-0.075-0.6274No
76UBA718403-0.082-0.6362No
77PCGF5PCGF5
Entrez,  Source
polycomb group ring finger 518570-0.087-0.6416No
78UBE2L6UBE2L6
Entrez,  Source
ubiquitin-conjugating enzyme E2L 618633-0.089-0.6430No
79TRAFD1TRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 119019-0.101-0.6567No
80SLC25A28SLC25A28
Entrez,  Source
solute carrier family 25, member 2819038-0.102-0.6562No
81PLSCR1PLSCR1
Entrez,  Source
phospholipid scramblase 119108-0.104-0.6576No
82DDHD1DDHD1
Entrez,  Source
DDHD domain containing 119301-0.111-0.6638No
83SHISA519322-0.112-0.6632No
84SP140SP140
Entrez,  Source
SP140 nuclear body protein19352-0.114-0.6630No
85ITGB7ITGB7
Entrez,  Source
integrin, beta 719540-0.121-0.6688No
86NRIP1NRIP1
Entrez,  Source
nuclear receptor interacting protein 119549-0.121-0.6676No
87STOMSTOM
Entrez,  Source
stomatin19559-0.122-0.6665No
88DNAJB4DNAJB4
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 419768-0.131-0.6731No
89APOL6APOL6
Entrez,  Source
apolipoprotein L, 619838-0.133-0.6741No
90ISG20ISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa19862-0.134-0.6734No
91ZNFX1ZNFX1
Entrez,  Source
zinc finger, NFX1-type containing 119866-0.134-0.6719No
92PMLPML
Entrez,  Source
promyelocytic leukemia20690-0.171-0.7018No
93MYD88MYD88
Entrez,  Source
myeloid differentiation primary response gene (88)21196-0.201-0.7191No
94B3GNT2B3GNT2
Entrez,  Source
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 221219-0.203-0.7175No
95IL15RAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha21510-0.224-0.7261No
96EPHB2EPHB2
Entrez,  Source
EPH receptor B221579-0.230-0.7260No
97HERC6HERC6
Entrez,  Source
hect domain and RLD 621820-0.248-0.7323No
98BTG3BTG3
Entrez,  Source
BTG family, member 321833-0.249-0.7298No
99DNAJB9DNAJB9
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 921835-0.250-0.7268No
100EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 221911-0.256-0.7267No
101FCHSD1FCHSD1
Entrez,  Source
FCH and double SH3 domains 122223-0.281-0.7354No
102ITIH4ITIH4
Entrez,  Source
inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)22352-0.293-0.7368No
103IRF922485-0.307-0.7383No
104GMPRGMPR
Entrez,  Source
guanosine monophosphate reductase22516-0.310-0.7357No
105LY6ELY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E22607-0.320-0.7354No
106IRF1IRF1
Entrez,  Source
interferon regulatory factor 122778-0.338-0.7379No
107BST2BST2
Entrez,  Source
bone marrow stromal cell antigen 222902-0.355-0.7385No
108CLDN1CLDN1
Entrez,  Source
claudin 123172-0.387-0.7443Yes
109STAT1STAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa23259-0.399-0.7428Yes
110CMPK223278-0.403-0.7387Yes
111AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase23294-0.405-0.7344Yes
112TRIM5TRIM5
Entrez,  Source
tripartite motif-containing 523487-0.433-0.7367Yes
113FUT4FUT4
Entrez,  Source
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)23500-0.434-0.7320Yes
114EPSTI1EPSTI1
Entrez,  Source
epithelial stromal interaction 1 (breast)23538-0.439-0.7282Yes
115PARP12PARP12
Entrez,  Source
poly (ADP-ribose) polymerase family, member 1223548-0.441-0.7232Yes
116KCTD14KCTD14
Entrez,  Source
potassium channel tetramerisation domain containing 1423568-0.444-0.7186Yes
117CXCL10CXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1023939-0.510-0.7269Yes
118ACSM523961-0.514-0.7215Yes
119DDX58DDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5824122-0.545-0.7212Yes
120PARP9PARP9
Entrez,  Source
poly (ADP-ribose) polymerase family, member 924171-0.559-0.7164Yes
121TAP1TAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)24212-0.568-0.7111Yes
122TAPBPLTAPBPL
Entrez,  Source
TAP binding protein-like24395-0.615-0.7108Yes
123RTP1RTP1
Entrez,  Source
