Details for gene set REACTOME_NEDDYLATION[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WTandHET.KO_vs_WTandHET.cls#WT_versus_KO
Phenotype	KO_vs_WTandHET.cls#WT_versus_KO
Upregulated in class	WT
GeneSet	REACTOME_NEDDYLATION
Enrichment Score (ES)	0.24540052
Normalized Enrichment Score (NES)	1.6617323
Nominal p-value	0.0
FDR q-value	0.31091532
FWER p-Value	0.739

Fig 1: Enrichment plot: REACTOME_NEDDYLATION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Kbtbd13	Kbtbd13	71	2.584	0.0396	Yes
2	Asb18	Asb18	89	2.491	0.0800	Yes
3	Fbxw7	Fbxw7	324	1.622	0.0968	Yes
4	Asb14	Asb14	470	1.373	0.1133	Yes
5	Ankrd9	Ankrd9	526	1.316	0.1327	Yes
6	Klhl11	Klhl11	684	1.143	0.1448	Yes
7	Fbxo21	Fbxo21	693	1.137	0.1633	Yes
8	Asb16	Asb16	918	0.970	0.1697	Yes
9	Fbxo9	Fbxo9	925	0.966	0.1854	Yes
10	Fbxo31	Fbxo31	1192	0.833	0.1878	Yes
11	Btbd6	Btbd6	1204	0.830	0.2010	Yes
12	Spsb3	Spsb3	1210	0.827	0.2144	Yes
13	Fbxo10	Fbxo10	1687	0.681	0.2054	Yes
14	Klhl21	Klhl21	1777	0.658	0.2124	Yes
15	Wdtc1	Wdtc1	1919	0.627	0.2168	Yes
16	Asb12	Asb12	2246	0.571	0.2123	Yes
17	Cish	Cish	2313	0.559	0.2187	Yes
18	Dcaf11	Dcaf11	2321	0.557	0.2276	Yes
19	Epas1	Epas1	2487	0.525	0.2292	Yes
20	Uba52	Uba52	2497	0.523	0.2375	Yes
21	Fbxo32	Fbxo32	2671	0.496	0.2383	Yes
22	Klhl3	Klhl3	2695	0.492	0.2454	Yes
23	Btbd1	Btbd1	3383	0.413	0.2229	No
24	Fbxl20	Fbxl20	3473	0.405	0.2258	No
25	Fbxo44	Fbxo44	3506	0.402	0.2311	No
26	Ube2f	Ube2f	3715	0.383	0.2285	No
27	Dcun1d2	Dcun1d2	4545	0.315	0.1984	No
28	Dcaf10	Dcaf10	4868	0.291	0.1894	No
29	Ubxn7	Ubxn7	4967	0.284	0.1899	No
30	Klhl2	Klhl2	4974	0.283	0.1944	No
31	Fem1b	Fem1b	5214	0.268	0.1886	No
32	Fbxl3	Fbxl3	5240	0.266	0.1919	No
33	Lmo7	Lmo7	5491	0.249	0.1854	No
34	Keap1	Keap1	5712	0.237	0.1799	No
35	Fbxw5	Fbxw5	5787	0.233	0.1806	No
36	Fbxl5	Fbxl5	5813	0.232	0.1833	No
37	Cul4a	Cul4a	5854	0.230	0.1854	No
38	Gps1	Gps1	5931	0.225	0.1859	No
39	Nploc4	Nploc4	5934	0.225	0.1895	No
40	Dcun1d5	Dcun1d5	6078	0.219	0.1870	No
41	Ube2d1	Ube2d1	6179	0.213	0.1863	No
42	Ubb	Ubb	6345	0.205	0.1826	No
43	Fbxo27	Fbxo27	6397	0.203	0.1838	No
44	Socs3	Socs3	6484	0.198	0.1834	No
45	Ube2d3	Ube2d3	6540	0.196	0.1843	No
46	Dcaf6	Dcaf6	6602	0.193	0.1849	No
