Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | -0.78137064 |
| Normalized Enrichment Score (NES) | -1.863205 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.5679985E-5 |
| FWER p-Value | 0.003 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | TRIM21 | TRIM21 Entrez, Source | tripartite motif-containing 21 | 618 | 0.389 | -0.0165 | No |
| 2 | IFITM1 | IFITM1 Entrez, Source | interferon induced transmembrane protein 1 (9-27) | 995 | 0.299 | -0.0252 | No |
| 3 | LAMP3 | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 1475 | 0.233 | -0.0393 | No |
| 4 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 1579 | 0.218 | -0.0391 | No |
| 5 | CCRL2 | CCRL2 Entrez, Source | chemokine (C-C motif) receptor-like 2 | 2039 | 0.172 | -0.0536 | No |
| 6 | NCOA7 | NCOA7 Entrez, Source | nuclear receptor coactivator 7 | 2385 | 0.161 | -0.0638 | No |
| 7 | CXCL11 | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 2436 | 0.157 | -0.0627 | No |
| 8 | STAT2 | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 3441 | 0.099 | -0.0997 | No |
| 9 | SP110 | SP110 Entrez, Source | SP110 nuclear body protein | 9080 | 0.057 | -0.3171 | No |
| 10 | TDRD7 | TDRD7 Entrez, Source | tudor domain containing 7 | 10188 | 0.041 | -0.3592 | No |
| 11 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 10610 | 0.035 | -0.3748 | No |
| 12 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 10821 | 0.033 | -0.3823 | No |
| 13 | LPAR6 | 10861 | 0.032 | -0.3832 | No | ||
| 14 | CNP | CNP Entrez, Source | 2',3'-cyclic nucleotide 3' phosphodiesterase | 11335 | 0.027 | -0.4010 | No |
| 15 | LAP3 | LAP3 Entrez, Source | leucine aminopeptidase 3 | 11434 | 0.025 | -0.4043 | No |
| 16 | CD47 | CD47 Entrez, Source | CD47 molecule | 12202 | 0.016 | -0.4337 | No |
| 17 | IRF2 | IRF2 Entrez, Source | interferon regulatory factor 2 | 12228 | 0.016 | -0.4344 | No |
| 18 | NUB1 | NUB1 Entrez, Source | negative regulator of ubiquitin-like proteins 1 | 12297 | 0.015 | -0.4368 | No |
| 19 | PNPT1 | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 12329 | 0.015 | -0.4377 | No |
| 20 | FAM46A | FAM46A Entrez, Source | family with sequence similarity 46, member A | 12429 | 0.013 | -0.4413 | No |
| 21 | FAM125A | FAM125A Entrez, Source | family with sequence similarity 125, member A | 13884 | -0.004 | -0.4975 | No |
| 22 | OGFR | OGFR Entrez, Source | opioid growth factor receptor | 14197 | -0.008 | -0.5094 | No |
| 23 | TRIM14 | TRIM14 Entrez, Source | tripartite motif-containing 14 | 14280 | -0.009 | -0.5125 | No |
| 24 | TMEM140 | TMEM140 Entrez, Source | transmembrane protein 140 | 14623 | -0.014 | -0.5254 | No |
| 25 | ADAR | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 14749 | -0.016 | -0.5300 | No |
| 26 | PSMA3 | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 15143 | -0.022 | -0.5448 | No |
| 27 | B2M | B2M Entrez, Source | beta-2-microglobulin | 15539 | -0.027 | -0.5596 | No |
| 28 | BATF2 | BATF2 Entrez, Source | basic leucine zipper transcription factor, ATF-like 2 | 16492 | -0.039 | -0.5957 | No |
| 29 | FTSJD2 | 16599 | -0.041 | -0.5990 | No | ||
| 30 | PSME1 | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 17203 | -0.052 | -0.6214 | No |
| 31 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 17473 | -0.058 | -0.6307 | No |
| 32 | IFITM2 | IFITM2 Entrez, Source | interferon induced transmembrane protein 2 (1-8D) | 18119 | -0.074 | -0.6543 | No |
| 33 | MOV10 | MOV10 Entrez, Source | Mov10, Moloney leukemia virus 10, homolog (mouse) | 18149 | -0.075 | -0.6540 | No |
| 34 | UBA7 | 18403 | -0.082 | -0.6622 | No | ||
| 35 | GBP2 | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 18610 | -0.088 | -0.6685 | No |
| 36 | UBE2L6 | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 18633 | -0.089 | -0.6676 | No |
| 37 | SELL | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 18726 | -0.091 | -0.6694 | No |
| 38 | TRAFD1 | TRAFD1 Entrez, Source | TRAF-type zinc finger domain containing 1 | 19019 | -0.101 | -0.6788 | No |
| 39 | SLC25A28 | SLC25A28 Entrez, Source | solute carrier family 25, member 28 | 19038 | -0.102 | -0.6775 | No |
| 40 | PLSCR1 | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 19108 | -0.104 | -0.6782 | No |
| 41 | IFITM3 | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 19157 | -0.106 | -0.6780 | No |
| 42 | CD74 | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 19168 | -0.107 | -0.6763 | No |
| 43 | RNF31 | RNF31 Entrez, Source | ring finger protein 31 | 19259 | -0.110 | -0.6777 | No |
