Details for gene set REACTOME_G2_M_CHECKPOINTS[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WTandHET.KO_vs_WTandHET.cls#WT_versus_KO
Phenotype	KO_vs_WTandHET.cls#WT_versus_KO
Upregulated in class	KO
GeneSet	REACTOME_G2_M_CHECKPOINTS
Enrichment Score (ES)	-0.50884354
Normalized Enrichment Score (NES)	-1.7687714
Nominal p-value	0.00811359
FDR q-value	0.13153124
FWER p-Value	0.499

Fig 1: Enrichment plot: REACTOME_G2_M_CHECKPOINTS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Rnf8	Rnf8	2044	0.603	-0.0717	No
2	Uba52	Uba52	2497	0.523	-0.0777	No
3	Wee1	Wee1	2632	0.502	-0.0707	No
4	Ube2v2	Ube2v2	3651	0.388	-0.1042	No
5	Cdk2	Cdk2	4769	0.298	-0.1442	No
6	Ubb	Ubb	6345	0.205	-0.2060	No
7	Ubc	Ubc	6804	0.183	-0.2208	No
8	Ywhae	Ywhae	7338	0.158	-0.2395	No
9	Cdc25a	Cdc25a	7384	0.156	-0.2375	No
10	Adrm1	Adrm1	7431	0.154	-0.2355	No
11	Uba52rt	Uba52rt	8363	0.113	-0.2723	No
12	Psmb6	Psmb6	8529	0.106	-0.2766	No
13	Brcc3	Brcc3	9647	0.062	-0.3225	No
14	Ywhaz	Ywhaz	9745	0.058	-0.3252	No
15	Ube2n	Ube2n	9781	0.057	-0.3253	No
16	Psmd3	Psmd3	9872	0.054	-0.3277	No
17	Hus1	Hus1	9963	0.051	-0.3303	No
18	Psmd1	Psmd1	10060	0.047	-0.3332	No
19	Herc2	Herc2	10197	0.042	-0.3379	No
20	Ywhab	Ywhab	10624	0.027	-0.3553	No
21	H2bc21	H2bc21	10626	0.026	-0.3547	No
22	Psmb4	Psmb4	11008	0.014	-0.3706	No
23	Rad50	Rad50	11119	0.010	-0.3750	No
24	Rnf168	Rnf168	11399	0.000	-0.3868	No
25	Psmb3	Psmb3	11401	0.000	-0.3869	No
26	Psmd7	Psmd7	11431	-0.001	-0.3881	No
27	Psmc3	Psmc3	11603	-0.007	-0.3952	No
28	Nsd2	Nsd2	11698	-0.010	-0.3989	No
29	Rad1	Rad1	11737	-0.011	-0.4003	No
30	Nbn	Nbn	11849	-0.016	-0.4046	No
31	Top3a	Top3a	11971	-0.020	-0.4092	No
32	Chek2	Chek2	12207	-0.028	-0.4185	No
33	Psmc6	Psmc6	12222	-0.028	-0.4184	No
34	Orc4	Orc4	12240	-0.029	-0.4184	No
35	Rpa3	Rpa3	12241	-0.029	-0.4176	No
36	Kat5	Kat5	12362	-0.033	-0.4219	No
37	Psmb5	Psmb5	12516	-0.039	-0.4274	No
38	H2ax	H2ax	12602	-0.042	-0.4300	No
39	Psmc2	Psmc2	12801	-0.049	-0.4372	No
40	Psma7	Psma7	12887	-0.052	-0.4395	No
41	Trp53bp1	Trp53bp1	12947	-0.055	-0.4406	No
42	Psmd11	Psmd11	12988	-0.056	-0.4409	No
43	Psmd6	Psmd6	13028	-0.057	-0.4411	No
44	Psmc5	Psmc5	13151	-0.062	-0.4447	No
45	Psma2	Psma2	13246	-0.066	-0.4471	No
46	Rfc2	Rfc2	13247	-0.066	-0.4454	No
47	Atrip	Atrip	13322	-0.068	-0.4468	No
48	Psma3	Psma3	13458	-0.073	-0.4507	No
49	Orc5	Orc5	13490	-0.074	-0.4502	No
50	Psmd13	Psmd13	13505	-0.075	-0.4489	No
51	Psmc4	Psmc4	13831	-0.087	-0.4605	No
52	Ywhaq	Ywhaq	13911	-0.091	-0.4616	No
53	Rpa1	Rpa1	14023	-0.095	-0.4639	No
54	Uimc1	Uimc1	14232	-0.104	-0.4701	No
55	Rad9a	Rad9a	14430	-0.112	-0.4756	No
56	Ccna1	Ccna1	14516	-0.115	-0.4763	No
57	Pias4	Pias4	14676	-0.121	-0.4800	No
58	Psmd12	Psmd12	14791	-0.127	-0.4817	No
59	Ccnb2	Ccnb2	15026	-0.136	-0.4882	No
60	Babam1	Babam1	15036	-0.137	-0.4851	No
61	Orc6	Orc6	15133	-0.140	-0.4856	No
62	Psmb1	Psmb1	15331	-0.148	-0.4903	No
63	Rps27a	Rps27a	15542	-0.156	-0.4953	No
64	Brip1	Brip1	15862	-0.170	-0.5046	Yes
65	Rhno1	Rhno1	15878	-0.170	-0.5009	Yes
