DatasetSMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls
#del_versus_fl.SMCHD1_KO.cls
#del_versus_fl_repos
PhenotypeSMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class0
GeneSetHALLMARK_E2F_TARGETS
Enrichment Score (ES)0.45815733
Normalized Enrichment Score (NES)1.9776442
Nominal p-value0.0
FDR q-value0.1352297
FWER p-Value0.476
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_E2F_TARGETS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1RAD1RAD1
Entrez,  Source
RAD1 homolog (S. pombe)10450.290-0.0155Yes
2DCLRE1BDCLRE1B
Entrez,  Source
DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)14210.239-0.0093Yes
3ASF1BASF1B
Entrez,  Source
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)14590.2340.0096Yes
4GINS3GINS3
Entrez,  Source
GINS complex subunit 3 (Psf3 homolog)15440.2240.0258Yes
5GINS1GINS1
Entrez,  Source
GINS complex subunit 1 (Psf1 homolog)18000.1950.0328Yes
6RPA3RPA3
Entrez,  Source
replication protein A3, 14kDa18860.1840.0454Yes
7RAD51AP1RAD51AP1
Entrez,  Source
RAD51 associated protein 126260.1460.0294Yes
8TRIP13TRIP13
Entrez,  Source
thyroid hormone receptor interactor 1327020.1410.0388Yes
9DSCC127540.1370.0487Yes
10RAD50RAD50
Entrez,  Source
RAD50 homolog (S. cerevisiae)28330.1330.0571Yes
11CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)29280.1260.0645Yes
12CKS1BCKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B29420.1250.0749Yes
13MYCMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)30120.1210.0827Yes
14MMS22L31180.1150.0885Yes
15TIPINTIPIN
Entrez,  Source
TIMELESS interacting protein31390.1140.0976Yes
16BARD1BARD1
Entrez,  Source
BRCA1 associated RING domain 131460.1130.1072Yes
17SPC2431950.1110.1150Yes
18NUP107NUP107
Entrez,  Source
nucleoporin 107kDa32470.1080.1224Yes
19PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)32510.1080.1316Yes
20WDR90WDR90
Entrez,  Source
WD repeat domain 9033390.1030.1372Yes
21TIMELESSTIMELESS
Entrez,  Source
timeless homolog (Drosophila)33610.1020.1453Yes
22LBRLBR
Entrez,  Source
lamin B receptor34970.0980.1485Yes
23HELLSHELLS
Entrez,  Source
helicase, lymphoid-specific35420.0950.1550Yes
24MXD3MXD3
Entrez,  Source
MAX dimerization protein 335710.0940.1621Yes
25BIRC5BIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)36910.0900.1653Yes
26SMC4SMC4
Entrez,  Source
structural maintenance of chromosomes 437170.0880.1720Yes
27AURKAAURKA
Entrez,  Source
aurora kinase A37500.0870.1783Yes
28STAG1STAG1
Entrez,  Source
stromal antigen 137510.0870.1859Yes
29USP1USP1
Entrez,  Source
ubiquitin specific peptidase 139880.0860.1841Yes
30MTHFD2MTHFD2
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase40270.0840.1900Yes
31PRIM240660.0830.1957Yes
32MAD2L1MAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)40810.0830.2024Yes
33DUTDUT
Entrez,  Source
dUTP pyrophosphatase40870.0820.2093Yes
34ORC241430.0800.2142Yes
35ING3ING3
Entrez,  Source
inhibitor of growth family, member 341790.0790.2197Yes
36ASF1AASF1A
Entrez,  Source
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)42330.0770.2243Yes
37SMC6SMC6
Entrez,  Source
structural maintenance of chromosomes 642600.0770.2300Yes
38KIF2CKIF2C
Entrez,  Source
kinesin family member 2C42670.0760.2364Yes
39NBNNBN
Entrez,  Source
nibrin42680.0760.2430Yes
40MCM6MCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)42760.0760.2493Yes
41DCTPP143350.0740.2535Yes
42SRSF179920.0730.1177Yes
43SLBPSLBP
Entrez,  Source
stem-loop (histone) binding protein79950.0730.1240Yes
44E2F8E2F8
Entrez,  Source
E2F transcription factor 880040.0730.1300Yes
45CDC25ACDC25A
Entrez,  Source
cell division cycle 25A80400.0720.1349Yes
46LYARLYAR
Entrez,  Source
-81340.0720.1375Yes
47GINS4GINS4
Entrez,  Source
GINS complex subunit 4 (Sld5 homolog)81440.0710.1433Yes
48TMPOTMPO
Entrez,  Source
thymopoietin82070.0700.1470Yes
49NUDT21NUDT21
