Details for gene set REACTOME_CELLULAR_SENESCENCE[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WTandHET.KO_vs_WTandHET.cls#WT_versus_KO
Phenotype	KO_vs_WTandHET.cls#WT_versus_KO
Upregulated in class	KO
GeneSet	REACTOME_CELLULAR_SENESCENCE
Enrichment Score (ES)	-0.41990307
Normalized Enrichment Score (NES)	-1.8177359
Nominal p-value	0.0
FDR q-value	0.20990208
FWER p-Value	0.37

Fig 1: Enrichment plot: REACTOME_CELLULAR_SENESCENCE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Cebpb	Cebpb	1581	0.709	-0.0482	No
2	Tnik	Tnik	1845	0.640	-0.0422	No
3	Uba52	Uba52	2497	0.523	-0.0558	No
4	Jun	Jun	2502	0.522	-0.0420	No
5	Map2k3	Map2k3	3009	0.450	-0.0514	No
6	Mapk14	Mapk14	3143	0.436	-0.0454	No
7	Mapk9	Mapk9	3187	0.432	-0.0356	No
8	H2az2	H2az2	3298	0.422	-0.0290	No
9	Cdkn1b	Cdkn1b	3591	0.394	-0.0308	No
10	Ets1	Ets1	4087	0.351	-0.0425	No
11	Ets2	Ets2	4130	0.348	-0.0349	No
12	H1f0	H1f0	4305	0.333	-0.0334	No
13	Map3k5	Map3k5	4337	0.332	-0.0258	No
14	Rb1	Rb1	4551	0.315	-0.0264	No
15	Cdk2	Cdk2	4769	0.298	-0.0276	No
16	H1f5	H1f5	5115	0.275	-0.0349	No
17	Mapkapk5	Mapkapk5	5525	0.247	-0.0457	No
18	Mapk3	Mapk3	5607	0.243	-0.0426	No
19	Ube2d1	Ube2d1	6179	0.213	-0.0612	No
20	Ubb	Ubb	6345	0.205	-0.0627	No
21	Mdm4	Mdm4	6503	0.197	-0.0641	No
22	Ubc	Ubc	6804	0.183	-0.0719	No
23	Ep400	Ep400	6847	0.181	-0.0688	No
24	Map2k7	Map2k7	6864	0.180	-0.0647	No
25	Anapc16	Anapc16	6932	0.177	-0.0628	No
26	Hmga1b	Hmga1b	7027	0.172	-0.0622	No
27	Mapkapk2	Mapkapk2	7469	0.152	-0.0768	No
28	Ube2s	Ube2s	7806	0.137	-0.0875	No
29	Cdc23	Cdc23	7909	0.132	-0.0883	No
30	Asf1a	Asf1a	8010	0.127	-0.0891	No
31	Id1	Id1	8084	0.124	-0.0889	No
32	Anapc7	Anapc7	8321	0.114	-0.0959	No
33	Uba52rt	Uba52rt	8363	0.113	-0.0946	No
34	Ehmt1	Ehmt1	8428	0.110	-0.0943	No
35	Mdm2	Mdm2	8497	0.107	-0.0944	No
36	Terf2ip	Terf2ip	8691	0.100	-0.0999	No
37	Mapk1	Mapk1	8711	0.099	-0.0980	No
38	Mapk8	Mapk8	9423	0.072	-0.1263	No
39	Hira	Hira	9611	0.064	-0.1325	No
40	Ube2e1	Ube2e1	9738	0.059	-0.1363	No
41	Ubn1	Ubn1	9746	0.058	-0.1351	No
42	Map2k4	Map2k4	9795	0.056	-0.1356	No
43	Cdc27	Cdc27	10253	0.040	-0.1539	No
44	Fzr1	Fzr1	10288	0.039	-0.1543	No
45	Cdkn1c	Cdkn1c	10360	0.036	-0.1564	No
46	Mapk7	Mapk7	10578	0.028	-0.1648	No
47	H2bc21	H2bc21	10626	0.026	-0.1661	No
48	Anapc5	Anapc5	10627	0.026	-0.1654	No
49	Terf1	Terf1	10651	0.026	-0.1657	No
50	Rbbp7	Rbbp7	10693	0.024	-0.1668	No
51	Terf2	Terf2	10857	0.019	-0.1732	No
52	Suz12	Suz12	11057	0.012	-0.1813	No
53	Kdm6b	Kdm6b	11078	0.011	-0.1819	No
54	Rad50	Rad50	11119	0.010	-0.1833	No
55	Cdk6	Cdk6	11294	0.004	-0.1906	No
56	Anapc15	Anapc15	11353	0.002	-0.1930	No
57	Nbn	Nbn	11849	-0.016	-0.2137	No
58	Acd	Acd	12041	-0.022	-0.2212	No
