DatasetSMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls
#del_versus_fl.SMCHD1_KO.cls
#del_versus_fl_repos
PhenotypeSMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class1
GeneSetTAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP
Enrichment Score (ES)-0.74486345
Normalized Enrichment Score (NES)-1.8066323
Nominal p-value0.0
FDR q-value8.659147E-4
FWER p-Value0.036
Table: GSEA Results Summary



Fig 1: Enrichment plot: TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1TSLPTSLP
Entrez,  Source
-5320.414-0.0151No
2GPR124GPR124
Entrez,  Source
G protein-coupled receptor 1248470.329-0.0229No
3MED18MED18
Entrez,  Source
mediator of RNA polymerase II transcription, subunit 18 homolog (S. cerevisiae)9200.315-0.0214No
4IFITM1IFITM1
Entrez,  Source
interferon induced transmembrane protein 1 (9-27)9950.299-0.0203No
5HOXA9HOXA9
Entrez,  Source
homeobox A911280.275-0.0217No
6GALNT12GALNT12
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)11700.269-0.0197No
7DHRS9DHRS9
Entrez,  Source
dehydrogenase/reductase (SDR family) member 914850.232-0.0288No
8CDKN1CCDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)14890.232-0.0257No
9IL31RAIL31RA
Entrez,  Source
interleukin 31 receptor A19620.178-0.0417No
10EPCAM20060.176-0.0410No
11SLC27A6SLC27A6
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 621230.165-0.0433No
12HOPX27520.137-0.0658No
13ASB2ASB2
Entrez,  Source
ankyrin repeat and SOCS box-containing 237830.086-0.1047No
14INPP4BINPP4B
Entrez,  Source
inositol polyphosphate-4-phosphatase, type II, 105kDa42560.077-0.1220No
15CFDCFD
Entrez,  Source
complement factor D (adipsin)44430.074-0.1282No
16LILRA5LILRA5
Entrez,  Source
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 554590.074-0.1667No
17IL22RA2IL22RA2
Entrez,  Source
interleukin 22 receptor, alpha 255840.074-0.1705No
18CHRNA6CHRNA6
Entrez,  Source
cholinergic receptor, nicotinic, alpha 666580.074-0.2112No
19AUTS2AUTS2
Entrez,  Source
autism susceptibility candidate 279980.073-0.2622No
20MCM4MCM4
Entrez,  Source
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)85820.062-0.2840No
21HOXA7HOXA7
Entrez,  Source
homeobox A788560.060-0.2938No
22SP110SP110
Entrez,  Source
SP110 nuclear body protein90800.057-0.3017No
23OAS3OAS3
Entrez,  Source
2'-5'-oligoadenylate synthetase 3, 100kDa92420.055-0.3072No
24SERPINE2SERPINE2
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 293030.054-0.3088No
25HMGCS1HMGCS1
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)93180.053-0.3087No
26TEX9TEX9
Entrez,  Source
testis expressed sequence 993280.053-0.3083No
27HPGDHPGD
Entrez,  Source
hydroxyprostaglandin dehydrogenase 15-(NAD)95930.049-0.3179No
28USTUST
Entrez,  Source
uronyl-2-sulfotransferase98950.045-0.3290No
29TYRP1TYRP1
Entrez,  Source
tyrosinase-related protein 199770.044-0.3315No
30ARL4AARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A106200.035-0.3560No
31GBP1GBP1
Entrez,  Source
guanylate binding protein 1, interferon-inducible, 67kDa106310.035-0.3559No
32CKBCKB
Entrez,  Source
creatine kinase, brain107170.034-0.3588No
33EGLN3EGLN3
Entrez,  Source
egl nine homolog 3 (C. elegans)108110.033-0.3619No
34MEIS1MEIS1
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)109410.031-0.3665No
35ZEB1110600.030-0.3707No
