Details for gene set REACTOME_HOMOLOGY_DIRECTED_REPAIR[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WTandHET.KO_vs_WTandHET.cls#WT_versus_KO
Phenotype	KO_vs_WTandHET.cls#WT_versus_KO
Upregulated in class	KO
GeneSet	REACTOME_HOMOLOGY_DIRECTED_REPAIR
Enrichment Score (ES)	-0.52028906
Normalized Enrichment Score (NES)	-1.8113958
Nominal p-value	0.001996008
FDR q-value	0.17181504
FWER p-Value	0.384

Fig 1: Enrichment plot: REACTOME_HOMOLOGY_DIRECTED_REPAIR   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Rnf8	Rnf8	2044	0.603	-0.0703	No
2	Uba52	Uba52	2497	0.523	-0.0752	No
3	Ube2v2	Ube2v2	3651	0.388	-0.1136	No
4	Xrcc2	Xrcc2	3820	0.373	-0.1105	No
5	Xrcc3	Xrcc3	4635	0.308	-0.1366	No
6	Cdk2	Cdk2	4769	0.298	-0.1341	No
7	Ubb	Ubb	6345	0.205	-0.1954	No
8	Ubc	Ubc	6804	0.183	-0.2099	No
9	Sumo2	Sumo2	7131	0.167	-0.2192	No
10	Slx1b	Slx1b	7177	0.165	-0.2166	No
11	Ercc1	Ercc1	7412	0.155	-0.2223	No
12	Ppp4r2	Ppp4r2	7673	0.143	-0.2294	No
13	Parp2	Parp2	7751	0.139	-0.2289	No
14	Uba52rt	Uba52rt	8363	0.113	-0.2517	No
15	Abl1	Abl1	8455	0.109	-0.2526	No
16	Sirt6	Sirt6	8788	0.096	-0.2641	No
17	Rad52	Rad52	9222	0.080	-0.2803	No
18	Rad51ap1	Rad51ap1	9258	0.079	-0.2797	No
19	Brcc3	Brcc3	9647	0.062	-0.2944	No
20	Ube2n	Ube2n	9781	0.057	-0.2985	No
21	Hus1	Hus1	9963	0.051	-0.3048	No
22	Herc2	Herc2	10197	0.042	-0.3136	No
23	Ube2i	Ube2i	10246	0.041	-0.3145	No
24	H2bc21	H2bc21	10626	0.026	-0.3299	No
25	Rad50	Rad50	11119	0.010	-0.3505	No
26	Eme2	Eme2	11222	0.006	-0.3547	No
27	Rnf168	Rnf168	11399	0.000	-0.3622	No
28	Ercc4	Ercc4	11584	-0.006	-0.3698	No
29	Nsd2	Nsd2	11698	-0.010	-0.3743	No
30	Rad1	Rad1	11737	-0.011	-0.3756	No
31	Rnf4	Rnf4	11761	-0.012	-0.3763	No
32	Nbn	Nbn	11849	-0.016	-0.3795	No
33	Top3a	Top3a	11971	-0.020	-0.3841	No
34	Rpa3	Rpa3	12241	-0.029	-0.3948	No
35	Kat5	Kat5	12362	-0.033	-0.3990	No
36	H2ax	H2ax	12602	-0.042	-0.4080	No
37	Trp53bp1	Trp53bp1	12947	-0.055	-0.4211	No
38	Palb2	Palb2	13065	-0.058	-0.4245	No
39	Brca2	Brca2	13090	-0.060	-0.4239	No
40	Rfc2	Rfc2	13247	-0.066	-0.4287	No
41	Rfc1	Rfc1	13270	-0.066	-0.4278	No
42	Atrip	Atrip	13322	-0.068	-0.4281	No
43	Xrcc1	Xrcc1	13637	-0.080	-0.4393	No
44	Pole3	Pole3	13712	-0.082	-0.4401	No
45	Ppp4c	Ppp4c	13919	-0.091	-0.4464	No
46	Rpa1	Rpa1	14023	-0.095	-0.4482	No
47	Mus81	Mus81	14065	-0.097	-0.4473	No
48	Uimc1	Uimc1	14232	-0.104	-0.4515	No
49	Rad9a	Rad9a	14430	-0.112	-0.4568	No
50	Ccna1	Ccna1	14516	-0.115	-0.4572	No
51	Parp1	Parp1	14523	-0.115	-0.4543	No
52	Pias4	Pias4	14676	-0.121	-0.4575	No
53	Pole4	Pole4	14930	-0.132	-0.4646	No
54	Babam1	Babam1	15036	-0.137	-0.4653	No
55	Lig3	Lig3	15120	-0.140	-0.4650	No
56	Pold4	Pold4	15395	-0.150	-0.4725	No
57	Polk	Polk	15479	-0.153	-0.4718	No
58	Rps27a	Rps27a	15542	-0.156	-0.4702	No
59	Brip1	Brip1	15862	-0.170	-0.4791	No
60	Rhno1	Rhno1	15878	-0.170	-0.4751	No
61	Atm	Atm	16155	-0.182	-0.4819	No
62	Pold3	Pold3	16273	-0.187	-0.4817	No
63	Rad9b	Rad9b	16301	-0.188	-0.4777	No
64	Pole2	Pole2	16365	-0.191	-0.4752	No
65	Slx4	Slx4	16650	-0.205	-0.4816	No
66	Rbbp8	Rbbp8	16653	-0.205	-0.4761	No
67	Rmi1	Rmi1	16810	-0.212	-0.4769	No
68	H4c3	H4c3	16991	-0.221	-0.4785	No
69	Mre11a	Mre11a	17135	-0.228	-0.4783	No
70	Wrn	Wrn	17358	-0.238	-0.4812	No
71	Topbp1	Topbp1	17410	-0.240	-0.4768	No
72	Rad51d	Rad51d	17560	-0.249	-0.4763	No
73	Ccna2	Ccna2	17693	-0.255	-0.4750	No
74	Rpa2	Rpa2	18494	-0.294	-0.5009	No
75	Bard1	Bard1	18586	-0.299	-0.4966	No
76	Pold1	Pold1	19145	-0.331	-0.5112	Yes
77	Rad17	Rad17	19197	-0.334	-0.5042	Yes
78	Fen1	Fen1	19433	-0.350	-0.5046	Yes
79	Firrm	Firrm	19738	-0.372	-0.5074	Yes
80	Rad51b	Rad51b	19809	-0.377	-0.5000	Yes
81	H2bc22	H2bc22	19944	-0.388	-0.4951	Yes
82	Gen1	Gen1	20025	-0.394	-0.4877	Yes
83	Rfc3	Rfc3	20047	-0.396	-0.4777	Yes
84	Mdc1	Mdc1	20214	-0.411	-0.4736	Yes
85	Babam2	Babam2	20247	-0.414	-0.4636	Yes
86	Polh	Polh	20297	-0.419	-0.4542	Yes
87	Pcna	Pcna	20324	-0.421	-0.4437	Yes
88	Dna2	Dna2	20542	-0.443	-0.4408	Yes
89	Rfc5	Rfc5	20606	-0.450	-0.4311	Yes
90	Blm	Blm	20616	-0.451	-0.4191	Yes
91	Brca1	Brca1	20642	-0.453	-0.4078	Yes
92	Timeless	Timeless	20659	-0.456	-0.3960	Yes
93	Pole	Pole	20661	-0.456	-0.3835	Yes
94	H4c4	H4c4	20799	-0.470	-0.3764	Yes
95	Abraxas1	Abraxas1	20826	-0.473	-0.3646	Yes
96	Tipin	Tipin	20903	-0.483	-0.3546	Yes
97	Eme1	Eme1	20917	-0.485	-0.3418	Yes
98	H4c14	H4c14	20944	-0.487	-0.3296	Yes
99	Rad51c	Rad51c	21217	-0.519	-0.3269	Yes
100	Fignl1	Fignl1	21302	-0.533	-0.3159	Yes
101	Clspn	Clspn	21535	-0.567	-0.3102	Yes
102	Spidr	Spidr	21558	-0.569	-0.2956	Yes
103	Rmi2	Rmi2	21755	-0.604	-0.2873	Yes
104	Exo1	Exo1	21832	-0.620	-0.2736	Yes
105	Pold2	Pold2	21950	-0.643	-0.2609	Yes
106	H2bc9	H2bc9	21990	-0.652	-0.2448	Yes
107	Chek1	Chek1	22334	-0.739	-0.2391	Yes
108	Rfc4	Rfc4	22548	-0.808	-0.2260	Yes
109	H2bc8	H2bc8	22616	-0.834	-0.2060	Yes
110	Polq	Polq	22788	-0.913	-0.1882	Yes
111	H4c11	H4c11	22862	-0.951	-0.1653	Yes
112	H4c8	H4c8	22866	-0.953	-0.1393	Yes
113	Rad51	Rad51	22908	-0.973	-0.1144	Yes
114	H4c9	H4c9	22911	-0.975	-0.0877	Yes
115	H2bc4	H2bc4	23076	-1.092	-0.0648	Yes
116	H2bc6	H2bc6	23434	-1.594	-0.0362	Yes
117	H2bc3	H2bc3	23451	-1.655	0.0084	Yes

Fig 2: REACTOME_HOMOLOGY_DIRECTED_REPAIR   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_HOMOLOGY_DIRECTED_REPAIR: Random ES distribution   
Gene set null distribution of ES for REACTOME_HOMOLOGY_DIRECTED_REPAIR