| 44 | TRIM26 | TRIM26 Entrez, Source | tripartite motif-containing 26 | 19314 | -0.112 | -0.6776 | No |
| 45 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 19862 | -0.134 | -0.6962 | No |
| 46 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 20198 | -0.150 | -0.7063 | No |
| 47 | CSF1 | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 21028 | -0.190 | -0.7348 | No |
| 48 | HERC6 | HERC6 Entrez, Source | hect domain and RLD 6 | 21820 | -0.248 | -0.7606 | No |
| 49 | EIF2AK2 | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 21911 | -0.256 | -0.7592 | No |
| 50 | IRF9 | 22485 | -0.307 | -0.7755 | Yes | ||
| 51 | GMPR | GMPR Entrez, Source | guanosine monophosphate reductase | 22516 | -0.310 | -0.7706 | Yes |
| 52 | IL15 | IL15 Entrez, Source | interleukin 15 | 22561 | -0.316 | -0.7663 | Yes |
| 53 | LY6E | LY6E Entrez, Source | lymphocyte antigen 6 complex, locus E | 22607 | -0.320 | -0.7618 | Yes |
| 54 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 22778 | -0.338 | -0.7619 | Yes |
| 55 | BST2 | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 22902 | -0.355 | -0.7598 | Yes |
| 56 | CMPK2 | 23278 | -0.403 | -0.7666 | Yes | ||
| 57 | TRIM5 | TRIM5 Entrez, Source | tripartite motif-containing 5 | 23487 | -0.433 | -0.7663 | Yes |
| 58 | EPSTI1 | EPSTI1 Entrez, Source | epithelial stromal interaction 1 (breast) | 23538 | -0.439 | -0.7598 | Yes |
| 59 | PARP12 | PARP12 Entrez, Source | poly (ADP-ribose) polymerase family, member 12 | 23548 | -0.441 | -0.7517 | Yes |
| 60 | PSME2 | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 23724 | -0.470 | -0.7494 | Yes |
| 61 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 23939 | -0.510 | -0.7478 | Yes |
| 62 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 23972 | -0.516 | -0.7391 | Yes |
| 63 | PARP9 | PARP9 Entrez, Source | poly (ADP-ribose) polymerase family, member 9 | 24171 | -0.559 | -0.7360 | Yes |
| 64 | TAP1 | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 24212 | -0.568 | -0.7266 | Yes |
| 65 | DHX58 | 24511 | -0.647 | -0.7257 | Yes | ||
| 66 | C1S | C1S Entrez, Source | complement component 1, s subcomponent | 24554 | -0.664 | -0.7145 | Yes |
| 67 | IFIT2 | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 24672 | -0.695 | -0.7057 | Yes |
| 68 | RIPK2 | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 24935 | -0.789 | -0.7006 | Yes |
| 69 | TRIM25 | TRIM25 Entrez, Source | tripartite motif-containing 25 | 25023 | -0.834 | -0.6879 | Yes |
| 70 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 25437 | -1.129 | -0.6822 | Yes |
| 71 | PROCR | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 25463 | -1.158 | -0.6608 | Yes |
| 72 | IL7 | IL7 Entrez, Source | interleukin 7 | 25620 | -1.382 | -0.6402 | Yes |
| 73 | IFI35 | IFI35 Entrez, Source | interferon-induced protein 35 | 25621 | -1.385 | -0.6135 | Yes |
| 74 | PARP14 | PARP14 Entrez, Source | poly (ADP-ribose) polymerase family, member 14 | 25624 | -1.394 | -0.5867 | Yes |
| 75 | GBP4 | GBP4 Entrez, Source | guanylate binding protein 4 | 25655 | -1.448 | -0.5600 | Yes |
| 76 | ISG15 | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 25699 | -1.594 | -0.5309 | Yes |
| 77 | DDX60 | 25710 | -1.643 | -0.4997 | Yes | ||
| 78 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 25743 | -1.742 | -0.4673 | Yes |
| 79 | LGALS3BP | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 25761 | -1.839 | -0.4325 | Yes |
| 80 | PSMB9 | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 25769 | -1.855 | -0.3970 | Yes |
| 81 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 25794 | -2.009 | -0.3593 | Yes |
| 82 | RSAD2 | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 25795 | -2.013 | -0.3205 | Yes |
| 83 | IFIH1 | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 25804 | -2.052 | -0.2812 | Yes |
| 84 | USP18 | USP18 Entrez, Source | ubiquitin specific peptidase 18 | 25830 | -2.231 | -0.2392 | Yes |
| 85 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 25831 | -2.278 | -0.1953 | Yes |
| 86 | RTP4 | RTP4 Entrez, Source | receptor transporter protein 4 | 25833 | -2.300 | -0.1510 | Yes |
| 87 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 25838 | -2.365 | -0.1055 | Yes |
| 88 | IFIT3 | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 25844 | -2.414 | -0.0592 | Yes |
| 89 | SAMD9L | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 25888 | -3.178 | 0.0004 | Yes |
