Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | HECKER_IFNB1_TARGETS |
| Enrichment Score (ES) | -0.7754281 |
| Normalized Enrichment Score (NES) | -1.8231717 |
| Nominal p-value | 0.0 |
| FDR q-value | 5.3316064E-4 |
| FWER p-Value | 0.02 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SIGLEC1 | SIGLEC1 Entrez, Source | sialic acid binding Ig-like lectin 1, sialoadhesin | 114 | 0.750 | 0.0119 | No |
| 2 | G0S2 | G0S2 Entrez, Source | G0/G1switch 2 | 1078 | 0.283 | -0.0192 | No |
| 3 | LAMP3 | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 1475 | 0.233 | -0.0295 | No |
| 4 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 1488 | 0.232 | -0.0249 | No |
| 5 | CMTM5 | CMTM5 Entrez, Source | CKLF-like MARVEL transmembrane domain containing 5 | 1598 | 0.215 | -0.0244 | No |
| 6 | CABP5 | CABP5 Entrez, Source | calcium binding protein 5 | 2376 | 0.162 | -0.0510 | No |
| 7 | C3AR1 | C3AR1 Entrez, Source | complement component 3a receptor 1 | 2518 | 0.150 | -0.0532 | No |
| 8 | ZBP1 | ZBP1 Entrez, Source | Z-DNA binding protein 1 | 4016 | 0.085 | -0.1093 | No |
| 9 | RPS23 | RPS23 Entrez, Source | ribosomal protein S23 | 4177 | 0.079 | -0.1138 | No |
| 10 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 5111 | 0.074 | -0.1483 | No |
| 11 | FFAR2 | FFAR2 Entrez, Source | free fatty acid receptor 2 | 5274 | 0.074 | -0.1529 | No |
| 12 | CCL8 | CCL8 Entrez, Source | chemokine (C-C motif) ligand 8 | 5906 | 0.074 | -0.1758 | No |
| 13 | FCER1A | FCER1A Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 6059 | 0.074 | -0.1800 | No |
| 14 | GZMB | GZMB Entrez, Source | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 6421 | 0.074 | -0.1924 | No |
| 15 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 8233 | 0.069 | -0.2610 | No |
| 16 | SPON2 | SPON2 Entrez, Source | spondin 2, extracellular matrix protein | 8635 | 0.061 | -0.2752 | No |
| 17 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 8736 | 0.060 | -0.2778 | No |
| 18 | TREML1 | TREML1 Entrez, Source | triggering receptor expressed on myeloid cells-like 1 | 8823 | 0.060 | -0.2798 | No |
| 19 | OAS3 | OAS3 Entrez, Source | 2'-5'-oligoadenylate synthetase 3, 100kDa | 9242 | 0.055 | -0.2948 | No |
| 20 | EGR1 | EGR1 Entrez, Source | early growth response 1 | 10502 | 0.037 | -0.3428 | No |
| 21 | GBP1 | GBP1 Entrez, Source | guanylate binding protein 1, interferon-inducible, 67kDa | 10631 | 0.035 | -0.3470 | No |
| 22 | TNFAIP6 | TNFAIP6 Entrez, Source | tumor necrosis factor, alpha-induced protein 6 | 11179 | 0.028 | -0.3675 | No |
| 23 | LAP3 | LAP3 Entrez, Source | leucine aminopeptidase 3 | 11434 | 0.025 | -0.3768 | No |
| 24 | PNPT1 | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 12329 | 0.015 | -0.4111 | No |
| 25 | SCO2 | SCO2 Entrez, Source | SCO cytochrome oxidase deficient homolog 2 (yeast) | 13958 | -0.005 | -0.4740 | No |
| 26 | TMEM140 | TMEM140 Entrez, Source | transmembrane protein 140 | 14623 | -0.014 | -0.4995 | No |
| 27 | TYMP | 14791 | -0.016 | -0.5056 | No | ||
| 28 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 15281 | -0.024 | -0.5240 | No |
| 29 | ARG1 | ARG1 Entrez, Source | arginase, liver | 15563 | -0.027 | -0.5343 | No |
| 30 | EGR2 | EGR2 Entrez, Source | early growth response 2 (Krox-20 homolog, Drosophila) | 15896 | -0.032 | -0.5464 | No |
| 31 | JUP | JUP Entrez, Source | junction plakoglobin | 17084 | -0.050 | -0.5913 | No |
| 32 | STAP1 | 17271 | -0.054 | -0.5973 | No | ||
| 33 | PROS1 | PROS1 Entrez, Source | protein S (alpha) | 17276 | -0.054 | -0.5963 | No |
| 34 | MYL9 | MYL9 Entrez, Source | myosin, light chain 9, regulatory | 18674 | -0.090 | -0.6485 | No |
| 35 | PLSCR1 | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 19108 | -0.104 | -0.6629 | No |
| 36 | SH3BGRL2 | SH3BGRL2 Entrez, Source | SH3 domain binding glutamic acid-rich protein like 2 | 19778 | -0.131 | -0.6860 | No |
| 37 | CD163 | CD163 Entrez, Source | CD163 molecule | 20126 | -0.146 | -0.6963 | No |
| 38 | GP9 | GP9 Entrez, Source | glycoprotein IX (platelet) | 21116 | -0.197 | -0.7303 | No |
| 39 | HERC6 | HERC6 Entrez, Source | hect domain and RLD 6 | 21820 | -0.248 | -0.7521 | No |
| 40 | EIF2AK2 | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 21911 | -0.256 | -0.7500 | No |
| 41 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 22091 | -0.270 | -0.7511 | No |
| 42 | PDZK1IP1 | PDZK1IP1 Entrez, Source | PDZK1 interacting protein 1 | 22507 | -0.309 | -0.7604 | No |
| 43 | LY6E | LY6E Entrez, Source | lymphocyte antigen 6 complex, locus E | 22607 | -0.320 | -0.7573 | No |
| 44 | CLU | CLU Entrez, Source | clusterin | 22619 | -0.322 | -0.7507 | No |
| 45 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 23259 | -0.399 | -0.7667 | Yes |
| 46 | CMPK2 | 23278 | -0.403 | -0.7587 | Yes | ||
| 47 | EPSTI1 | EPSTI1 Entrez, Source | epithelial stromal interaction 1 (breast) | 23538 | -0.439 | -0.7591 | Yes |
| 48 | PARP12 | PARP12 Entrez, Source | poly (ADP-ribose) polymerase family, member 12 | 23548 | -0.441 | -0.7499 | Yes |
| 49 | ITGA2B | ITGA2B Entrez, Source | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 23645 | -0.456 | -0.7437 | Yes |
| 50 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 23939 | -0.510 | -0.7439 | Yes |
| 51 | KLRD1 | KLRD1 Entrez, Source | killer cell lectin-like receptor subfamily D, member 1 | 24091 | -0.539 | -0.7380 | Yes |
| 52 | DDX58 | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 24122 | -0.545 | -0.7273 | Yes |
| 53 | PARP9 | PARP9 Entrez, Source | poly (ADP-ribose) polymerase family, member 9 | 24171 | -0.559 | -0.7170 | Yes |
| 54 | DHX58 | 24511 | -0.647 | -0.7160 | Yes | ||
| 55 | DTX3L | DTX3L Entrez, Source | deltex 3-like (Drosophila) | 24573 | -0.670 | -0.7038 | Yes |
| 56 | IFIT2 | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 24672 | -0.695 | -0.6925 | Yes |
| 57 | MMP25 | MMP25 Entrez, Source | matrix metallopeptidase 25 | 24791 | -0.732 | -0.6811 | Yes |
| 58 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 25221 | -0.943 | -0.6772 | Yes |
| 59 | MX2 | MX2 Entrez, Source | myxovirus (influenza virus) resistance 2 (mouse) | 25230 | -0.948 | -0.6569 | Yes |
| 60 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 25269 | -0.979 | -0.6370 | Yes |
| 61 | MGAM | MGAM Entrez, Source | maltase-glucoamylase (alpha-glucosidase) | 25354 | -1.049 | -0.6174 | Yes |
| 62 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 25437 | -1.129 | -0.5960 | Yes |
| 63 | OAS2 | OAS2 Entrez, Source | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 25558 | -1.284 | -0.5727 | Yes |
| 64 | IFI35 | IFI35 Entrez, Source | interferon-induced protein 35 | 25621 | -1.385 | -0.5449 | Yes |
| 65 | ISG15 | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 25699 | -1.594 | -0.5132 | Yes |
| 66 | DDX60 | 25710 | -1.643 | -0.4778 | Yes | ||
| 67 | LGALS3BP | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 25761 | -1.839 | -0.4397 | Yes |
| 68 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 25794 | -2.009 | -0.3972 | Yes |
| 69 | RSAD2 | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 25795 | -2.013 | -0.3534 | Yes |
| 70 | XAF1 | 25822 | -2.156 | -0.3074 | Yes | ||
| 71 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 25831 | -2.278 | -0.2581 | Yes |
| 72 | RTP4 | RTP4 Entrez, Source | receptor transporter protein 4 | 25833 | -2.300 | -0.2081 | Yes |
| 73 | IFIT3 | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 25844 | -2.414 | -0.1559 | Yes |
| 74 | SAMD9L | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 25888 | -3.178 | -0.0883 | Yes |
| 75 | IFIT1 | IFIT1 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 1 | 25894 | -4.073 | 0.0002 | Yes |
