Details for gene set ZHANG_TLX_TARGETS_DN[GSEA]

Table: GSEA Results Summary

Dataset	SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos
Phenotype	SMCHD1_KO.cls#del_versus_fl_repos
Upregulated in class	0
GeneSet	ZHANG_TLX_TARGETS_DN
Enrichment Score (ES)	0.51898986
Normalized Enrichment Score (NES)	2.072519
Nominal p-value	0.0
FDR q-value	0.22078115
FWER p-Value	0.161

Fig 1: Enrichment plot: ZHANG_TLX_TARGETS_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	LRR1			1534	0.225	-0.0284	Yes
2	CENPK	CENPK Entrez,  Source	centromere protein K	1652	0.210	-0.0041	Yes
3	GINS1	GINS1 Entrez,  Source	GINS complex subunit 1 (Psf1 homolog)	1800	0.195	0.0170	Yes
4	CCDC99	CCDC99 Entrez,  Source	coiled-coil domain containing 99	2125	0.165	0.0271	Yes
5	SGOL1	SGOL1 Entrez,  Source	shugoshin-like 1 (S. pombe)	2403	0.160	0.0384	Yes
6	FAM111A	FAM111A Entrez,  Source	family with sequence similarity 111, member A	2484	0.152	0.0562	Yes
7	ERCC6L			2491	0.151	0.0768	Yes
8	TYMS	TYMS Entrez,  Source	thymidylate synthetase	2505	0.150	0.0970	Yes
9	RAD51AP1	RAD51AP1 Entrez,  Source	RAD51 associated protein 1	2626	0.146	0.1125	Yes
10	SASS6	SASS6 Entrez,  Source	spindle assembly 6 homolog (C. elegans)	2674	0.143	0.1303	Yes
11	TRIP13	TRIP13 Entrez,  Source	thyroid hormone receptor interactor 13	2702	0.141	0.1487	Yes
12	CHEK1	CHEK1 Entrez,  Source	CHK1 checkpoint homolog (S. pombe)	2928	0.126	0.1574	Yes
13	FIGNL1	FIGNL1 Entrez,  Source	fidgetin-like 1	2930	0.126	0.1747	Yes
14	CHAF1B	CHAF1B Entrez,  Source	chromatin assembly factor 1, subunit B (p60)	2971	0.124	0.1902	Yes
15	POLA1	POLA1 Entrez,  Source	polymerase (DNA directed), alpha 1	2993	0.123	0.2062	Yes
16	TTK	TTK Entrez,  Source	TTK protein kinase	3042	0.119	0.2207	Yes
17	MMS22L			3118	0.115	0.2336	Yes
18	TIPIN	TIPIN Entrez,  Source	TIMELESS interacting protein	3139	0.114	0.2485	Yes
19	SKA1			3180	0.111	0.2622	Yes
20	SHCBP1	SHCBP1 Entrez,  Source	SHC SH2-domain binding protein 1	3202	0.110	0.2765	Yes
21	PLK4	PLK4 Entrez,  Source	polo-like kinase 4 (Drosophila)	3251	0.108	0.2895	Yes
22	BUB1	BUB1 Entrez,  Source	BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)	3261	0.107	0.3039	Yes
23	PRIM1	PRIM1 Entrez,  Source	primase, polypeptide 1, 49kDa	3268	0.107	0.3184	Yes
24	CASP8AP2	CASP8AP2 Entrez,  Source	CASP8 associated protein 2	3342	0.103	0.3298	Yes
25	CDC45			3350	0.103	0.3437	Yes
26	TIMELESS	TIMELESS Entrez,  Source	timeless homolog (Drosophila)	3361	0.102	0.3574	Yes
27	HAUS6			3501	0.097	0.3654	Yes
28	MCM10	MCM10 Entrez,  Source	MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)	3508	0.097	0.3785	Yes
29	CEP55	CEP55 Entrez,  Source	centrosomal protein 55kDa	3514	0.097	0.3916	Yes
30	BLM	BLM Entrez,  Source	Bloom syndrome	3626	0.092	0.3999	Yes
31	NCAPG	NCAPG Entrez,  Source	non-SMC condensin I complex, subunit G	3663	0.090	0.4110	Yes
32	DTL	DTL Entrez,  Source	denticleless homolog (Drosophila)	3696	0.089	0.4220	Yes
33	SMC4	SMC4 Entrez,  Source	structural maintenance of chromosomes 4	3717	0.088	0.4334	Yes
34	PPAT	PPAT Entrez,  Source	phosphoribosyl pyrophosphate amidotransferase	3759	0.087	0.4438	Yes
35	USP1	USP1 Entrez,  Source	ubiquitin specific peptidase 1	3988	0.086	0.4467	Yes
36	CENPN	CENPN Entrez,  Source	centromere protein N	4004	0.085	0.4579	Yes
37	EXO1	EXO1 Entrez,  Source	exonuclease 1	4079	0.083	0.4664	Yes
38	ORC2			4143	0.080	0.4750	Yes
39	NCAPG2	NCAPG2 Entrez,  Source	non-SMC condensin II complex, subunit G2	4155	0.080	0.4856	Yes
40	MASTL	MASTL Entrez,  Source	microtubule associated serine/threonine kinase-like	4210	0.078	0.4942	Yes
41	SMC6	SMC6 Entrez,  Source	structural maintenance of chromosomes 6	4260	0.077	0.5029	Yes
42	HAT1	HAT1 Entrez,  Source	histone acetyltransferase 1	4293	0.075	0.5120	Yes
43	ANLN	ANLN Entrez,  Source	anillin, actin binding protein	7973	0.074	0.3797	Yes
44	SRSF1			7992	0.073	0.3890	Yes
