Details for gene set ZHANG_TLX_TARGETS_60HR_DN[GSEA]

Table: GSEA Results Summary

Dataset	SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos
Phenotype	SMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class	0
GeneSet	ZHANG_TLX_TARGETS_60HR_DN
Enrichment Score (ES)	0.46967688
Normalized Enrichment Score (NES)	1.9857862
Nominal p-value	0.0
FDR q-value	0.18165211
FWER p-Value	0.444

Fig 1: Enrichment plot: ZHANG_TLX_TARGETS_60HR_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	LIPT2			326	0.511	0.0148	Yes
2	GSG2	GSG2 Entrez,  Source	germ cell associated 2 (haspin)	459	0.442	0.0334	Yes
3	GJC1	GJC1 Entrez,  Source	gap junction protein, chi 1, 31.9kDa (connexin 31.9)	617	0.389	0.0482	Yes
4	ASF1B	ASF1B Entrez,  Source	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	1459	0.234	0.0280	Yes
5	LAMP3	LAMP3 Entrez,  Source	lysosomal-associated membrane protein 3	1475	0.233	0.0399	Yes
6	LRR1			1534	0.225	0.0497	Yes
7	CENPK	CENPK Entrez,  Source	centromere protein K	1652	0.210	0.0565	Yes
8	GINS1	GINS1 Entrez,  Source	GINS complex subunit 1 (Psf1 homolog)	1800	0.195	0.0612	Yes
9	CCDC99	CCDC99 Entrez,  Source	coiled-coil domain containing 99	2125	0.165	0.0574	Yes
10	SKP2	SKP2 Entrez,  Source	S-phase kinase-associated protein 2 (p45)	2349	0.163	0.0575	Yes
11	SGOL1	SGOL1 Entrez,  Source	shugoshin-like 1 (S. pombe)	2403	0.160	0.0640	Yes
12	ETAA1	ETAA1 Entrez,  Source	Ewing's tumor-associated antigen 1	2481	0.152	0.0692	Yes
13	FAM111A	FAM111A Entrez,  Source	family with sequence similarity 111, member A	2484	0.152	0.0773	Yes
14	ERCC6L			2491	0.151	0.0852	Yes
15	TYMS	TYMS Entrez,  Source	thymidylate synthetase	2505	0.150	0.0928	Yes
16	RAD51AP1	RAD51AP1 Entrez,  Source	RAD51 associated protein 1	2626	0.146	0.0960	Yes
17	POLE2	POLE2 Entrez,  Source	polymerase (DNA directed), epsilon 2 (p59 subunit)	2630	0.146	0.1037	Yes
18	SASS6	SASS6 Entrez,  Source	spindle assembly 6 homolog (C. elegans)	2674	0.143	0.1098	Yes
19	TRIP13	TRIP13 Entrez,  Source	thyroid hormone receptor interactor 13	2702	0.141	0.1163	Yes
20	CD93	CD93 Entrez,  Source	CD93 molecule	2706	0.141	0.1238	Yes
21	DACT1	DACT1 Entrez,  Source	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	2747	0.137	0.1296	Yes
22	DDX20	DDX20 Entrez,  Source	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	2836	0.133	0.1333	Yes
23	EME1	EME1 Entrez,  Source	essential meiotic endonuclease 1 homolog 1 (S. pombe)	2841	0.132	0.1403	Yes
24	SYCE2	SYCE2 Entrez,  Source	synaptonemal complex central element protein 2	2860	0.131	0.1466	Yes
25	CDCA5	CDCA5 Entrez,  Source	cell division cycle associated 5	2865	0.130	0.1535	Yes
26	CHEK1	CHEK1 Entrez,  Source	CHK1 checkpoint homolog (S. pombe)	2928	0.126	0.1579	Yes
27	FIGNL1	FIGNL1 Entrez,  Source	fidgetin-like 1	2930	0.126	0.1646	Yes
28	CHAF1B	CHAF1B Entrez,  Source	chromatin assembly factor 1, subunit B (p60)	2971	0.124	0.1697	Yes