66	Orc2	Orc2	15921	-0.171	-0.4983	Yes
67	Psma4	Psma4	16046	-0.177	-0.4991	Yes
68	Ywhag	Ywhag	16047	-0.177	-0.4947	Yes
69	Orc3	Orc3	16093	-0.179	-0.4921	Yes
70	Atm	Atm	16155	-0.182	-0.4901	Yes
71	Ywhah	Ywhah	16221	-0.184	-0.4882	Yes
72	Rad9b	Rad9b	16301	-0.188	-0.4868	Yes
73	Psmb7	Psmb7	16359	-0.190	-0.4844	Yes
74	Rbbp8	Rbbp8	16653	-0.205	-0.4917	Yes
75	Rmi1	Rmi1	16810	-0.212	-0.4929	Yes
76	Psmc1	Psmc1	16835	-0.213	-0.4886	Yes
77	H4c3	H4c3	16991	-0.221	-0.4896	Yes
78	Psmb2	Psmb2	17120	-0.227	-0.4893	Yes
79	Mre11a	Mre11a	17135	-0.228	-0.4841	Yes
80	Psmd8	Psmd8	17312	-0.236	-0.4857	Yes
81	Wrn	Wrn	17358	-0.238	-0.4816	Yes
82	Topbp1	Topbp1	17410	-0.240	-0.4776	Yes
83	Psma1	Psma1	17500	-0.245	-0.4752	Yes
84	Ccna2	Ccna2	17693	-0.255	-0.4769	Yes
85	Psmd14	Psmd14	17703	-0.255	-0.4709	Yes
86	Sfn	Sfn	17762	-0.259	-0.4668	Yes
87	Psma5	Psma5	17770	-0.259	-0.4605	Yes
88	Psmd2	Psmd2	17847	-0.262	-0.4571	Yes
89	Psma6	Psma6	18071	-0.273	-0.4597	Yes
90	Rpa2	Rpa2	18494	-0.294	-0.4703	Yes
91	Bard1	Bard1	18586	-0.299	-0.4666	Yes
92	Cdc25c	Cdc25c	18736	-0.306	-0.4652	Yes
93	Trp53	Trp53	18947	-0.319	-0.4660	Yes
94	Dbf4	Dbf4	19043	-0.324	-0.4619	Yes
95	Cdk1	Cdk1	19126	-0.330	-0.4570	Yes
96	Rad17	Rad17	19197	-0.334	-0.4516	Yes
97	Ccnb1	Ccnb1	19364	-0.345	-0.4499	Yes
98	Pkmyt1	Pkmyt1	19454	-0.352	-0.4448	Yes
99	Cdc7	Cdc7	19580	-0.360	-0.4410	Yes
100	H2bc22	H2bc22	19944	-0.388	-0.4467	Yes
101	Rfc3	Rfc3	20047	-0.396	-0.4410	Yes
102	Mdc1	Mdc1	20214	-0.411	-0.4377	Yes
103	Babam2	Babam2	20247	-0.414	-0.4286	Yes
104	Dna2	Dna2	20542	-0.443	-0.4299	Yes
105	Rfc5	Rfc5	20606	-0.450	-0.4211	Yes
106	Blm	Blm	20616	-0.451	-0.4101	Yes
107	Brca1	Brca1	20642	-0.453	-0.3997	Yes
108	Mcm2	Mcm2	20727	-0.463	-0.3916	Yes
109	H4c4	H4c4	20799	-0.470	-0.3827	Yes
110	Abraxas1	Abraxas1	20826	-0.473	-0.3719	Yes
111	H4c14	H4c14	20944	-0.487	-0.3645	Yes
112	Gtse1	Gtse1	21297	-0.532	-0.3660	Yes
113	Mcm3	Mcm3	21351	-0.540	-0.3546	Yes
114	Mcm4	Mcm4	21406	-0.549	-0.3431	Yes
115	Mcm7	Mcm7	21501	-0.561	-0.3329	Yes
116	Clspn	Clspn	21535	-0.567	-0.3200	Yes
117	Mcm5	Mcm5	21550	-0.568	-0.3062	Yes
118	Cdc6	Cdc6	21663	-0.588	-0.2961	Yes
119	Rmi2	Rmi2	21755	-0.604	-0.2847	Yes
120	Exo1	Exo1	21832	-0.620	-0.2723	Yes
121	Mcm6	Mcm6	21940	-0.641	-0.2606	Yes
122	H2bc9	H2bc9	21990	-0.652	-0.2462	Yes
123	Cdc45	Cdc45	22077	-0.673	-0.2329	Yes
124	Orc1	Orc1	22163	-0.693	-0.2190	Yes
125	Chek1	Chek1	22334	-0.739	-0.2075	Yes
126	Mcm8	Mcm8	22374	-0.749	-0.1902	Yes
127	Mcm10	Mcm10	22507	-0.793	-0.1758	Yes
128	Rfc4	Rfc4	22548	-0.808	-0.1571	Yes
129	H2bc8	H2bc8	22616	-0.834	-0.1389	Yes
130	H4c11	H4c11	22862	-0.951	-0.1252	Yes
131	H4c8	H4c8	22866	-0.953	-0.1013	Yes
132	H4c9	H4c9	22911	-0.975	-0.0785	Yes
133	H2bc4	H2bc4	23076	-1.092	-0.0578	Yes
134	H2bc6	H2bc6	23434	-1.594	-0.0327	Yes
135	H2bc3	H2bc3	23451	-1.655	0.0084	Yes

Fig 2: REACTOME_G2_M_CHECKPOINTS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_G2_M_CHECKPOINTS: Random ES distribution   
Gene set null distribution of ES for REACTOME_G2_M_CHECKPOINTS