36TNFAIP6TNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 6111790.028-0.3749No
37MFAP3LMFAP3L
Entrez,  Source
microfibrillar-associated protein 3-like116990.022-0.3948No
38CADM1117210.022-0.3953No
39PRKAR2BPRKAR2B
Entrez,  Source
protein kinase, cAMP-dependent, regulatory, type II, beta122110.016-0.4141No
40DLC1DLC1
Entrez,  Source
deleted in liver cancer 1123460.014-0.4191No
41FAM70AFAM70A
Entrez,  Source
family with sequence similarity 70, member A124810.013-0.4241No
42ARHGAP5ARHGAP5
Entrez,  Source
Rho GTPase activating protein 5124930.012-0.4244No
43SOX4SOX4
Entrez,  Source
SRY (sex determining region Y)-box 4127740.009-0.4351No
44CFPCFP
Entrez,  Source
complement factor properdin128860.008-0.4393No
45DBN1DBN1
Entrez,  Source
drebrin 1133790.002-0.4584No
46GNAI1GNAI1
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 113626-0.001-0.4680No
47FERMT213782-0.003-0.4740No
48FAM125AFAM125A
Entrez,  Source
family with sequence similarity 125, member A13884-0.004-0.4778No
49NEXNNEXN
Entrez,  Source
nexilin (F actin binding protein)14171-0.007-0.4888No
50ATP10AATP10A
Entrez,  Source
ATPase, Class V, type 10A14188-0.008-0.4894No
51TMEM200A14618-0.014-0.5058No
52DMDDMD
Entrez,  Source
dystrophin (muscular dystrophy, Duchenne and Becker types)14802-0.017-0.5127No
53FLNBFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)14892-0.018-0.5159No
54TIMP3TIMP3
Entrez,  Source
TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)14947-0.019-0.5178No
55THBS1THBS1
Entrez,  Source
thrombospondin 114984-0.019-0.5189No
56GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)15050-0.020-0.5212No
57MACC115177-0.022-0.5258No
58TFDP2TFDP2
Entrez,  Source
transcription factor Dp-2 (E2F dimerization partner 2)15734-0.030-0.5470No
59ADRB1ADRB1
Entrez,  Source
adrenergic, beta-1-, receptor15874-0.032-0.5519No
60SLC5A3SLC5A3
Entrez,  Source
solute carrier family 5 (inositol transporters), member 315938-0.033-0.5539No
61TPSAB1TPSAB1
Entrez,  Source
tryptase alpha/beta 116115-0.035-0.5603No
62TPSB2TPSB2
Entrez,  Source
tryptase beta 216191-0.035-0.5627No
63MYCT1MYCT1
Entrez,  Source
myc target 116227-0.035-0.5636No
64IGLL1IGLL1
Entrez,  Source
immunoglobulin lambda-like polypeptide 116467-0.039-0.5724No
65KRT18KRT18
Entrez,  Source
keratin 1817123-0.050-0.5972No
66PTGS2PTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)17148-0.051-0.5974No
67ANGPT2ANGPT2
Entrez,  Source
angiopoietin 217302-0.055-0.6026No
68CFICFI
Entrez,  Source
complement factor I17374-0.056-0.6046No
69GEMGEM
Entrez,  Source
GTP binding protein overexpressed in skeletal muscle17376-0.056-0.6039No
70FAM55CFAM55C
Entrez,  Source
family with sequence similarity 55, member C17747-0.064-0.6174No
71BATF317811-0.065-0.6190No
72CAV1CAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa18061-0.072-0.6277No
73LGALS2LGALS2
Entrez,  Source
lectin, galactoside-binding, soluble, 2 (galectin 2)18342-0.080-0.6375No
74TM4SF1TM4SF1
Entrez,  Source
transmembrane 4 L six family member 118366-0.081-0.6373No
75HS3ST3B1HS3ST3B1
Entrez,  Source
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B118568-0.087-0.6439No
76OSBPL6OSBPL6
Entrez,  Source
oxysterol binding protein-like 618572-0.087-0.6429No
77ARG2ARG2
Entrez,  Source
arginase, type II18589-0.088-0.6423No
78HOXA5HOXA5
Entrez,  Source
homeobox A518787-0.093-0.6487No
79CCR6CCR6