29	CDCA7	CDCA7 Entrez,  Source	cell division cycle associated 7	2983	0.123	0.1759	Yes
30	POLA1	POLA1 Entrez,  Source	polymerase (DNA directed), alpha 1	2993	0.123	0.1821	Yes
31	TTK	TTK Entrez,  Source	TTK protein kinase	3042	0.119	0.1867	Yes
32	MMS22L			3118	0.115	0.1899	Yes
33	STC2	STC2 Entrez,  Source	stanniocalcin 2	3120	0.114	0.1960	Yes
34	DHFR	DHFR Entrez,  Source	dihydrofolate reductase	3124	0.114	0.2020	Yes
35	TIPIN	TIPIN Entrez,  Source	TIMELESS interacting protein	3139	0.114	0.2076	Yes
36	POLR3K	POLR3K Entrez,  Source	polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa	3162	0.112	0.2128	Yes
37	SKA1			3180	0.111	0.2181	Yes
38	SHCBP1	SHCBP1 Entrez,  Source	SHC SH2-domain binding protein 1	3202	0.110	0.2232	Yes
39	NUP107	NUP107 Entrez,  Source	nucleoporin 107kDa	3247	0.108	0.2273	Yes
40	PLK4	PLK4 Entrez,  Source	polo-like kinase 4 (Drosophila)	3251	0.108	0.2330	Yes
41	BUB1	BUB1 Entrez,  Source	BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)	3261	0.107	0.2384	Yes
42	PRIM1	PRIM1 Entrez,  Source	primase, polypeptide 1, 49kDa	3268	0.107	0.2439	Yes
43	CDC6	CDC6 Entrez,  Source	CDC6 cell division cycle 6 homolog (S. cerevisiae)	3285	0.106	0.2490	Yes
44	RFC4	RFC4 Entrez,  Source	replication factor C (activator 1) 4, 37kDa	3299	0.105	0.2542	Yes
45	WDR90	WDR90 Entrez,  Source	WD repeat domain 90	3339	0.103	0.2582	Yes
46	CASP8AP2	CASP8AP2 Entrez,  Source	CASP8 associated protein 2	3342	0.103	0.2637	Yes
47	CDC45			3350	0.103	0.2689	Yes
48	TIMELESS	TIMELESS Entrez,  Source	timeless homolog (Drosophila)	3361	0.102	0.2740	Yes
49	GMNN	GMNN Entrez,  Source	geminin, DNA replication inhibitor	3370	0.102	0.2792	Yes
50	CENPH	CENPH Entrez,  Source	centromere protein H	3389	0.102	0.2840	Yes
51	BEX1	BEX1 Entrez,  Source	brain expressed, X-linked 1	3408	0.100	0.2887	Yes
52	HAUS6			3501	0.097	0.2903	Yes
53	MCM10	MCM10 Entrez,  Source	MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)	3508	0.097	0.2953	Yes
54	CEP55	CEP55 Entrez,  Source	centrosomal protein 55kDa	3514	0.097	0.3003	Yes
55	EXOSC2	EXOSC2 Entrez,  Source	exosome component 2	3530	0.096	0.3049	Yes
56	PKDCC			3545	0.095	0.3094	Yes
57	RAD18	RAD18 Entrez,  Source	RAD18 homolog (S. cerevisiae)	3577	0.094	0.3133	Yes
58	BLM	BLM Entrez,  Source	Bloom syndrome	3626	0.092	0.3163	Yes
59	VRK1	VRK1 Entrez,  Source	vaccinia related kinase 1	3639	0.091	0.3208	Yes
60	NCAPG	NCAPG Entrez,  Source	non-SMC condensin I complex, subunit G	3663	0.090	0.3248	Yes
61	BIRC5	BIRC5 Entrez,  Source	baculoviral IAP repeat-containing 5 (survivin)	3691	0.090	0.3285	Yes
62	DTL	DTL Entrez,  Source	denticleless homolog (Drosophila)	3696	0.089	0.3332	Yes
63	SMC4	SMC4 Entrez,  Source	structural maintenance of chromosomes 4	3717	0.088	0.3371	Yes
64	PPAT	PPAT Entrez,  Source	phosphoribosyl pyrophosphate amidotransferase	3759	0.087	0.3402	Yes
65	UCHL5	UCHL5 Entrez,  Source	ubiquitin carboxyl-terminal hydrolase L5	3781	0.086	0.3440	Yes
66	USP1	USP1 Entrez,  Source	ubiquitin specific peptidase 1	3988	0.086	0.3406	Yes
67	CENPN	CENPN Entrez,  Source	centromere protein N	4004	0.085	0.3446	Yes
68	NT5DC2	NT5DC2 Entrez,  Source	5'-nucleotidase domain containing 2	4020	0.085	0.3486	Yes
69	FAM64A	FAM64A Entrez,  Source	family with sequence similarity 64, member A	4062	0.083	0.3515	Yes
70	PRIM2			4066	0.083	0.3559	Yes
71	EXO1	EXO1 Entrez,  Source	exonuclease 1	4079	0.083	0.3598	Yes
72	DUT	DUT Entrez,  Source	dUTP pyrophosphatase	4087	0.082	0.3640	Yes
73	SHMT2	SHMT2 Entrez,  Source	serine hydroxymethyltransferase 2 (mitochondrial)	4093	0.082	0.3682	Yes
74	MRPL50	MRPL50 Entrez,  Source	mitochondrial ribosomal protein L50	4130	0.081	0.3712	Yes
75	ORC2			4143	0.080	0.3750	Yes
76	NCAPG2	NCAPG2 Entrez,  Source	non-SMC condensin II complex, subunit G2	4155	0.080	0.3789	Yes
77	ZMYND19	ZMYND19 Entrez,  Source	zinc finger, MYND-type containing 19	4209	0.078	0.3810	Yes
78	MASTL	MASTL Entrez,  Source	microtubule associated serine/threonine kinase-like	4210	0.078	0.3852	Yes
79	SMC6	SMC6 Entrez,  Source	structural maintenance of chromosomes 6	4260	0.077	0.3874	Yes
80	KIF2C	KIF2C Entrez,  Source	kinesin family member 2C	4267	0.076	0.3913	Yes
81	MCM6	MCM6 Entrez,  Source	MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	4276	0.076	0.3951	Yes
82	NUCKS1	NUCKS1 Entrez,  Source	nuclear casein kinase and cyclin-dependent kinase substrate 1	4278	0.076	0.3991	Yes
83	HAT1	HAT1 Entrez,  Source	histone acetyltransferase 1	4293	0.075	0.4026	Yes
84	RAD51	RAD51 Entrez,  Source	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	4332	0.074	0.4052	Yes
85	DCTPP1			4335	0.074	0.4091	Yes
86	ANLN	ANLN Entrez,  Source	anillin, actin binding protein	7973	0.074	0.2712	Yes
87	SRSF1			7992	0.073	0.2744	Yes
88	CCNA2	CCNA2 Entrez,  Source	cyclin A2	7999	0.073	0.2781	Yes
89	E2F8	E2F8 Entrez,  Source	E2F transcription factor 8	8004	0.073	0.2819	Yes
90	CDC25A	CDC25A Entrez,  Source	cell division cycle 25A	8040	0.072	0.2844	Yes
91	LYAR	LYAR Entrez,  Source	-	8134	0.072	0.2846	Yes
92	RBBP8	RBBP8 Entrez,  Source	retinoblastoma binding protein 8	8178	0.071	0.2867	Yes
93	TMPO	TMPO Entrez,  Source	thymopoietin	8207	0.070	0.2894	Yes
94	UHRF1	UHRF1 Entrez,  Source	ubiquitin-like, containing PHD and RING finger domains, 1	8213	0.070	0.2930	Yes
95	RBL1	RBL1 Entrez,  Source	retinoblastoma-like 1 (p107)	8225	0.070	0.2963	Yes
96	MELK	MELK Entrez,  Source	maternal embryonic leucine zipper kinase	8236	0.069	0.2996	Yes
97	LSM2	LSM2 Entrez,  Source	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	8239	0.069	0.3033	Yes
98	ECT2	ECT2 Entrez,  Source	epithelial cell transforming sequence 2 oncogene	8270	0.069	0.3058	Yes
99	LARP7	LARP7 Entrez,  Source	La ribonucleoprotein domain family, member 7	8338	0.068	0.3068	Yes
100	SMC2	SMC2 Entrez,  Source	structural maintenance of chromosomes 2	8352	0.067	0.3099	Yes
101	RIF1	RIF1 Entrez,  Source	RAP1 interacting factor homolog (yeast)	8355	0.067	0.3135	Yes
102	ERI1			8452	0.065	0.3132	Yes
103	FBLN2	FBLN2 Entrez,  Source	fibulin 2	8467	0.065	0.3162	Yes
104	TOPBP1	TOPBP1 Entrez,  Source	topoisomerase (DNA) II binding protein 1	8478	0.065	0.3192	Yes
105	ZWILCH	ZWILCH Entrez,  Source	Zwilch, kinetochore associated, homolog (Drosophila)	8495	0.064	0.3221	Yes
106	UCK2	UCK2 Entrez,  Source	uridine-cytidine kinase 2	8505	0.064	0.3252	Yes
107	BRCA1	BRCA1 Entrez,  Source	breast cancer 1, early onset	8541	0.063	0.3272	Yes
108	KIF22	KIF22 Entrez,  Source	kinesin family member 22	8553	0.063	0.3302	Yes
109	DBF4	DBF4 Entrez,  Source	DBF4 homolog (S. cerevisiae)	8568	0.063	0.3330	Yes
110	DNAJC2			8580	0.062	0.3359	Yes
111	MCM4	MCM4 Entrez,  Source	MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)	8582	0.062	0.3392	Yes
112	ANP32E	ANP32E Entrez,  Source	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	8593	0.062	0.3421	Yes
113	PBK	PBK Entrez,  Source	PDZ binding kinase	8608	0.062	0.3449	Yes
114	EZH2	EZH2 Entrez,  Source	enhancer of zeste homolog 2 (Drosophila)	8626	0.061	0.3475	Yes
115	ELOVL2	ELOVL2 Entrez,  Source	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	8638	0.061	0.3504	Yes
116	RPA2	RPA2 Entrez,  Source	replication protein A2, 32kDa	8646	0.061	0.3534	Yes
117	WDHD1	WDHD1 Entrez,  Source	WD repeat and HMG-box DNA binding protein 1	8662	0.061	0.3561	Yes
118	PLK1	PLK1 Entrez,  Source	polo-like kinase 1 (Drosophila)	8688	0.060	0.3584	Yes
119	TARDBP	TARDBP Entrez,  Source	TAR DNA binding protein	8912	0.060	0.3529	Yes
120	LIG1	LIG1 Entrez,  Source	ligase I, DNA, ATP-dependent	8928	0.059	0.3555	Yes
121	LMNB1	LMNB1 Entrez,  Source	lamin B1	8951	0.059	0.3578	Yes
122	SLC12A2	SLC12A2 Entrez,  Source	solute carrier family 12 (sodium/potassium/chloride transporters), member 2	8967	0.059	0.3604	Yes
123	MCM5	MCM5 Entrez,  Source	MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	9075	0.057	0.3593	Yes
124	DCK	DCK Entrez,  Source	deoxycytidine kinase	9076	0.057	0.3623	Yes
125	CASQ1	CASQ1 Entrez,  Source	calsequestrin 1 (fast-twitch, skeletal muscle)	9098	0.057	0.3645	Yes
126	RRM1	RRM1 Entrez,  Source	ribonucleotide reductase M1 polypeptide	9137	0.056	0.3661	Yes
127	AK4			9167	0.055	0.3679	Yes
128	HMMR	HMMR Entrez,  Source	hyaluronan-mediated motility receptor (RHAMM)	9173	0.055	0.3707	Yes
129	POLE	POLE Entrez,  Source	polymerase (DNA directed), epsilon	9191	0.055	0.3729	Yes
130	TACC3	TACC3 Entrez,  Source	transforming, acidic coiled-coil containing protein 3	9196	0.055	0.3757	Yes
131	LTV1	LTV1 Entrez,  Source	LTV1 homolog (S. cerevisiae)	9252	0.055	0.3765	Yes
132	RACGAP1	RACGAP1 Entrez,  Source	Rac GTPase activating protein 1	9253	0.055	0.3795	Yes
133	TOP2A	TOP2A Entrez,  Source	topoisomerase (DNA) II alpha 170kDa	9270	0.054	0.3818	Yes
134	UTP6	UTP6 Entrez,  Source	UTP6, small subunit (SSU) processome component, homolog (yeast)	9326	0.053	0.3825	Yes
135	DDX21	DDX21 Entrez,  Source	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	9336	0.053	0.3850	Yes
136	IVNS1ABP	IVNS1ABP Entrez,  Source	influenza virus NS1A binding protein	9362	0.052	0.3868	Yes
137	NUP160	NUP160 Entrez,  Source	nucleoporin 160kDa	9370	0.052	0.3893	Yes
138	FAM54A	FAM54A Entrez,  Source	family with sequence similarity 54, member A	9387	0.052	0.3915	Yes
139	ZBTB12	ZBTB12 Entrez,  Source	zinc finger and BTB domain containing 12	9424	0.052	0.3929	Yes
140	DBT	DBT Entrez,  Source	dihydrolipoamide branched chain transacylase E2	9425	0.052	0.3957	Yes
141	CCNB2	CCNB2 Entrez,  Source	cyclin B2	9453	0.051	0.3974	Yes
142	NUP85	NUP85 Entrez,  Source	nucleoporin 85kDa	9467	0.051	0.3996	Yes
143	WDR43	WDR43 Entrez,  Source	WD repeat domain 43	9517	0.050	0.4004	Yes
144	NAP1L1	NAP1L1 Entrez,  Source	nucleosome assembly protein 1-like 1	9554	0.050	0.4017	Yes
145	DCPS	DCPS Entrez,  Source	decapping enzyme, scavenger	9566	0.049	0.4039	Yes
146	LMNB2	LMNB2 Entrez,  Source	lamin B2	9568	0.049	0.4065	Yes
147	MCM3	MCM3 Entrez,  Source	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	9611	0.049	0.4075	Yes
148	KIF11	KIF11 Entrez,  Source	kinesin family member 11	9652	0.048	0.4085	Yes
149	POLD2	POLD2 Entrez,  Source	polymerase (DNA directed), delta 2, regulatory subunit 50kDa	9681	0.048	0.4100	Yes
150	SRSF3			9702	0.047	0.4118	Yes
151	AURKB	AURKB Entrez,  Source	aurora kinase B	9747	0.047	0.4126	Yes
152	NASP	NASP Entrez,  Source	nuclear autoantigenic sperm protein (histone-binding)	9757	0.047	0.4148	Yes
153	SRSF7			9761	0.047	0.4172	Yes
154	SDF2L1	SDF2L1 Entrez,  Source	stromal cell-derived factor 2-like 1	9800	0.046	0.4181	Yes
155	RDX	RDX Entrez,  Source	radixin	9856	0.046	0.4185	Yes
156	PARP1	PARP1 Entrez,  Source	poly (ADP-ribose) polymerase family, member 1	9902	0.045	0.4191	Yes
157	NUF2			9919	0.045	0.4209	Yes
158	FANCI	FANCI Entrez,  Source	Fanconi anemia, complementation group I	9924	0.045	0.4232	Yes
159	HMGXB4			9941	0.044	0.4249	Yes
160	DEK	DEK Entrez,  Source	DEK oncogene (DNA binding)	9948	0.044	0.4271	Yes
161	POLA2	POLA2 Entrez,  Source	polymerase (DNA directed), alpha 2 (70kD subunit)	9968	0.044	0.4287	Yes
162	MCM7	MCM7 Entrez,  Source	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	9993	0.044	0.4301	Yes
163	VARS	VARS Entrez,  Source	valyl-tRNA synthetase	10057	0.043	0.4300	Yes
164	UBR7			10059	0.043	0.4322	Yes
165	RFC1	RFC1 Entrez,  Source	replication factor C (activator 1) 1, 145kDa	10084	0.042	0.4336	Yes
166	POLD1	POLD1 Entrez,  Source	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	10086	0.042	0.4358	Yes
167	HMGB2	HMGB2 Entrez,  Source	high-mobility group box 2	10107	0.042	0.4373	Yes
168	ORC1			10108	0.042	0.4395	Yes
169	SYNCRIP	SYNCRIP Entrez,  Source	synaptotagmin binding, cytoplasmic RNA interacting protein	10152	0.041	0.4401	Yes
170	CBX5	CBX5 Entrez,  Source	chromobox homolog 5 (HP1 alpha homolog, Drosophila)	10161	0.041	0.4420	Yes
171	PRPS1	PRPS1 Entrez,  Source	phosphoribosyl pyrophosphate synthetase 1	10197	0.041	0.4428	Yes
172	HSPA4	HSPA4 Entrez,  Source	heat shock 70kDa protein 4	10209	0.041	0.4446	Yes
173	DLG4	DLG4 Entrez,  Source	discs, large homolog 4 (Drosophila)	10224	0.040	0.4462	Yes
174	EPRS	EPRS Entrez,  Source	glutamyl-prolyl-tRNA synthetase	10249	0.040	0.4474	Yes
175	WDR46	WDR46 Entrez,  Source	WD repeat domain 46	10293	0.040	0.4479	Yes
176	INCENP	INCENP Entrez,  Source	inner centromere protein antigens 135/155kDa	10322	0.039	0.4489	Yes
177	MYBL2	MYBL2 Entrez,  Source	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	10368	0.039	0.4492	Yes
178	NUP155	NUP155 Entrez,  Source	nucleoporin 155kDa	10377	0.038	0.4510	Yes
179	MSH6	MSH6 Entrez,  Source	mutS homolog 6 (E. coli)	10395	0.038	0.4523	Yes
180	ASCL1	ASCL1 Entrez,  Source	achaete-scute complex-like 1 (Drosophila)	10402	0.038	0.4541	Yes
181	TMEM48	TMEM48 Entrez,  Source	transmembrane protein 48	10414	0.038	0.4557	Yes
182	BUB1B	BUB1B Entrez,  Source	BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)	10437	0.037	0.4569	Yes
183	NSUN2	NSUN2 Entrez,  Source	NOL1/NOP2/Sun domain family, member 2	10441	0.037	0.4588	Yes
184	NUP43	NUP43 Entrez,  Source	nucleoporin 43kDa	10445	0.037	0.4607	Yes
185	RFC5	RFC5 Entrez,  Source	replication factor C (activator 1) 5, 36.5kDa	10501	0.037	0.4605	Yes
186	SETDB1	SETDB1 Entrez,  Source	SET domain, bifurcated 1	10516	0.036	0.4619	Yes
187	SRM	SRM Entrez,  Source	spermidine synthase	10574	0.036	0.4616	Yes
188	SKIV2L2	SKIV2L2 Entrez,  Source	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	10618	0.035	0.4618	Yes
189	GLUL	GLUL Entrez,  Source	glutamate-ammonia ligase (glutamine synthetase)	10645	0.035	0.4627	Yes
190	HNRNPR			10658	0.035	0.4641	Yes
191	TIPARP	TIPARP Entrez,  Source	TCDD-inducible poly(ADP-ribose) polymerase	10666	0.034	0.4656	Yes
192	MCM2	MCM2 Entrez,  Source	MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)	10680	0.034	0.4670	Yes
193	IL4I1	IL4I1 Entrez,  Source	interleukin 4 induced 1	10713	0.034	0.4676	Yes
194	DNA2			10747	0.033	0.4681	Yes
195	NCAPD2	NCAPD2 Entrez,  Source	non-SMC condensin I complex, subunit D2	10892	0.032	0.4642	Yes
196	INTS7	INTS7 Entrez,  Source	integrator complex subunit 7	10895	0.032	0.4658	Yes
197	HUS1	HUS1 Entrez,  Source	HUS1 checkpoint homolog (S. pombe)	10921	0.031	0.4665	Yes
198	DNAJC21			10940	0.031	0.4674	Yes
199	CDV3	CDV3 Entrez,  Source	CDV3 homolog (mouse)	10993	0.030	0.4671	Yes
200	FKBP5	FKBP5 Entrez,  Source	FK506 binding protein 5	11027	0.030	0.4674	Yes
201	RFC3	RFC3 Entrez,  Source	replication factor C (activator 1) 3, 38kDa	11033	0.030	0.4688	Yes
202	NOLC1	NOLC1 Entrez,  Source	nucleolar and coiled-body phosphoprotein 1	11053	0.030	0.4697	Yes
203	DHX36	DHX36 Entrez,  Source	DEAH (Asp-Glu-Ala-His) box polypeptide 36	11146	0.029	0.4676	No
204	DNMT1	DNMT1 Entrez,  Source	DNA (cytosine-5-)-methyltransferase 1	11167	0.029	0.4684	No
205	RRM2	RRM2 Entrez,  Source	ribonucleotide reductase M2 polypeptide	11196	0.028	0.4688	No
206	MRE11A	MRE11A Entrez,  Source	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	11214	0.028	0.4697	No
207	HJURP			11262	0.027	0.4693	No
208	WDR77	WDR77 Entrez,  Source	WD repeat domain 77	11355	0.026	0.4671	No
209	EIF2S1	EIF2S1 Entrez,  Source	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	11375	0.026	0.4678	No
210	DIS3			11406	0.026	0.4680	No
211	UNG	UNG Entrez,  Source	uracil-DNA glycosylase	11514	0.024	0.4652	No
212	WDR33	WDR33 Entrez,  Source	WD repeat domain 33	11600	0.024	0.4631	No
213	GART	GART Entrez,  Source	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	11889	0.020	0.4529	No
214	TK1	TK1 Entrez,  Source	thymidine kinase 1, soluble	11893	0.020	0.4539	No
215	EIF4E	EIF4E Entrez,  Source	eukaryotic translation initiation factor 4E	12026	0.018	0.4497	No
216	HSP90B1	HSP90B1 Entrez,  Source	heat shock protein 90kDa beta (Grp94), member 1	12126	0.017	0.4468	No
217	CENPM	CENPM Entrez,  Source	centromere protein M	12220	0.016	0.4440	No
218	EIF4G1	EIF4G1 Entrez,  Source	eukaryotic translation initiation factor 4 gamma, 1	12263	0.016	0.4432	No
219	HYOU1	HYOU1 Entrez,  Source	hypoxia up-regulated 1	12328	0.015	0.4415	No
220	ERO1L	ERO1L Entrez,  Source	ERO1-like (S. cerevisiae)	12368	0.014	0.4408	No
221	SHMT1	SHMT1 Entrez,  Source	serine hydroxymethyltransferase 1 (soluble)	12642	0.011	0.4307	No
222	FEN1	FEN1 Entrez,  Source	flap structure-specific endonuclease 1	12646	0.011	0.4312	No
223	HK2	HK2 Entrez,  Source	hexokinase 2	12757	0.010	0.4274	No
224	DHODH	DHODH Entrez,  Source	dihydroorotate dehydrogenase	13199	0.004	0.4104	No
225	PDZD11	PDZD11 Entrez,  Source	PDZ domain containing 11	13237	0.004	0.4092	No
226	UMPS	UMPS Entrez,  Source	uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)	13285	0.003	0.4075	No
227	TNRC6A	TNRC6A Entrez,  Source	trinucleotide repeat containing 6A	13377	0.002	0.4041	No
228	CENPF	CENPF Entrez,  Source	centromere protein F, 350/400ka (mitosin)	13466	0.001	0.4007	No
229	SPAG5	SPAG5 Entrez,  Source	sperm associated antigen 5	13814	-0.003	0.3873	No
230	IFRD2	IFRD2 Entrez,  Source	interferon-related developmental regulator 2	13959	-0.005	0.3820	No
231	ME2	ME2 Entrez,  Source	malic enzyme 2, NAD(+)-dependent, mitochondrial	13965	-0.005	0.3820	No
232	SMARCA4	SMARCA4 Entrez,  Source	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	14130	-0.007	0.3760	No
233	CDT1	CDT1 Entrez,  Source	chromatin licensing and DNA replication factor 1	14143	-0.007	0.3759	No
234	CDCA7L	CDCA7L Entrez,  Source	cell division cycle associated 7-like	14347	-0.010	0.3685	No