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 2182350.0690.1520Yes
50MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase82360.0690.1580Yes
51RQCD1RQCD1
Entrez,  Source
RCD1 required for cell differentiation1 homolog (S. pombe)82640.0690.1629Yes
52PSMC3IPPSMC3IP
Entrez,  Source
PSMC3 interacting protein82900.0680.1679Yes
53POLE4POLE4
Entrez,  Source
polymerase (DNA-directed), epsilon 4 (p12 subunit)83000.0680.1735Yes
54DLGAP583190.0680.1787Yes
55EXOSC8EXOSC8
Entrez,  Source
exosome component 884080.0660.1810Yes
56NAA3884770.0650.1840Yes
57CDCA8CDCA8
Entrez,  Source
cell division cycle associated 885110.0640.1882Yes
58BRCA1BRCA1
Entrez,  Source
breast cancer 1, early onset85410.0630.1926Yes
59CDK185480.0630.1978Yes
60KIF22KIF22
Entrez,  Source
kinesin family member 2285530.0630.2031Yes
61SPC2585590.0630.2084Yes
62MCM4MCM4
Entrez,  Source
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)85820.0620.2129Yes
63ANP32EANP32E
Entrez,  Source
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E85930.0620.2179Yes
64EZH2EZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)86260.0610.2220Yes
65RPA2RPA2
Entrez,  Source
replication protein A2, 32kDa86460.0610.2266Yes
66RNASEH2ARNASEH2A
Entrez,  Source
ribonuclease H2, subunit A86480.0610.2318Yes
67PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)86880.0600.2356Yes
68KIF18B89190.0600.2318Yes
69LIG1LIG1
Entrez,  Source
ligase I, DNA, ATP-dependent89280.0590.2366Yes
70CSE1LCSE1L
Entrez,  Source
CSE1 chromosome segregation 1-like (yeast)89480.0590.2410Yes
71LMNB1LMNB1
Entrez,  Source
lamin B189510.0590.2460Yes
72PNNPNN
Entrez,  Source
pinin, desmosome associated protein89600.0590.2508Yes
73SMC3SMC3
Entrez,  Source
structural maintenance of chromosomes 389640.0590.2558Yes
74RAD21RAD21
Entrez,  Source
RAD21 homolog (S. pombe)90650.0570.2569Yes
75ZW10ZW10
Entrez,  Source
ZW10, kinetochore associated, homolog (Drosophila)90700.0570.2617Yes
76MCM5MCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)90750.0570.2665Yes
77DCKDCK
Entrez,  Source
deoxycytidine kinase90760.0570.2714Yes
78BRCA2BRCA2
Entrez,  Source
breast cancer 2, early onset90970.0570.2756Yes
79RANBP1RANBP1
Entrez,  Source
RAN binding protein 191000.0570.2804Yes
80PRDX4PRDX4
Entrez,  Source
peroxiredoxin 491130.0560.2848Yes
81HMMRHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)91730.0550.2873Yes
82POLEPOLE
Entrez,  Source
polymerase (DNA directed), epsilon91910.0550.2914Yes
83TACC3TACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 391960.0550.2960Yes
84RACGAP1RACGAP1
Entrez,  Source
Rac GTPase activating protein 192530.0550.2986Yes
85TOP2ATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa92700.0540.3026Yes
86PAICSPAICS
Entrez,  Source
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase93430.0530.3044Yes
87MLH1MLH1
Entrez,  Source
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)93470.0530.3089Yes
88RBBP7RBBP7
Entrez,  Source
retinoblastoma binding protein 794270.0520.3103Yes
89SSRP1SSRP1
Entrez,  Source
structure specific recognition protein 194290.0520.3147Yes
90CCNB2CCNB2
Entrez,  Source
cyclin B294530.0510.3183Yes
91DONSONDONSON
Entrez,  Source
downstream neighbor of SON94890.0510.3213Yes
92PSIP1PSIP1
Entrez,  Source
PC4 and SFRS1 interacting protein 195030.0500.3252Yes
93MSH2MSH2
Entrez,  Source
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)95160.0500.3291Yes
94CENPECENPE
Entrez,  Source
centromere protein E, 312kDa95480.0500.3322Yes
95NAP1L1NAP1L1
Entrez,  Source
nucleosome assembly protein 1-like 195540.0500.3363Yes
96SMC1ASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A96050.0490.3386Yes
97MCM3MCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)96110.0490.3427Yes
98POLD2POLD2
Entrez,  Source
polymerase (DNA directed), delta 2, regulatory subunit 50kDa96810.0480.3441Yes