Entrez,  Source
chemokine (C-C motif) receptor 618832-0.094-0.6491No
80RBPMSRBPMS
Entrez,  Source
RNA binding protein with multiple splicing19208-0.108-0.6623No
81CDC42EP3CDC42EP3
Entrez,  Source
CDC42 effector protein (Rho GTPase binding) 319328-0.113-0.6654No
82CDH1CDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)19483-0.119-0.6697No
83ITGB7ITGB7
Entrez,  Source
integrin, beta 719540-0.121-0.6703No
84KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog19570-0.122-0.6698No
85DUSP4DUSP4
Entrez,  Source
dual specificity phosphatase 419590-0.123-0.6689No
86TOXTOX
Entrez,  Source
-19609-0.124-0.6679No
87APOL6APOL6
Entrez,  Source
apolipoprotein L, 619838-0.133-0.6749No
88FBXL20FBXL20
Entrez,  Source
F-box and leucine-rich repeat protein 2019854-0.134-0.6737No
89PALLDPALLD
Entrez,  Source
palladin, cytoskeletal associated protein20036-0.141-0.6789No
90FGF18FGF18
Entrez,  Source
fibroblast growth factor 1820155-0.147-0.6815No
91TRIM9TRIM9
Entrez,  Source
tripartite motif-containing 920192-0.149-0.6809No
92HOXA3HOXA3
Entrez,  Source
homeobox A320206-0.150-0.6793No
93NR4A2NR4A2
Entrez,  Source
nuclear receptor subfamily 4, group A, member 220484-0.161-0.6879No
94IDO120686-0.171-0.6934No
95HOXB3HOXB3
Entrez,  Source
homeobox B320838-0.179-0.6969No
96STXBP6STXBP6
Entrez,  Source
syntaxin binding protein 6 (amisyn)20976-0.186-0.6997No
97METTL7BMETTL7B
Entrez,  Source
methyltransferase like 7B21057-0.192-0.7002No
98NEGR1NEGR1
Entrez,  Source
neuronal growth regulator 121267-0.207-0.7056No
99CLNK21281-0.208-0.7033No
100AFF3AFF3
Entrez,  Source
AF4/FMR2 family, member 321395-0.215-0.7048No
101FN1FN1
Entrez,  Source
fibronectin 121545-0.227-0.7075No
102EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 221911-0.256-0.7183No
103GPR18GPR18
Entrez,  Source
G protein-coupled receptor 1822406-0.298-0.7334No
104GMPRGMPR
Entrez,  Source
guanosine monophosphate reductase22516-0.310-0.7335No
105IL15IL15
Entrez,  Source
interleukin 1522561-0.316-0.7309No
106ABLIM1ABLIM1
Entrez,  Source
actin binding LIM protein 122601-0.320-0.7282No
107LY6ELY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E22607-0.320-0.7240No
108SPINK2SPINK2
Entrez,  Source
serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)22694-0.330-0.7230No
109STAT1STAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa23259-0.399-0.7395Yes
110CMPK223278-0.403-0.7348Yes
111SLC6A13SLC6A13
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, GABA), member 1323455-0.427-0.7359Yes
112TDRD9TDRD9
Entrez,  Source
tudor domain containing 923469-0.429-0.7306Yes
113EPSTI1EPSTI1
Entrez,  Source
epithelial stromal interaction 1 (breast)23538-0.439-0.7273Yes
114TGM5TGM5
Entrez,  Source
transglutaminase 523714-0.469-0.7278Yes
115FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 323747-0.473-0.7227Yes
116IRX3IRX3
Entrez,  Source
iroquois homeobox protein 323885-0.500-0.7213Yes
117CXCL10CXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1023939-0.510-0.7165Yes
118RAB27BRAB27B
Entrez,  Source
RAB27B, member RAS oncogene family24018-0.525-0.7124Yes
119DDX58DDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5824122-0.545-0.7091Yes
120BTLABTLA
Entrez,  Source
B and T lymphocyte associated24158-0.555-0.7030Yes
121PLD4PLD4
Entrez,  Source
phospholipase D family, member 424223-0.572-0.6977Yes