59	Map4k4	Map4k4	12089	-0.024	-0.2225	No
60	Anapc1	Anapc1	12329	-0.032	-0.2318	No
61	Kat5	Kat5	12362	-0.033	-0.2323	No
62	Rps6ka3	Rps6ka3	12431	-0.036	-0.2343	No
63	H2ax	H2ax	12602	-0.042	-0.2404	No
64	Pot1a	Pot1a	12830	-0.051	-0.2487	No
65	Anapc4	Anapc4	13395	-0.070	-0.2707	No
66	H2aj	H2aj	13418	-0.071	-0.2698	No
67	Eed	Eed	13495	-0.075	-0.2710	No
68	Anapc11	Anapc11	13583	-0.078	-0.2726	No
69	Cabin1	Cabin1	13900	-0.091	-0.2836	No
70	Rbbp4	Rbbp4	13929	-0.092	-0.2823	No
71	H2ac19	H2ac19	14094	-0.098	-0.2867	No
72	Ehmt2	Ehmt2	14335	-0.108	-0.2940	No
73	Anapc2	Anapc2	14383	-0.110	-0.2930	No
74	Ccna1	Ccna1	14516	-0.115	-0.2955	No
75	Ccne2	Ccne2	15008	-0.135	-0.3128	No
76	Cdc26	Cdc26	15052	-0.137	-0.3109	No
77	Erf	Erf	15218	-0.143	-0.3141	No
78	Ezh2	Ezh2	15366	-0.149	-0.3163	No
79	Rps27a	Rps27a	15542	-0.156	-0.3196	No
80	Txn1	Txn1	15879	-0.170	-0.3293	No
81	Mink1	Mink1	15940	-0.172	-0.3272	No
82	Cdc16	Cdc16	16115	-0.180	-0.3298	No
83	Atm	Atm	16155	-0.182	-0.3266	No
84	H4c3	H4c3	16991	-0.221	-0.3562	No
85	Anapc10	Anapc10	17025	-0.223	-0.3516	No
86	Mre11a	Mre11a	17135	-0.228	-0.3501	No
87	Ccna2	Ccna2	17693	-0.255	-0.3669	No
88	Lmnb1	Lmnb1	18732	-0.306	-0.4029	No
89	Fos	Fos	18750	-0.307	-0.3953	No
90	Trp53	Trp53	18947	-0.319	-0.3951	No
91	H1f2	H1f2	19531	-0.357	-0.4103	Yes
92	Rps6ka2	Rps6ka2	19698	-0.369	-0.4075	Yes
93	Cdkn2b	Cdkn2b	19762	-0.373	-0.4002	Yes
94	H2bc22	H2bc22	19944	-0.388	-0.3975	Yes
95	Cdkn1a	Cdkn1a	20276	-0.417	-0.4003	Yes
96	Rps6ka1	Rps6ka1	20391	-0.427	-0.3937	Yes
97	Mapk11	Mapk11	20449	-0.434	-0.3845	Yes
98	Cdk4	Cdk4	20534	-0.442	-0.3762	Yes
99	H4c4	H4c4	20799	-0.470	-0.3748	Yes
100	H4c14	H4c14	20944	-0.487	-0.3679	Yes
101	Hmga2	Hmga2	21331	-0.537	-0.3699	Yes
102	Mapk10	Mapk10	21374	-0.543	-0.3571	Yes
103	Ube2c	Ube2c	21424	-0.551	-0.3444	Yes
104	Mapkapk3	Mapkapk3	21469	-0.558	-0.3313	Yes
105	H1f1	H1f1	21780	-0.609	-0.3281	Yes
106	H2bc9	H2bc9	21990	-0.652	-0.3196	Yes
107	H1f4	H1f4	22294	-0.729	-0.3129	Yes
108	H2bc8	H2bc8	22616	-0.834	-0.3041	Yes
109	Hmga1	Hmga1	22675	-0.864	-0.2834	Yes
110	H4c11	H4c11	22862	-0.951	-0.2658	Yes
111	H4c8	H4c8	22866	-0.953	-0.2404	Yes
112	H4c9	H4c9	22911	-0.975	-0.2161	Yes
113	Map2k6	Map2k6	22945	-0.993	-0.1909	Yes
114	H2ac7	H2ac7	22957	-1.001	-0.1645	Yes
115	H2bc4	H2bc4	23076	-1.092	-0.1402	Yes
116	Ccne1	Ccne1	23202	-1.192	-0.1136	Yes
117	H2bc6	H2bc6	23434	-1.594	-0.0806	Yes
118	H2bc3	H2bc3	23451	-1.655	-0.0369	Yes
119	H2ac6	H2ac6	23459	-1.688	0.0081	Yes

Fig 2: REACTOME_CELLULAR_SENESCENCE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_CELLULAR_SENESCENCE: Random ES distribution   
Gene set null distribution of ES for REACTOME_CELLULAR_SENESCENCE