Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | -0.79136634 |
| Normalized Enrichment Score (NES) | -1.8009431 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0011206893 |
| FWER p-Value | 0.05 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PTPN6 | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 243 | 0.575 | 0.0108 | No |
| 2 | IFITM1 | IFITM1 Entrez, Source | interferon induced transmembrane protein 1 (9-27) | 995 | 0.299 | -0.0077 | No |
| 3 | IRF6 | IRF6 Entrez, Source | interferon regulatory factor 6 | 1395 | 0.242 | -0.0146 | No |
| 4 | IFNA2 | IFNA2 Entrez, Source | interferon, alpha 2 | 1566 | 0.221 | -0.0134 | No |
| 5 | IFNA7 | IFNA7 Entrez, Source | interferon, alpha 7 | 2241 | 0.164 | -0.0337 | No |
| 6 | IFNA4 | IFNA4 Entrez, Source | interferon, alpha 4 | 2321 | 0.164 | -0.0310 | No |
| 7 | STAT2 | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 3441 | 0.099 | -0.0708 | No |
| 8 | IRF5 | IRF5 Entrez, Source | interferon regulatory factor 5 | 3722 | 0.088 | -0.0786 | No |
| 9 | IRF4 | IRF4 Entrez, Source | interferon regulatory factor 4 | 3990 | 0.086 | -0.0859 | No |
| 10 | IFNA14 | IFNA14 Entrez, Source | interferon, alpha 14 | 4895 | 0.074 | -0.1182 | No |
| 11 | IFNA5 | IFNA5 Entrez, Source | interferon, alpha 5 | 6644 | 0.074 | -0.1832 | No |
| 12 | IFNA6 | IFNA6 Entrez, Source | interferon, alpha 6 | 6645 | 0.074 | -0.1806 | No |
| 13 | IFNA1 | IFNA1 Entrez, Source | interferon, alpha 1 | 6646 | 0.074 | -0.1780 | No |
| 14 | IFNB1 | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 6656 | 0.074 | -0.1758 | No |
| 15 | OAS3 | OAS3 Entrez, Source | 2'-5'-oligoadenylate synthetase 3, 100kDa | 9242 | 0.055 | -0.2738 | No |
| 16 | IRF3 | IRF3 Entrez, Source | interferon regulatory factor 3 | 9775 | 0.046 | -0.2928 | No |
| 17 | EGR1 | EGR1 Entrez, Source | early growth response 1 | 10502 | 0.037 | -0.3196 | No |
| 18 | IFNAR2 | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 11944 | 0.020 | -0.3746 | No |
| 19 | PTPN1 | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 12123 | 0.017 | -0.3809 | No |
| 20 | IRF2 | IRF2 Entrez, Source | interferon regulatory factor 2 | 12228 | 0.016 | -0.3844 | No |
| 21 | ADAR | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 14749 | -0.016 | -0.4813 | No |
| 22 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 14776 | -0.016 | -0.4817 | No |
| 23 | IP6K2 | 14923 | -0.018 | -0.4868 | No | ||
| 24 | IFNAR1 | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 15687 | -0.029 | -0.5152 | No |
| 25 | IFITM2 | IFITM2 Entrez, Source | interferon induced transmembrane protein 2 (1-8D) | 18119 | -0.074 | -0.6067 | No |
| 26 | GBP2 | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 18610 | -0.088 | -0.6226 | No |
| 27 | IFITM3 | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 19157 | -0.106 | -0.6399 | No |
| 28 | TYK2 | TYK2 Entrez, Source | tyrosine kinase 2 | 19799 | -0.132 | -0.6601 | No |
| 29 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 19862 | -0.134 | -0.6578 | No |
| 30 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 21149 | -0.199 | -0.7005 | No |
| 31 | IRF8 | IRF8 Entrez, Source | interferon regulatory factor 8 | 21749 | -0.243 | -0.7152 | No |
| 32 | IRF9 | 22485 | -0.307 | -0.7328 | No | ||
| 33 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 22778 | -0.338 | -0.7322 | No |
| 34 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 23259 | -0.399 | -0.7367 | No |
| 35 | IFIT2 | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 24672 | -0.695 | -0.7669 | Yes |
| 36 | MX2 | MX2 Entrez, Source | myxovirus (influenza virus) resistance 2 (mouse) | 25230 | -0.948 | -0.7552 | Yes |
| 37 | SOCS1 | SOCS1 Entrez, Source | suppressor of cytokine signaling 1 | 25388 | -1.079 | -0.7233 | Yes |
| 38 | RNASEL | RNASEL Entrez, Source | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | 25409 | -1.107 | -0.6852 | Yes |
| 39 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 25437 | -1.129 | -0.6465 | Yes |
| 40 | OAS2 | OAS2 Entrez, Source | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 25558 | -1.284 | -0.6060 | Yes |
| 41 | IFI35 | IFI35 Entrez, Source | interferon-induced protein 35 | 25621 | -1.385 | -0.5597 | Yes |
| 42 | ISG15 | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 25699 | -1.594 | -0.5067 | Yes |
| 43 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 25743 | -1.742 | -0.4471 | Yes |
| 44 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 25794 | -2.009 | -0.3784 | Yes |
| 45 | XAF1 | 25822 | -2.156 | -0.3037 | Yes | ||
| 46 | USP18 | USP18 Entrez, Source | ubiquitin specific peptidase 18 | 25830 | -2.231 | -0.2255 | Yes |
| 47 | IFIT3 | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 25844 | -2.414 | -0.1411 | Yes |
| 48 | IFIT1 | IFIT1 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 1 | 25894 | -4.073 | 0.0002 | Yes |