47	Fbxw2	Fbxw2	6792	0.183	0.1798	No
48	Ubc	Ubc	6804	0.183	0.1824	No
49	Socs6	Socs6	6870	0.180	0.1826	No
50	Fbxw4	Fbxw4	6875	0.180	0.1854	No
51	Fbxw11	Fbxw11	6926	0.177	0.1862	No
52	Dcaf4	Dcaf4	7100	0.168	0.1816	No
53	Lrrc41	Lrrc41	7113	0.168	0.1838	No
54	Cul2	Cul2	7203	0.164	0.1828	No
55	Rbbp5	Rbbp5	7287	0.160	0.1819	No
56	Fbxo41	Fbxo41	7314	0.159	0.1834	No
57	Adrm1	Adrm1	7431	0.154	0.1810	No
58	Dcaf7	Dcaf7	7674	0.143	0.1730	No
59	Ercc8	Ercc8	7971	0.129	0.1625	No
60	Klhl5	Klhl5	8035	0.126	0.1619	No
61	Vcp	Vcp	8192	0.119	0.1572	No
62	Cul3	Cul3	8255	0.116	0.1565	No
63	Uba52rt	Uba52rt	8363	0.113	0.1538	No
64	Asb6	Asb6	8390	0.112	0.1545	No
65	Eloc	Eloc	8420	0.110	0.1551	No
66	Psmb6	Psmb6	8529	0.106	0.1522	No
67	Rbx1	Rbx1	8538	0.106	0.1536	No
68	Fbxo11	Fbxo11	8844	0.094	0.1422	No
69	Asb7	Asb7	8920	0.091	0.1405	No
70	Wdr5	Wdr5	8959	0.090	0.1403	No
71	Gan	Gan	8997	0.089	0.1402	No
72	Commd7	Commd7	9074	0.085	0.1384	No
73	Spsb1	Spsb1	9259	0.079	0.1318	No
74	Fbxl14	Fbxl14	9274	0.078	0.1325	No
75	Nae1	Nae1	9404	0.073	0.1282	No
76	Asb5	Asb5	9407	0.073	0.1293	No
77	Commd1	Commd1	9523	0.068	0.1256	No
78	Fbxl16	Fbxl16	9668	0.061	0.1204	No
79	Dcaf5	Dcaf5	9697	0.061	0.1202	No
80	Nedd8	Nedd8	9861	0.054	0.1142	No
81	Psmd3	Psmd3	9872	0.054	0.1146	No
82	Commd10	Commd10	9910	0.052	0.1139	No
83	Commd6	Commd6	9923	0.052	0.1143	No
84	Commd4	Commd4	9976	0.050	0.1129	No
85	Psmd1	Psmd1	10060	0.047	0.1101	No
86	Rnf7	Rnf7	10331	0.037	0.0992	No
87	Fbxw8	Fbxw8	10455	0.032	0.0945	No
88	Rbbp7	Rbbp7	10693	0.024	0.0848	No
89	Mul1	Mul1	10754	0.022	0.0826	No
90	Senp8	Senp8	10816	0.020	0.0803	No
91	Klhl42	Klhl42	10961	0.015	0.0744	No
92	Psmb4	Psmb4	11008	0.014	0.0727	No
93	Dcaf8	Dcaf8	11099	0.011	0.0690	No
94	Fbxl18	Fbxl18	11195	0.007	0.0651	No
95	Asb1	Asb1	11220	0.007	0.0642	No
96	Commd5	Commd5	11271	0.005	0.0621	No
97	Cul1	Cul1	11389	0.001	0.0572	No
98	Psmb3	Psmb3	11401	0.000	0.0567	No
99	Klhl20	Klhl20	11402	-0.000	0.0567	No
100	Ube2d2a	Ube2d2a	11412	-0.000	0.0563	No
101	Psmd7	Psmd7	11431	-0.001	0.0556	No
102	Psmc3	Psmc3	11603	-0.007	0.0484	No
103	Klhl25	Klhl25	11613	-0.007	0.0481	No
104	Cops7b	Cops7b	11808	-0.014	0.0401	No