45	CCNA2	CCNA2 Entrez,  Source	cyclin A2	7999	0.073	0.3989	Yes
46	LYAR	LYAR Entrez,  Source	-	8134	0.072	0.4035	Yes
47	RBBP8	RBBP8 Entrez,  Source	retinoblastoma binding protein 8	8178	0.071	0.4116	Yes
48	TMPO	TMPO Entrez,  Source	thymopoietin	8207	0.070	0.4201	Yes
49	RBL1	RBL1 Entrez,  Source	retinoblastoma-like 1 (p107)	8225	0.070	0.4290	Yes
50	SMC2	SMC2 Entrez,  Source	structural maintenance of chromosomes 2	8352	0.067	0.4334	Yes
51	RIF1	RIF1 Entrez,  Source	RAP1 interacting factor homolog (yeast)	8355	0.067	0.4425	Yes
52	ZWILCH	ZWILCH Entrez,  Source	Zwilch, kinetochore associated, homolog (Drosophila)	8495	0.064	0.4459	Yes
53	BRCA1	BRCA1 Entrez,  Source	breast cancer 1, early onset	8541	0.063	0.4529	Yes
54	DNAJC2			8580	0.062	0.4600	Yes
55	MCM4	MCM4 Entrez,  Source	MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)	8582	0.062	0.4685	Yes
56	EZH2	EZH2 Entrez,  Source	enhancer of zeste homolog 2 (Drosophila)	8626	0.061	0.4753	Yes
57	WDHD1	WDHD1 Entrez,  Source	WD repeat and HMG-box DNA binding protein 1	8662	0.061	0.4823	Yes
58	TARDBP	TARDBP Entrez,  Source	TAR DNA binding protein	8912	0.060	0.4809	Yes
59	LIG1	LIG1 Entrez,  Source	ligase I, DNA, ATP-dependent	8928	0.059	0.4884	Yes
60	SLC12A2	SLC12A2 Entrez,  Source	solute carrier family 12 (sodium/potassium/chloride transporters), member 2	8967	0.059	0.4950	Yes
61	HMMR	HMMR Entrez,  Source	hyaluronan-mediated motility receptor (RHAMM)	9173	0.055	0.4947	Yes
62	POLE	POLE Entrez,  Source	polymerase (DNA directed), epsilon	9191	0.055	0.5015	Yes
63	TOP2A	TOP2A Entrez,  Source	topoisomerase (DNA) II alpha 170kDa	9270	0.054	0.5060	Yes
64	NUP85	NUP85 Entrez,  Source	nucleoporin 85kDa	9467	0.051	0.5054	Yes
65	KIF11	KIF11 Entrez,  Source	kinesin family member 11	9652	0.048	0.5049	Yes
66	NASP	NASP Entrez,  Source	nuclear autoantigenic sperm protein (histone-binding)	9757	0.047	0.5073	Yes
67	FANCI	FANCI Entrez,  Source	Fanconi anemia, complementation group I	9924	0.045	0.5070	Yes
68	HMGXB4			9941	0.044	0.5125	Yes
69	DEK	DEK Entrez,  Source	DEK oncogene (DNA binding)	9948	0.044	0.5184	Yes
70	RFC1	RFC1 Entrez,  Source	replication factor C (activator 1) 1, 145kDa	10084	0.042	0.5190	Yes
71	INCENP	INCENP Entrez,  Source	inner centromere protein antigens 135/155kDa	10322	0.039	0.5152	No
72	DNA2			10747	0.033	0.5034	No
73	DIS3			11406	0.026	0.4814	No
74	SHMT1	SHMT1 Entrez,  Source	serine hydroxymethyltransferase 1 (soluble)	12642	0.011	0.4351	No
75	PDZD11	PDZD11 Entrez,  Source	PDZ domain containing 11	13237	0.004	0.4126	No
76	CENPF	CENPF Entrez,  Source	centromere protein F, 350/400ka (mitosin)	13466	0.001	0.4039	No
77	SPAG5	SPAG5 Entrez,  Source	sperm associated antigen 5	13814	-0.003	0.3909	No
78	RAD54L	RAD54L Entrez,  Source	RAD54-like (S. cerevisiae)	14784	-0.016	0.3556	No
79	RAD51C	RAD51C Entrez,  Source	RAD51 homolog C (S. cerevisiae)	15118	-0.021	0.3456	No
80	MKI67	MKI67 Entrez,  Source	antigen identified by monoclonal antibody Ki-67	15149	-0.022	0.3474	No
81	FANCA	FANCA Entrez,  Source	Fanconi anemia, complementation group A	15269	-0.024	0.3461	No
82	PEG3	PEG3 Entrez,  Source	paternally expressed 3	15338	-0.024	0.3467	No
83	TCF19	TCF19 Entrez,  Source	transcription factor 19 (SC1)	16559	-0.040	0.3049	No
84	ATM	ATM Entrez,  Source	ataxia telangiectasia mutated (includes complementation groups A, C and D)	17577	-0.060	0.2738	No
85	NET1	NET1 Entrez,  Source	neuroepithelial cell transforming gene 1	17779	-0.065	0.2750	No
86	SLC4A4	SLC4A4 Entrez,  Source	solute carrier family 4, sodium bicarbonate cotransporter, member 4	18269	-0.078	0.2667	No
87	TTPA	TTPA Entrez,  Source	tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)	21296	-0.209	0.1783	No

Fig 2: ZHANG_TLX_TARGETS_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: ZHANG_TLX_TARGETS_DN: Random ES distribution   
Gene set null distribution of ES for ZHANG_TLX_TARGETS_DN