99POLD3POLD3
Entrez,  Source
polymerase (DNA-directed), delta 3, accessory subunit96980.0480.3477Yes
100HMGB3HMGB3
Entrez,  Source
high-mobility group box 397080.0470.3514Yes
101AURKBAURKB
Entrez,  Source
aurora kinase B97470.0470.3540Yes
102NASPNASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)97570.0470.3577Yes
103H2AFZH2AFZ
Entrez,  Source
H2A histone family, member Z97660.0470.3615Yes
104SNRPBSNRPB
Entrez,  Source
small nuclear ribonucleoprotein polypeptides B and B198100.0460.3638Yes
105PHF5APHF5A
Entrez,  Source
PHD finger protein 5A99370.0450.3628Yes
106DEKDEK
Entrez,  Source
DEK oncogene (DNA binding)99480.0440.3662Yes
107SRSF299660.0440.3694Yes
108POLA2POLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)99680.0440.3732Yes
109MCM7MCM7
Entrez,  Source
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)99930.0440.3760Yes
110CDKN1BCDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)100170.0430.3789Yes
111PPM1DPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform100520.0430.3813Yes
112UBR7100590.0430.3848Yes
113RANRAN
Entrez,  Source
RAN, member RAS oncogene family100620.0430.3884Yes
114GSPT1GSPT1
Entrez,  Source
G1 to S phase transition 1100820.0420.3913Yes
115RFC1RFC1
Entrez,  Source
replication factor C (activator 1) 1, 145kDa100840.0420.3950Yes
116POLD1POLD1
Entrez,  Source
polymerase (DNA directed), delta 1, catalytic subunit 125kDa100860.0420.3986Yes
117HMGB2HMGB2
Entrez,  Source
high-mobility group box 2101070.0420.4015Yes
118CTCFCTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)101230.0420.4045Yes
119PDS5B101370.0420.4076Yes
120SYNCRIPSYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein101520.0410.4107Yes
121CBX5CBX5
Entrez,  Source
chromobox homolog 5 (HP1 alpha homolog, Drosophila)101610.0410.4140Yes
122LUC7L3101860.0410.4166Yes
123PRPS1PRPS1
Entrez,  Source
phosphoribosyl pyrophosphate synthetase 1101970.0410.4198Yes
124TFRCTFRC
Entrez,  Source
transferrin receptor (p90, CD71)102070.0410.4230Yes
125CDCA3CDCA3
Entrez,  Source
cell division cycle associated 3102120.0410.4263Yes
126IPO7IPO7
Entrez,  Source
importin 7102270.0400.4293Yes
127MYBL2MYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 2103680.0390.4272Yes
128BUB1BBUB1B
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)104370.0370.4278Yes
129CDC25BCDC25B
Entrez,  Source
cell division cycle 25B105090.0360.4282Yes
130NOP56105120.0360.4313Yes
131SUV39H1SUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)105240.0360.4340Yes
132BRMS1LBRMS1L
Entrez,  Source
breast cancer metastasis-suppressor 1-like105620.0360.4357Yes
133ORC6105640.0360.4387Yes
134MCM2MCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)106800.0340.4372Yes
135NME1NME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in107970.0330.4356Yes
136PAN2108650.0320.4358Yes
137NCAPD2NCAPD2
Entrez,  Source
non-SMC condensin I complex, subunit D2108920.0320.4375Yes
138HUS1HUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)109210.0310.4391Yes
139PCNAPCNA
Entrez,  Source
proliferating cell nuclear antigen109390.0310.4412Yes
140CDC20CDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)109500.0310.4434Yes
141RFC3RFC3
Entrez,  Source
replication factor C (activator 1) 3, 38kDa110330.0300.4429Yes
142NOLC1NOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 1110530.0300.4447Yes
143PA2G4PA2G4
Entrez,  Source
proliferation-associated 2G4, 38kDa111000.0290.4455Yes
144CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 4111180.0290.4473Yes
145ATAD2ATAD2
Entrez,  Source
ATPase family, AAA domain containing 2111450.0290.4488Yes
146DNMT1DNMT1
Entrez,  Source
DNA (cytosine-5-)-methyltransferase 1111670.0290.4505Yes
147TRA2B111810.0280.4524Yes
148RRM2RRM2
Entrez,  Source
ribonucleotide reductase M2 polypeptide111960.0280.4544Yes
149MRE11AMRE11A
Entrez,  Source