105	Wsb1	Wsb1	11856	-0.016	0.0383	No
106	Nub1	Nub1	11946	-0.019	0.0349	No
107	Cops6	Cops6	12006	-0.021	0.0327	No
108	Commd9	Commd9	12066	-0.023	0.0306	No
109	Commd2	Commd2	12188	-0.027	0.0258	No
110	Psmc6	Psmc6	12222	-0.028	0.0249	No
111	Ddb2	Ddb2	12475	-0.037	0.0148	No
112	Psmb5	Psmb5	12516	-0.039	0.0137	No
113	Klhl22	Klhl22	12574	-0.041	0.0119	No
114	Fbxl15	Fbxl15	12604	-0.042	0.0114	No
115	Skp1	Skp1	12692	-0.046	0.0084	No
116	Psmc2	Psmc2	12801	-0.049	0.0046	No
117	Fbxl12	Fbxl12	12809	-0.050	0.0052	No
118	Psma7	Psma7	12887	-0.052	0.0028	No
119	Nfe2l2	Nfe2l2	12936	-0.054	0.0016	No
120	Psmd11	Psmd11	12988	-0.056	0.0003	No
121	Fbxl13	Fbxl13	12999	-0.056	0.0008	No
122	Psmd6	Psmd6	13028	-0.057	0.0006	No
123	Cop1	Cop1	13098	-0.060	-0.0014	No
124	Psmc5	Psmc5	13151	-0.062	-0.0026	No
125	Kbtbd7	Kbtbd7	13179	-0.063	-0.0027	No
126	Asb4	Asb4	13200	-0.064	-0.0025	No
127	Psma2	Psma2	13246	-0.066	-0.0033	No
128	Klhl13	Klhl13	13313	-0.068	-0.0050	No
129	Cops7a	Cops7a	13402	-0.071	-0.0076	No
130	Psma3	Psma3	13458	-0.073	-0.0087	No
131	Ufd1	Ufd1	13493	-0.074	-0.0090	No
132	Cops3	Cops3	13497	-0.075	-0.0079	No
133	Psmd13	Psmd13	13505	-0.075	-0.0069	No
134	Elob	Elob	13533	-0.076	-0.0068	No
135	Fbxo22	Fbxo22	13690	-0.082	-0.0121	No
136	Fbxw9	Fbxw9	13780	-0.085	-0.0145	No
137	Psmc4	Psmc4	13831	-0.087	-0.0152	No
138	Fbxl4	Fbxl4	14231	-0.104	-0.0305	No
139	Fbxl21	Fbxl21	14293	-0.106	-0.0314	No
140	Commd8	Commd8	14555	-0.117	-0.0406	No
141	Psmd12	Psmd12	14791	-0.127	-0.0485	No
142	Fbxl8	Fbxl8	15203	-0.143	-0.0637	No
143	Cops4	Cops4	15275	-0.146	-0.0643	No
144	Psmb1	Psmb1	15331	-0.148	-0.0642	No
145	Socs5	Socs5	15490	-0.154	-0.0684	No
146	Fem1a	Fem1a	15496	-0.154	-0.0661	No
147	Fem1c	Fem1c	15507	-0.155	-0.0640	No
148	Rps27a	Rps27a	15542	-0.156	-0.0628	No
149	Dcaf13	Dcaf13	15603	-0.158	-0.0628	No
150	Ddb1	Ddb1	15799	-0.167	-0.0683	No
151	Cops8	Cops8	15905	-0.171	-0.0700	No
152	Psma4	Psma4	16046	-0.177	-0.0731	No
153	Vhl	Vhl	16148	-0.181	-0.0744	No
154	Uba3	Uba3	16218	-0.184	-0.0743	No
155	Fbxl7	Fbxl7	16219	-0.184	-0.0712	No
156	Wsb2	Wsb2	16248	-0.185	-0.0694	No
157	Psmb7	Psmb7	16359	-0.190	-0.0709	No
158	Cops5	Cops5	16700	-0.207	-0.0820	No
