Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | SANA_RESPONSE_TO_IFNG_UP |
| Enrichment Score (ES) | -0.800329 |
| Normalized Enrichment Score (NES) | -1.8489088 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.0336398E-4 |
| FWER p-Value | 0.007 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ATP6V0A4 | ATP6V0A4 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a4 | 383 | 0.482 | -0.0004 | No |
| 2 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 1579 | 0.218 | -0.0400 | No |
| 3 | CXCL11 | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 2436 | 0.157 | -0.0684 | No |
| 4 | CFH | CFH Entrez, Source | complement factor H | 2846 | 0.132 | -0.0803 | No |
| 5 | HAUS7 | 4060 | 0.083 | -0.1247 | No | ||
| 6 | GATA5 | GATA5 Entrez, Source | GATA binding protein 5 | 5470 | 0.074 | -0.1770 | No |
| 7 | GIMAP7 | GIMAP7 Entrez, Source | GTPase, IMAP family member 7 | 6692 | 0.074 | -0.2220 | No |
| 8 | IL23A | IL23A Entrez, Source | interleukin 23, alpha subunit p19 | 9422 | 0.052 | -0.3261 | No |
| 9 | PLA1A | PLA1A Entrez, Source | phospholipase A1 member A | 10085 | 0.042 | -0.3504 | No |
| 10 | TNFSF10 | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 10244 | 0.040 | -0.3553 | No |
| 11 | GBP1 | GBP1 Entrez, Source | guanylate binding protein 1, interferon-inducible, 67kDa | 10631 | 0.035 | -0.3692 | No |
| 12 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 10821 | 0.033 | -0.3756 | No |
| 13 | LAP3 | LAP3 Entrez, Source | leucine aminopeptidase 3 | 11434 | 0.025 | -0.3985 | No |
| 14 | SAMHD1 | SAMHD1 Entrez, Source | SAM domain and HD domain 1 | 12750 | 0.010 | -0.4491 | No |
| 15 | ST8SIA4 | ST8SIA4 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 12951 | 0.007 | -0.4566 | No |
| 16 | GBP3 | GBP3 Entrez, Source | guanylate binding protein 3 | 13009 | 0.006 | -0.4586 | No |
| 17 | RABL3 | RABL3 Entrez, Source | RAB, member of RAS oncogene family-like 3 | 13034 | 0.006 | -0.4594 | No |
| 18 | GOLM1 | 14124 | -0.007 | -0.5013 | No | ||
| 19 | PPP3CA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 14978 | -0.019 | -0.5337 | No |
| 20 | BATF2 | BATF2 Entrez, Source | basic leucine zipper transcription factor, ATF-like 2 | 16492 | -0.039 | -0.5911 | No |
| 21 | IL18BP | IL18BP Entrez, Source | interleukin 18 binding protein | 17990 | -0.071 | -0.6469 | No |
| 22 | CXCL9 | CXCL9 Entrez, Source | chemokine (C-X-C motif) ligand 9 | 18183 | -0.076 | -0.6521 | No |
| 23 | UBE2L6 | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 18633 | -0.089 | -0.6668 | No |
| 24 | SSPN | SSPN Entrez, Source | sarcospan (Kras oncogene-associated gene) | 18687 | -0.090 | -0.6661 | No |
| 25 | SLC25A28 | SLC25A28 Entrez, Source | solute carrier family 25, member 28 | 19038 | -0.102 | -0.6766 | No |
| 26 | UBD | UBD Entrez, Source | ubiquitin D | 19881 | -0.135 | -0.7052 | No |
| 27 | HSD17B11 | 20660 | -0.170 | -0.7302 | No | ||
| 28 | IDO1 | 20686 | -0.171 | -0.7260 | No | ||
| 29 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 22608 | -0.320 | -0.7907 | Yes |
| 30 | RAC3 | RAC3 Entrez, Source | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 22856 | -0.349 | -0.7898 | Yes |
| 31 | BST2 | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 22902 | -0.355 | -0.7809 | Yes |
| 32 | LIPG | LIPG Entrez, Source | lipase, endothelial | 23404 | -0.420 | -0.7876 | Yes |
| 33 | MLKL | MLKL Entrez, Source | mixed lineage kinase domain-like | 23532 | -0.439 | -0.7794 | Yes |
| 34 | RNF213 | 23919 | -0.506 | -0.7791 | Yes | ||
| 35 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 23939 | -0.510 | -0.7645 | Yes |
| 36 | PARP9 | PARP9 Entrez, Source | poly (ADP-ribose) polymerase family, member 9 | 24171 | -0.559 | -0.7567 | Yes |
| 37 | CEACAM1 | CEACAM1 Entrez, Source | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 24306 | -0.589 | -0.7442 | Yes |
| 38 | C1S | C1S Entrez, Source | complement component 1, s subcomponent | 24554 | -0.664 | -0.7338 | Yes |
| 39 | DTX3L | DTX3L Entrez, Source | deltex 3-like (Drosophila) | 24573 | -0.670 | -0.7144 | Yes |
| 40 | MMP25 | MMP25 Entrez, Source | matrix metallopeptidase 25 | 24791 | -0.732 | -0.7008 | Yes |
| 41 | VAMP5 | VAMP5 Entrez, Source | vesicle-associated membrane protein 5 (myobrevin) | 25253 | -0.967 | -0.6896 | Yes |
| 42 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 25269 | -0.979 | -0.6608 | Yes |
| 43 | CD274 | CD274 Entrez, Source | CD274 molecule | 25335 | -1.036 | -0.6322 | Yes |
| 44 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 25437 | -1.129 | -0.6022 | Yes |
| 45 | OAS2 | OAS2 Entrez, Source | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 25558 | -1.284 | -0.5683 | Yes |
| 46 | LGALS9 | LGALS9 Entrez, Source | lectin, galactoside-binding, soluble, 9 (galectin 9) | 25596 | -1.336 | -0.5296 | Yes |
| 47 | IFI35 | IFI35 Entrez, Source | interferon-induced protein 35 | 25621 | -1.385 | -0.4889 | Yes |
| 48 | PARP14 | PARP14 Entrez, Source | poly (ADP-ribose) polymerase family, member 14 | 25624 | -1.394 | -0.4472 | Yes |
| 49 | GBP4 | GBP4 Entrez, Source | guanylate binding protein 4 | 25655 | -1.448 | -0.4049 | Yes |
| 50 | DDX60 | 25710 | -1.643 | -0.3576 | Yes | ||
| 51 | LGALS3BP | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 25761 | -1.839 | -0.3043 | Yes |
| 52 | IFIH1 | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 25804 | -2.052 | -0.2443 | Yes |
| 53 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 25838 | -2.365 | -0.1746 | Yes |
| 54 | NLRC5 | 25867 | -2.711 | -0.0943 | Yes | ||
| 55 | SAMD9L | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 25888 | -3.178 | 0.0004 | Yes |