122SLC8A1SLC8A1
Entrez,  Source
solute carrier family 8 (sodium/calcium exchanger), member 124281-0.583-0.6921Yes
123MCOLN2MCOLN2
Entrez,  Source
mucolipin 224305-0.589-0.6851Yes
124BEND624516-0.648-0.6845Yes
125ANGPT1ANGPT1
Entrez,  Source
angiopoietin 124667-0.694-0.6810Yes
126IFIT2IFIT2
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 224672-0.695-0.6718Yes
127DEFB1DEFB1
Entrez,  Source
defensin, beta 124830-0.746-0.6679Yes
128CD38CD38
Entrez,  Source
CD38 molecule24844-0.751-0.6582Yes
129LSP1LSP1
Entrez,  Source
lymphocyte-specific protein 124855-0.756-0.6485Yes
130DHRS3DHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 325082-0.863-0.6456Yes
131PCDH20PCDH20
Entrez,  Source
protocadherin 2025092-0.866-0.6343Yes
132ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A125098-0.871-0.6228Yes
133ADSSL1ADSSL1
Entrez,  Source
adenylosuccinate synthase like 125110-0.875-0.6114Yes
134SCN4BSCN4B
Entrez,  Source
sodium channel, voltage-gated, type IV, beta25178-0.912-0.6017Yes
135MX2MX2
Entrez,  Source
myxovirus (influenza virus) resistance 2 (mouse)25230-0.948-0.5910Yes
136SPOCK1SPOCK1
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 125311-1.016-0.5804Yes
137CALB1CALB1
Entrez,  Source
calbindin 1, 28kDa25355-1.050-0.5679Yes
138FAM134B25364-1.056-0.5540Yes
139OLFM3OLFM3
Entrez,  Source
olfactomedin 325414-1.111-0.5410Yes
140IGJIGJ
Entrez,  Source
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides25425-1.119-0.5263Yes
141MX1MX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)25437-1.129-0.5115Yes
142OAS2OAS2
Entrez,  Source
2'-5'-oligoadenylate synthetase 2, 69/71kDa25558-1.284-0.4989Yes
143TMEM45ATMEM45A
Entrez,  Source
transmembrane protein 45A25606-1.358-0.4824Yes
144DNAJC6DNAJC6
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 625653-1.446-0.4648Yes
145ISG15ISG15
Entrez,  Source
ISG15 ubiquitin-like modifier25699-1.594-0.4451Yes
146DDX6025710-1.643-0.4233Yes
147LGALS3BPLGALS3BP
Entrez,  Source
lectin, galactoside-binding, soluble, 3 binding protein25761-1.839-0.4005Yes
148ADCYAP1ADCYAP1
Entrez,  Source
adenylate cyclase activating polypeptide 1 (pituitary)25766-1.848-0.3758Yes
149IRF7IRF7
Entrez,  Source
interferon regulatory factor 725794-2.009-0.3498Yes
150RSAD2RSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 225795-2.013-0.3227Yes
151IFIH1IFIH1
Entrez,  Source
interferon induced with helicase C domain 125804-2.052-0.2954Yes
152XAF125822-2.156-0.2670Yes
153USP18USP18
Entrez,  Source
ubiquitin specific peptidase 1825830-2.231-0.2373Yes
154IFI44IFI44
Entrez,  Source
interferon-induced protein 4425831-2.278-0.2066Yes
155RTP4RTP4
Entrez,  Source
receptor transporter protein 425833-2.300-0.1757Yes
156IFIT3IFIT3
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 325844-2.414-0.1436Yes
157SAMD9LSAMD9L
Entrez,  Source
sterile alpha motif domain containing 9-like25888-3.178-0.1025Yes
158SLITRK4SLITRK4
Entrez,  Source
SLIT and NTRK-like family, member 425892-3.562-0.0546Yes
159IFIT1IFIT1
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 125894-4.0730.0002Yes
Table: GSEA details [plain text format]



Fig 2: TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP: Random ES distribution   
Gene set null distribution of ES for TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP