DatasetKO_vs_WT.KO_vs_WT.cls#KO_versus_WT.KO_vs_WT.cls#KO_versus_WT_repos
PhenotypeKO_vs_WT.cls#KO_versus_WT_repos
Upregulated in classWT
GeneSetREACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION
Enrichment Score (ES)-0.60500854
Normalized Enrichment Score (NES)-1.6838754
Nominal p-value0.04183267
FDR q-value0.827123
FWER p-Value0.836
Table: GSEA Results Summary



Fig 1: Enrichment plot: REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1Me2Me25071.1100.0130No
2Aldh1b1Aldh1b15611.0700.0430No
3StarStar8440.9360.0599No
4Aldh18a1Aldh18a137740.446-0.0438No
5Bdh1Bdh162040.286-0.1322No
6LdhdLdhd98440.125-0.2739No
7Acot3Acot3104850.099-0.2965No
8Ndufa2Ndufa2109910.080-0.3142No
9Hmgcs2Hmgcs2111180.075-0.3170No
10Slc25a5Slc25a5115430.060-0.3322No
11Afg3l2Afg3l2118520.049-0.3430No
12Smdt1Smdt1127170.019-0.3770No
13Mrps10Mrps1014347-0.039-0.4409No
14Acad8Acad814534-0.046-0.4469No
15AppApp15780-0.090-0.4940No
16Spg7Spg716214-0.107-0.5081No
17Ssbp1Ssbp116475-0.116-0.5149No
18Atp5pdAtp5pd17242-0.146-0.5412No
19Mrpl12Mrpl1217265-0.147-0.5376No
20Pdk1Pdk117716-0.165-0.5507No
21Aldh2Aldh218034-0.179-0.5579No
22Shmt2Shmt218278-0.190-0.5619No
23Idh2Idh218928-0.218-0.5813No
24Ndufv1Ndufv119255-0.232-0.5874No
25PmpcaPmpca19307-0.235-0.5824No
26Htra2Htra219875-0.264-0.5971Yes
27Glud1Glud119892-0.265-0.5898Yes
28PrkacaPrkaca20069-0.275-0.5886Yes
29ClppClpp20106-0.277-0.5817Yes
30Mdh2Mdh220172-0.280-0.5759Yes
31Iars2Iars220346-0.289-0.5741Yes
32UqcrqUqcrq20690-0.309-0.5785Yes
33FechFech20692-0.310-0.5693Yes
34Fh1Fh120746-0.312-0.5620Yes
35Oxct1Oxct120831-0.317-0.5559Yes
36Mrpl32Mrpl3220877-0.319-0.5481Yes
37TwnkTwnk20879-0.319-0.5386Yes
38Lonp1Lonp120881-0.319-0.5290Yes
39Ndufa13Ndufa1320896-0.320-0.5200Yes
40Aco2Aco220932-0.322-0.5117Yes
41OxsmOxsm21467-0.358-0.5223Yes
42Acat1Acat121629-0.370-0.5176Yes
43Ndufs3Ndufs321648-0.372-0.5072Yes
44Atp5mgAtp5mg21756-0.379-0.5001Yes
45TfamTfam21956-0.395-0.4962Yes
46PdhbPdhb21963-0.395-0.4846Yes
47Atp5pfAtp5pf22184-0.413-0.4809Yes
48Hspa9Hspa922229-0.416-0.4702Yes
49Cox5bCox5b22296-0.423-0.4601Yes
50Atp5poAtp5po22300-0.423-0.4476Yes
51Atp5f1cAtp5f1c22331-0.426-0.4360Yes
52Mrps2Mrps222612-0.455-0.4335Yes
53OgdhOgdh22746-0.468-0.4248Yes
54Suclg2Suclg222786-0.473-0.4121Yes
55Cox5aCox5a22788-0.474-0.3979Yes
56AcadsbAcadsb22798-0.475-0.3841Yes
57Hsd17b10Hsd17b1022799-0.475-0.3698Yes
58mt-Co1mt-Co122956-0.493-0.3612Yes
59Ndufv3Ndufv323094-0.507-0.3515Yes
60Pdha1Pdha123160-0.515-0.3386Yes
61Atp5f1bAtp5f1b23271-0.531-0.3271Yes
62Atp5f1aAtp5f1a23289-0.533-0.3117Yes
63Acot2Acot223356-0.542-0.2981Yes
64Uqcrc2Uqcrc223430-0.554-0.2844Yes
65CsCs23678-0.593-0.2764Yes
66DldDld23723-0.603-0.2601Yes
67PccbPccb23765-0.612-0.2434Yes
68Ndufs1Ndufs123812-0.621-0.2266Yes
69HadhHadh23900-0.638-0.2109Yes
70mt-Atp6mt-Atp624010-0.668-0.1952Yes
71Hspd1Hspd124017-0.671-0.1753Yes
72ClpxClpx24190-0.723-0.1605Yes
73Eci1Eci124279-0.753-0.1414Yes
74DbtDbt24433-0.805-0.1234Yes
75Idh3aIdh3a24435-0.805-0.0992Yes
76Alas1Alas124642-0.912-0.0801Yes
77Nadk2Nadk224663-0.932-0.0529Yes
78Acot1Acot124805-1.091-0.0258Yes
79Ech1Ech124903-1.2600.0082Yes
Table: GSEA details [plain text format]



Fig 2: REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION: Random ES distribution   
Gene set null distribution of ES for REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION