Details for gene set WP_ALZHEIMERS_DISEASE[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WT.KO_vs_WT.cls#KO_versus_WT.KO_vs_WT.cls#KO_versus_WT_repos
Phenotype	KO_vs_WT.cls#KO_versus_WT_repos
Upregulated in class	WT
GeneSet	WP_ALZHEIMERS_DISEASE
Enrichment Score (ES)	-0.3412342
Normalized Enrichment Score (NES)	-1.2929441
Nominal p-value	0.18106996
FDR q-value	0.6005864
FWER p-Value	0.963

Fig 1: Enrichment plot: WP_ALZHEIMERS_DISEASE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Casp12	Casp12	264	1.346	0.0486	No
2	Ryr3	Ryr3	706	0.987	0.0743	No
3	Atp2a1	Atp2a1	1226	0.802	0.0888	No
4	Apoe	Apoe	1983	0.650	0.0872	No
5	Mapt	Mapt	2706	0.552	0.0826	No
6	Cacna1d	Cacna1d	3994	0.430	0.0501	No
7	Apaf1	Apaf1	4244	0.410	0.0581	No
8	Bid	Bid	4255	0.409	0.0757	No
9	Cdk5r1	Cdk5r1	4506	0.391	0.0829	No
10	Lrp1	Lrp1	4587	0.385	0.0966	No
11	Eif2ak3	Eif2ak3	4721	0.376	0.1078	No
12	Atf6	Atf6	6267	0.283	0.0585	No
13	Chp2	Chp2	7652	0.214	0.0126	No
14	Nos1	Nos1	7864	0.205	0.0132	No
15	Grin2a	Grin2a	8583	0.174	-0.0078	No
16	Tnf	Tnf	9692	0.130	-0.0463	No
17	Ppp3cc	Ppp3cc	9779	0.127	-0.0442	No
18	Capn1	Capn1	9795	0.126	-0.0393	No
19	Plcb1	Plcb1	10190	0.111	-0.0501	No
20	Grin2c	Grin2c	10264	0.108	-0.0483	No
21	Casp9	Casp9	10396	0.102	-0.0490	No
22	Bad	Bad	11045	0.078	-0.0715	No
23	Cdk5	Cdk5	11334	0.067	-0.0800	No
24	Snca	Snca	11513	0.061	-0.0844	No
25	Plcb4	Plcb4	11780	0.051	-0.0928	No
26	Trp53	Trp53	11872	0.048	-0.0943	No
27	Il1b	Il1b	11899	0.048	-0.0933	No
28	Casp8	Casp8	11927	0.046	-0.0923	No
29	Itpr1	Itpr1	12403	0.029	-0.1100	No
30	Psenen	Psenen	13009	0.008	-0.1338	No
31	Psen2	Psen2	13191	0.002	-0.1409	No
32	Psen1	Psen1	13832	-0.021	-0.1656	No
33	Itpr3	Itpr3	13983	-0.026	-0.1705	No
34	Capn2	Capn2	14053	-0.029	-0.1719	No
35	Ide	Ide	14583	-0.048	-0.1910	No
36	Adam17	Adam17	15008	-0.063	-0.2051	No
37	Gsk3b	Gsk3b	15642	-0.086	-0.2266	No
38	App	App	15780	-0.090	-0.2281	No
39	Fas	Fas	15847	-0.093	-0.2267	No
40	Casp7	Casp7	16604	-0.121	-0.2516	No
41	Gnaq	Gnaq	16673	-0.124	-0.2488	No
42	Chp1	Chp1	16855	-0.131	-0.2503	No
43	Grin2d	Grin2d	17165	-0.143	-0.2564	No
44	Itpr2	Itpr2	17178	-0.144	-0.2505	No
45	Casp3	Casp3	17391	-0.152	-0.2523	No
46	Atp2a3	Atp2a3	17550	-0.158	-0.2517	No
47	Adam10	Adam10	17699	-0.165	-0.2504	No
48	Plcb3	Plcb3	18137	-0.184	-0.2597	No
49	Mapk1	Mapk1	18437	-0.197	-0.2630	No
50	Tnfrsf1a	Tnfrsf1a	18676	-0.207	-0.2634	No
51	Nae1	Nae1	18873	-0.216	-0.2617	No
52	Mapk3	Mapk3	19068	-0.224	-0.2596	No
53	Ncstn	Ncstn	20379	-0.291	-0.2992	No
54	Ppp3r1	Ppp3r1	20610	-0.304	-0.2950	No
55	Aph1a	Aph1a	20894	-0.320	-0.2923	No
56	Ern1	Ern1	21045	-0.330	-0.2838	No
57	Ppp3ca	Ppp3ca	22485	-0.441	-0.3219	Yes
58	Plcb2	Plcb2	22534	-0.446	-0.3042	Yes
59	Calml3	Calml3	22682	-0.462	-0.2898	Yes
60	Calm2	Calm2	22709	-0.465	-0.2704	Yes
61	Hsd17b10	Hsd17b10	22799	-0.475	-0.2531	Yes
62	Cacna1c	Cacna1c	23124	-0.511	-0.2436	Yes
63	Lpl	Lpl	23266	-0.531	-0.2259	Yes
64	Bace1	Bace1	23547	-0.569	-0.2121	Yes
65	Ppp3cb	Ppp3cb	24135	-0.706	-0.2045	Yes
66	Atp2a2	Atp2a2	24681	-0.950	-0.1845	Yes
67	Mme	Mme	24977	-1.448	-0.1327	Yes
68	Cacna1s	Cacna1s	24991	-1.485	-0.0680	Yes
69	Apbb1	Apbb1	25035	-1.653	0.0029	Yes

Fig 2: WP_ALZHEIMERS_DISEASE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: WP_ALZHEIMERS_DISEASE: Random ES distribution   
Gene set null distribution of ES for WP_ALZHEIMERS_DISEASE