235	RBM14	RBM14 Entrez,  Source	RNA binding motif protein 14	14547	-0.013	0.3614	No
236	SON	SON Entrez,  Source	SON DNA binding protein	14648	-0.014	0.3583	No
237	RAD54L	RAD54L Entrez,  Source	RAD54-like (S. cerevisiae)	14784	-0.016	0.3539	No
238	TBL2	TBL2 Entrez,  Source	transducin (beta)-like 2	14831	-0.017	0.3530	No
239	AATF	AATF Entrez,  Source	apoptosis antagonizing transcription factor	14954	-0.019	0.3493	No
240	THRAP3	THRAP3 Entrez,  Source	thyroid hormone receptor associated protein 3	15111	-0.021	0.3443	No
241	RAD51C	RAD51C Entrez,  Source	RAD51 homolog C (S. cerevisiae)	15118	-0.021	0.3452	No
242	MKI67	MKI67 Entrez,  Source	antigen identified by monoclonal antibody Ki-67	15149	-0.022	0.3452	No
243	GRWD1	GRWD1 Entrez,  Source	glutamate-rich WD repeat containing 1	15161	-0.022	0.3460	No
244	HMGB1	HMGB1 Entrez,  Source	high-mobility group box 1	15266	-0.024	0.3432	No
245	FANCA	FANCA Entrez,  Source	Fanconi anemia, complementation group A	15269	-0.024	0.3444	No
246	PEG3	PEG3 Entrez,  Source	paternally expressed 3	15338	-0.024	0.3430	No
247	RRP12			15341	-0.024	0.3442	No
248	DIMT1			15449	-0.025	0.3414	No
249	WEE1	WEE1 Entrez,  Source	WEE1 homolog (S. pombe)	15707	-0.029	0.3330	No
250	TIMM9	TIMM9 Entrez,  Source	translocase of inner mitochondrial membrane 9 homolog (yeast)	15733	-0.030	0.3336	No
251	MYO10	MYO10 Entrez,  Source	myosin X	16053	-0.035	0.3230	No
252	FRMD4B	FRMD4B Entrez,  Source	FERM domain containing 4B	16439	-0.038	0.3101	No
253	NTN1	NTN1 Entrez,  Source	netrin 1	16491	-0.039	0.3102	No
254	TCF19	TCF19 Entrez,  Source	transcription factor 19 (SC1)	16559	-0.040	0.3097	No
255	SLC2A3	SLC2A3 Entrez,  Source	solute carrier family 2 (facilitated glucose transporter), member 3	17335	-0.055	0.2824	No
256	PPP1R18			17574	-0.060	0.2764	No
257	ATM	ATM Entrez,  Source	ataxia telangiectasia mutated (includes complementation groups A, C and D)	17577	-0.060	0.2796	No
258	SOAT1	SOAT1 Entrez,  Source	sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1	17645	-0.062	0.2803	No
259	NET1	NET1 Entrez,  Source	neuroepithelial cell transforming gene 1	17779	-0.065	0.2786	No
260	NRARP			17858	-0.067	0.2791	No
261	SLC4A4	SLC4A4 Entrez,  Source	solute carrier family 4, sodium bicarbonate cotransporter, member 4	18269	-0.078	0.2673	No
262	CCNE1	CCNE1 Entrez,  Source	cyclin E1	18646	-0.089	0.2574	No
263	AMD1	AMD1 Entrez,  Source	adenosylmethionine decarboxylase 1	18703	-0.091	0.2601	No
264	PDZRN3	PDZRN3 Entrez,  Source	PDZ domain containing RING finger 3	20701	-0.172	0.1914	No
265	TTPA	TTPA Entrez,  Source	tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)	21296	-0.209	0.1795	No

Fig 2: ZHANG_TLX_TARGETS_60HR_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: ZHANG_TLX_TARGETS_60HR_DN: Random ES distribution   
Gene set null distribution of ES for ZHANG_TLX_TARGETS_60HR_DN