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)112140.0280.4561Yes
150PMS2PMS2
Entrez,  Source
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)112730.0270.4562Yes
151RFC2RFC2
Entrez,  Source
replication factor C (activator 1) 2, 40kDa113280.0270.4564Yes
152EIF2S1EIF2S1
Entrez,  Source
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa113750.0260.4569Yes
153XPO1XPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)114020.0260.4582Yes
154UNGUNG
Entrez,  Source
uracil-DNA glycosylase115140.0240.4560No
155NUP205NUP205
Entrez,  Source
nucleoporin 205kDa115830.0240.4554No
156ESPL1ESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)116720.0230.4539No
157CDKN2CCDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)117950.0210.4510No
158PPP1R8PPP1R8
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 8118310.0210.4515No
159TK1TK1
Entrez,  Source
thymidine kinase 1, soluble118930.0200.4509No
160STMN1STMN1
Entrez,  Source
stathmin 1/oncoprotein 18121350.0170.4430No
161CKS2CKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 2122170.0160.4412No
162CENPMCENPM
Entrez,  Source
centromere protein M122200.0160.4425No
163TUBG1TUBG1
Entrez,  Source
tubulin, gamma 1124920.0130.4331No
164NUP153NUP153
Entrez,  Source
nucleoporin 153kDa125120.0120.4334No
165CDKN3CDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)125680.0120.4323No
166SHMT1SHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)126420.0110.4304No
167UBE2TUBE2T
Entrez,  Source
ubiquitin-conjugating enzyme E2T (putative)126680.0110.4303No
168RPA1RPA1
Entrez,  Source
replication protein A1, 70kDa128700.0080.4232No
169HNRNPD130150.0060.4182No
170POP7POP7
Entrez,  Source
processing of precursor 7, ribonuclease P subunit (S. cerevisiae)132240.0040.4104No
171HN1HN1
Entrez,  Source
hematological and neurological expressed 1132930.0030.4081No
172CTPSCTPS
Entrez,  Source
CTP synthase132960.0030.4082No
173TBRG4TBRG4
Entrez,  Source
transforming growth factor beta regulator 413556-0.0000.3982No
174SPAG5SPAG5
Entrez,  Source
sperm associated antigen 513814-0.0030.3885No
175H2AFXH2AFX
Entrez,  Source
H2A histone family, member X14049-0.0060.3799No
176CDKN1ACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)14264-0.0090.3723No
177CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)14306-0.0090.3715No
178AK2AK2
Entrez,  Source
adenylate kinase 214461-0.0120.3665No
179ILF3ILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa14481-0.0120.3668No
180XRCC6XRCC6
Entrez,  Source
X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)14529-0.0120.3661No
181CDKN2ACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)14958-0.0190.3510No
182RAD51CRAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)15118-0.0210.3467No
183MKI67MKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6715149-0.0220.3474No
184WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)15707-0.0290.3283No
185CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)15717-0.0290.3305No
186EEDEED
Entrez,  Source
embryonic ectoderm development16038-0.0350.3211No
187TCF19TCF19
Entrez,  Source
transcription factor 19 (SC1)16559-0.0400.3043No
188KPNA2KPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)18048-0.0720.2527No
189CCNE1CCNE1
Entrez,  Source
cyclin E118646-0.0890.2372No
190UBE2SUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S18915-0.0970.2352No
191HMGA1HMGA1
Entrez,  Source
high mobility group AT-hook 119069-0.1030.2382No
192PRKDCPRKDC
Entrez,  Source
protein kinase, DNA-activated, catalytic polypeptide19853-0.1340.2193No
193PTTG1PTTG1
Entrez,  Source
pituitary tumor-transforming 120884-0.1820.1951No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_E2F_TARGETS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_E2F_TARGETS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_E2F_TARGETS