Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP |
| Enrichment Score (ES) | -0.791811 |
| Normalized Enrichment Score (NES) | -1.8633779 |
| Nominal p-value | 0.0 |
| FDR q-value | 9.8869314E-5 |
| FWER p-Value | 0.003 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GPRC5A | GPRC5A Entrez, Source | G protein-coupled receptor, family C, group 5, member A | 1289 | 0.255 | -0.0426 | No |
| 2 | CCNE2 | CCNE2 Entrez, Source | cyclin E2 | 2122 | 0.165 | -0.0702 | No |
| 3 | MAGEA6 | MAGEA6 Entrez, Source | melanoma antigen family A, 6 | 2288 | 0.164 | -0.0719 | No |
| 4 | CXCL11 | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 2436 | 0.157 | -0.0731 | No |
| 5 | HS3ST1 | HS3ST1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 2499 | 0.151 | -0.0712 | No |
| 6 | ADAM28 | ADAM28 Entrez, Source | ADAM metallopeptidase domain 28 | 3434 | 0.099 | -0.1046 | No |
| 7 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 3735 | 0.088 | -0.1137 | No |
| 8 | MAPRE2 | MAPRE2 Entrez, Source | microtubule-associated protein, RP/EB family, member 2 | 4126 | 0.081 | -0.1265 | No |
| 9 | TFF1 | TFF1 Entrez, Source | trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) | 5277 | 0.074 | -0.1689 | No |
| 10 | MAGEA3 | MAGEA3 Entrez, Source | melanoma antigen family A, 3 | 7740 | 0.074 | -0.2621 | No |
| 11 | PTN | PTN Entrez, Source | pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) | 8571 | 0.063 | -0.2924 | No |
| 12 | SEMA3A | SEMA3A Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 9613 | 0.049 | -0.3313 | No |
| 13 | GBP1 | GBP1 Entrez, Source | guanylate binding protein 1, interferon-inducible, 67kDa | 10631 | 0.035 | -0.3697 | No |
| 14 | TMEM50A | TMEM50A Entrez, Source | transmembrane protein 50A | 11755 | 0.022 | -0.4126 | No |
| 15 | ZFP36L2 | ZFP36L2 Entrez, Source | zinc finger protein 36, C3H type-like 2 | 12107 | 0.018 | -0.4256 | No |
| 16 | FAM46A | FAM46A Entrez, Source | family with sequence similarity 46, member A | 12429 | 0.013 | -0.4377 | No |
| 17 | SORD | SORD Entrez, Source | sorbitol dehydrogenase | 12956 | 0.007 | -0.4578 | No |
| 18 | KLF4 | KLF4 Entrez, Source | Kruppel-like factor 4 (gut) | 13311 | 0.003 | -0.4715 | No |
| 19 | TMEM70 | TMEM70 Entrez, Source | transmembrane protein 70 | 13589 | -0.001 | -0.4822 | No |
| 20 | ALDH1A3 | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 14380 | -0.010 | -0.5125 | No |
| 21 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 14629 | -0.014 | -0.5217 | No |
| 22 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 14947 | -0.019 | -0.5334 | No |
| 23 | ABCG2 | ABCG2 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 2 | 15535 | -0.027 | -0.5554 | No |
| 24 | ZC3HAV1 | ZC3HAV1 Entrez, Source | zinc finger CCCH-type, antiviral 1 | 15792 | -0.031 | -0.5644 | No |
| 25 | DAAM1 | DAAM1 Entrez, Source | dishevelled associated activator of morphogenesis 1 | 15949 | -0.033 | -0.5695 | No |
| 26 | EVI2B | EVI2B Entrez, Source | ecotropic viral integration site 2B | 16641 | -0.042 | -0.5951 | No |
| 27 | PDLIM5 | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 16657 | -0.042 | -0.5945 | No |
| 28 | NDP | NDP Entrez, Source | Norrie disease (pseudoglioma) | 16895 | -0.047 | -0.6023 | No |
| 29 | PTGER4 | PTGER4 Entrez, Source | prostaglandin E receptor 4 (subtype EP4) | 17194 | -0.052 | -0.6124 | No |
| 30 | CRISPLD2 | CRISPLD2 Entrez, Source | cysteine-rich secretory protein LCCL domain containing 2 | 17471 | -0.058 | -0.6214 | No |
| 31 | EFNB2 | EFNB2 Entrez, Source | ephrin-B2 | 18875 | -0.096 | -0.6730 | No |
| 32 | PNP | 18959 | -0.099 | -0.6734 | No | ||
| 33 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 19862 | -0.134 | -0.7045 | No |
| 34 | BCHE | BCHE Entrez, Source | butyrylcholinesterase | 20020 | -0.140 | -0.7066 | No |
| 35 | MALL | MALL Entrez, Source | mal, T-cell differentiation protein-like | 20084 | -0.143 | -0.7049 | No |
| 36 | IDO1 | 20686 | -0.171 | -0.7234 | No | ||
| 37 | HERC6 | HERC6 Entrez, Source | hect domain and RLD 6 | 21820 | -0.248 | -0.7602 | No |
| 38 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 22450 | -0.303 | -0.7759 | No |
| 39 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 22608 | -0.320 | -0.7729 | No |
| 40 | CLU | CLU Entrez, Source | clusterin | 22619 | -0.322 | -0.7641 | No |
| 41 | SLIT2 | SLIT2 Entrez, Source | slit homolog 2 (Drosophila) | 23257 | -0.399 | -0.7774 | Yes |
| 42 | LIPG | LIPG Entrez, Source | lipase, endothelial | 23404 | -0.420 | -0.7711 | Yes |
| 43 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 23939 | -0.510 | -0.7773 | Yes |
| 44 | DDX58 | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 24122 | -0.545 | -0.7689 | Yes |
| 45 | CCL5 | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 24336 | -0.598 | -0.7601 | Yes |
| 46 | HPSE | HPSE Entrez, Source | heparanase | 24426 | -0.626 | -0.7458 | Yes |
| 47 | IGFBP6 | IGFBP6 Entrez, Source | insulin-like growth factor binding protein 6 | 24494 | -0.641 | -0.7301 | Yes |
| 48 | IFIT2 | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 24672 | -0.695 | -0.7172 | Yes |
| 49 | NMU | NMU Entrez, Source | neuromedin U | 24684 | -0.698 | -0.6978 | Yes |
| 50 | MX2 | MX2 Entrez, Source | myxovirus (influenza virus) resistance 2 (mouse) | 25230 | -0.948 | -0.6920 | Yes |
| 51 | CH25H | CH25H Entrez, Source | cholesterol 25-hydroxylase | 25282 | -0.988 | -0.6659 | Yes |
| 52 | BMP4 | BMP4 Entrez, Source | bone morphogenetic protein 4 | 25306 | -1.012 | -0.6380 | Yes |
| 53 | SPOCK1 | SPOCK1 Entrez, Source | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 25311 | -1.016 | -0.6093 | Yes |
| 54 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 25437 | -1.129 | -0.5820 | Yes |
| 55 | SORL1 | SORL1 Entrez, Source | sortilin-related receptor, L(DLR class) A repeats-containing | 25475 | -1.171 | -0.5502 | Yes |
| 56 | TLR4 | TLR4 Entrez, Source | toll-like receptor 4 | 25544 | -1.260 | -0.5170 | Yes |
| 57 | OAS2 | OAS2 Entrez, Source | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 25558 | -1.284 | -0.4810 | Yes |
| 58 | PRR16 | PRR16 Entrez, Source | proline rich 16 | 25672 | -1.495 | -0.4429 | Yes |
| 59 | ISG15 | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 25699 | -1.594 | -0.3986 | Yes |
| 60 | DDX60 | 25710 | -1.643 | -0.3523 | Yes | ||
| 61 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 25759 | -1.830 | -0.3022 | Yes |
| 62 | IFIH1 | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 25804 | -2.052 | -0.2456 | Yes |
| 63 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 25831 | -2.278 | -0.1818 | Yes |
| 64 | IFIT3 | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 25844 | -2.414 | -0.1137 | Yes |
| 65 | IFIT1 | IFIT1 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 1 | 25894 | -4.073 | 0.0002 | Yes |