159	Dda1	Dda1	16761	-0.210	-0.0811	No
160	Psmc1	Psmc1	16835	-0.213	-0.0807	No
161	Dcaf17	Dcaf17	16857	-0.214	-0.0781	No
162	Fbxo7	Fbxo7	17004	-0.222	-0.0806	No
163	Dcun1d4	Dcun1d4	17024	-0.223	-0.0778	No
164	Cul4b	Cul4b	17044	-0.223	-0.0749	No
165	Psmb2	Psmb2	17120	-0.227	-0.0743	No
166	Cops2	Cops2	17172	-0.229	-0.0727	No
167	Dcun1d1	Dcun1d1	17177	-0.230	-0.0691	No
168	Dcun1d3	Dcun1d3	17309	-0.236	-0.0708	No
169	Psmd8	Psmd8	17312	-0.236	-0.0670	No
170	Ube2m	Ube2m	17326	-0.236	-0.0636	No
171	Psma1	Psma1	17500	-0.245	-0.0670	No
172	Cand1	Cand1	17531	-0.247	-0.0642	No
173	Psmd14	Psmd14	17703	-0.255	-0.0672	No
174	Psma5	Psma5	17770	-0.259	-0.0658	No
175	Psmd2	Psmd2	17847	-0.262	-0.0647	No
176	Ccdc22	Ccdc22	17865	-0.263	-0.0611	No
177	Socs2	Socs2	17989	-0.269	-0.0619	No
178	Psma6	Psma6	18071	-0.273	-0.0608	No
179	Fbxw17	Fbxw17	18254	-0.282	-0.0639	No
180	Hif1a	Hif1a	18276	-0.284	-0.0601	No
181	Tulp4	Tulp4	18900	-0.316	-0.0815	No
182	Kctd6	Kctd6	18952	-0.319	-0.0784	No
183	Skp2	Skp2	18957	-0.319	-0.0733	No
184	Spsb2	Spsb2	19966	-0.389	-0.1099	No
185	Fbxl19	Fbxl19	20114	-0.401	-0.1095	No
186	Ccnf	Ccnf	20243	-0.413	-0.1082	No
187	Neurl2	Neurl2	20558	-0.445	-0.1142	No
188	Fbxo4	Fbxo4	20709	-0.461	-0.1130	No
189	Asb13	Asb13	20872	-0.480	-0.1120	No
190	Klhl9	Klhl9	20886	-0.481	-0.1046	No
191	Uchl3	Uchl3	21004	-0.494	-0.1015	No
192	Fbxo6	Fbxo6	21378	-0.544	-0.1084	No
193	Asb10	Asb10	21399	-0.548	-0.1002	No
194	Commd3	Commd3	21592	-0.575	-0.0989	No
195	Fbxo30	Fbxo30	21604	-0.577	-0.0899	No
196	Fbxo17	Fbxo17	21629	-0.581	-0.0813	No
197	Asb8	Asb8	21925	-0.639	-0.0833	No
198	Kctd7	Kctd7	22053	-0.666	-0.0777	No
199	Dtl	Dtl	22200	-0.703	-0.0724	No
200	Klhl41	Klhl41	22240	-0.713	-0.0623	No
201	Lrr1	Lrr1	22405	-0.759	-0.0567	No
202	Kbtbd8	Kbtbd8	22573	-0.818	-0.0504	No
203	Asb11	Asb11	22833	-0.937	-0.0459	No
204	Spsb4	Spsb4	22907	-0.973	-0.0330	No
205	Fbxw10	Fbxw10	23074	-1.092	-0.0221	No
206	Fbxo40	Fbxo40	23261	-1.259	-0.0092	No
207	Hif3a	Hif3a	23427	-1.558	0.0095	No

Fig 2: REACTOME_NEDDYLATION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_NEDDYLATION: Random ES distribution   
Gene set null distribution of ES for REACTOME_NEDDYLATION