receptor transporter protein 124434-0.627-0.7048Yes
124MTL5MTL5
Entrez,  Source
metallothionein-like 5, testis-specific (tesmin)24436-0.627-0.6973Yes
125DHX5824511-0.647-0.6924Yes
126DTX3LDTX3L
Entrez,  Source
deltex 3-like (Drosophila)24573-0.670-0.6868Yes
127IFIT2IFIT2
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 224672-0.695-0.6822Yes
128CHRM1CHRM1
Entrez,  Source
cholinergic receptor, muscarinic 124828-0.746-0.6793Yes
129CD38CD38
Entrez,  Source
CD38 molecule24844-0.751-0.6709Yes
130TUFT1TUFT1
Entrez,  Source
tuftelin 124867-0.763-0.6626Yes
131SLC22A4SLC22A4
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 424933-0.788-0.6557Yes
132PDGFRLPDGFRL
Entrez,  Source
platelet-derived growth factor receptor-like25017-0.831-0.6489Yes
133TRIM25TRIM25
Entrez,  Source
tripartite motif-containing 2525023-0.834-0.6391Yes
134TAP2TAP2
Entrez,  Source
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)25145-0.894-0.6331Yes
135MX2MX2
Entrez,  Source
myxovirus (influenza virus) resistance 2 (mouse)25230-0.948-0.6250Yes
136VSIG10L25240-0.957-0.6139Yes
137SERPING1SERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)25269-0.979-0.6032Yes
138DACT2DACT2
Entrez,  Source
dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)25275-0.983-0.5916Yes
139TLR3TLR3
Entrez,  Source
toll-like receptor 325298-1.003-0.5805Yes
140HIST1H2ACHIST1H2AC
Entrez,  Source
histone cluster 1, H2ac25301-1.006-0.5685Yes
141MX1MX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)25437-1.129-0.5602Yes
142RBM11RBM11
Entrez,  Source
RNA binding motif protein 1125483-1.182-0.5478Yes
143OAS2OAS2
Entrez,  Source
2'-5'-oligoadenylate synthetase 2, 69/71kDa25558-1.284-0.5353Yes
144IFI35IFI35
Entrez,  Source
interferon-induced protein 3525621-1.385-0.5211Yes
145PARP14PARP14
Entrez,  Source
poly (ADP-ribose) polymerase family, member 1425624-1.394-0.5044Yes
146GBP4GBP4
Entrez,  Source
guanylate binding protein 425655-1.448-0.4882Yes
147AIM2AIM2
Entrez,  Source
absent in melanoma 225658-1.467-0.4707Yes
148PARP10PARP10
Entrez,  Source
poly (ADP-ribose) polymerase family, member 1025663-1.472-0.4532Yes
149ISG15ISG15
Entrez,  Source
ISG15 ubiquitin-like modifier25699-1.594-0.4355Yes
150DDX6025710-1.643-0.4162Yes
151CASP12CASP12
Entrez,  Source
caspase 1225754-1.792-0.3963Yes
152LGALS3BPLGALS3BP
Entrez,  Source
lectin, galactoside-binding, soluble, 3 binding protein25761-1.839-0.3745Yes
153PSMB9PSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)25769-1.855-0.3525Yes
154IRF7IRF7
Entrez,  Source
interferon regulatory factor 725794-2.009-0.3294Yes
155RSAD2RSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 225795-2.013-0.3053Yes
156IFIH1IFIH1
Entrez,  Source
interferon induced with helicase C domain 125804-2.052-0.2810Yes
157XAF125822-2.156-0.2558Yes
158USP18USP18
Entrez,  Source
ubiquitin specific peptidase 1825830-2.231-0.2293Yes
159IFI44IFI44
Entrez,  Source
interferon-induced protein 4425831-2.278-0.2020Yes
160RTP4RTP4
Entrez,  Source
receptor transporter protein 425833-2.300-0.1744Yes
161CASP1CASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)25838-2.365-0.1462Yes
162IFIT3IFIT3
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 325844-2.414-0.1175Yes
163NLRC525867-2.711-0.0858Yes
164SAMD9LSAMD9L
Entrez,  Source
sterile alpha motif domain containing 9-like25888-3.178-0.0485Yes
165IFIT1IFIT1
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 125894-4.0730.0002Yes
Table: GSEA details [plain text format]



Fig 2: GSE42724_NAIVE_BCELL_VS_PLASMABLAST_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GSE42724_NAIVE_BCELL_VS_PLASMABLAST_UP: Random ES distribution   
Gene set null distribution of ES for GSE42724_NAIVE_BCELL_VS_PLASMABLAST_UP