Details for gene set WP_AMINO_ACID_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WTandHET.KO_vs_WTandHET.cls#WT_versus_KO
Phenotype	KO_vs_WTandHET.cls#WT_versus_KO
Upregulated in class	WT
GeneSet	WP_AMINO_ACID_METABOLISM
Enrichment Score (ES)	0.4107357
Normalized Enrichment Score (NES)	1.4417
Nominal p-value	0.059063137
FDR q-value	0.37329265
FWER p-Value	0.797

Fig 1: Enrichment plot: WP_AMINO_ACID_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Hmgcs2	Hmgcs2	27	3.152	0.0771	Yes
2	Acss1	Acss1	191	1.983	0.1194	Yes
3	Gpt2	Gpt2	369	1.536	0.1500	Yes
4	Dbh	Dbh	449	1.405	0.1816	Yes
5	Ldha	Ldha	504	1.337	0.2124	Yes
6	P4ha2	P4ha2	575	1.258	0.2407	Yes
7	Ppm1l	Ppm1l	700	1.131	0.2635	Yes
8	Prodh	Prodh	883	0.996	0.2805	Yes
9	Ehhadh	Ehhadh	1189	0.833	0.2883	Yes
10	Ftcd	Ftcd	1303	0.789	0.3030	Yes
11	Pdha1	Pdha1	1572	0.711	0.3093	Yes
12	Hnmt	Hnmt	1655	0.689	0.3229	Yes
13	Pdk4	Pdk4	1669	0.686	0.3394	Yes
14	Hadh	Hadh	1807	0.650	0.3497	Yes
15	Mpst	Mpst	2205	0.578	0.3472	Yes
16	Mdh2	Mdh2	2299	0.562	0.3572	Yes
17	Hdc	Hdc	2351	0.550	0.3687	Yes
18	Suclg1	Suclg1	2551	0.516	0.3731	Yes
19	Pnmt	Pnmt	2699	0.492	0.3791	Yes
20	Mccc1	Mccc1	2783	0.480	0.3875	Yes
21	Auh	Auh	2866	0.468	0.3956	Yes
22	Cs	Cs	2877	0.466	0.4067	Yes
23	Sms	Sms	3045	0.447	0.4107	Yes
24	Arg1	Arg1	3462	0.406	0.4032	No
25	Dld	Dld	3822	0.373	0.3972	No
26	Sdha	Sdha	3860	0.371	0.4048	No
27	Got1	Got1	4054	0.353	0.4054	No
28	Pdhx	Pdhx	4292	0.335	0.4037	No
29	Hmgcl	Hmgcl	4567	0.313	0.3998	No
30	Acadm	Acadm	4651	0.307	0.4039	No
31	Ogdh	Ogdh	5036	0.280	0.3945	No
32	Mmut	Mmut	6596	0.193	0.3332	No
33	Fah	Fah	6900	0.178	0.3247	No
34	Mars2	Mars2	7040	0.171	0.3231	No
35	Acaa1a	Acaa1a	7956	0.130	0.2875	No
36	Glud1	Glud1	8009	0.127	0.2885	No
37	Mdh1	Mdh1	8090	0.124	0.2881	No
38	Sdhd	Sdhd	8760	0.097	0.2621	No
39	Ddc	Ddc	8786	0.096	0.2635	No
40	Gclm	Gclm	9034	0.087	0.2551	No
41	Hal	Hal	9219	0.080	0.2493	No
42	Dlst	Dlst	9626	0.063	0.2337	No
43	Hibch	Hibch	9762	0.058	0.2294	No
44	Aoc3	Aoc3	10974	0.015	0.1784	No
45	Adh1	Adh1	11423	-0.001	0.1594	No
46	Oat	Oat	11804	-0.014	0.1436	No
47	Acly	Acly	11967	-0.020	0.1372	No
48	Got2	Got2	12273	-0.030	0.1250	No
49	Wars1	Wars1	12353	-0.033	0.1225	No
50	Iars1	Iars1	12441	-0.036	0.1197	No
51	Gsr	Gsr	13114	-0.061	0.0927	No
52	Pkm	Pkm	13591	-0.078	0.0744	No
53	Aldh1a1	Aldh1a1	14168	-0.101	0.0525	No
54	Farsb	Farsb	14466	-0.113	0.0427	No
55	Aldh7a1	Aldh7a1	14824	-0.128	0.0307	No
56	Idh1	Idh1	15607	-0.159	0.0015	No
57	Fh1	Fh1	15707	-0.163	0.0013	No
58	Maoa	Maoa	15745	-0.165	0.0038	No
59	Aco2	Aco2	15908	-0.171	0.0012	No
60	Aldh18a1	Aldh18a1	16960	-0.219	-0.0379	No
61	Adh5	Adh5	16980	-0.221	-0.0333	No
62	Gls	Gls	17014	-0.222	-0.0291	No
63	Bcat1	Bcat1	17875	-0.264	-0.0591	No
64	Ass1	Ass1	18294	-0.285	-0.0698	No
65	Eprs1	Eprs1	18378	-0.288	-0.0661	No
66	Hibadh	Hibadh	18537	-0.296	-0.0655	No
67	Pcx	Pcx	18818	-0.311	-0.0697	No
68	Cth	Cth	19037	-0.324	-0.0709	No
69	Asl	Asl	19296	-0.340	-0.0734	No
70	Vars1	Vars1	19405	-0.348	-0.0693	No
71	Cbs	Cbs	19625	-0.364	-0.0696	No
72	Cad	Cad	20160	-0.405	-0.0822	No
73	Tat	Tat	20309	-0.420	-0.0780	No
74	Rars1	Rars1	20372	-0.426	-0.0701	No
75	Odc1	Odc1	21503	-0.562	-0.1041	No
76	Srm	Srm	22115	-0.683	-0.1131	No
77	Gss	Gss	22156	-0.692	-0.0976	No
78	Gsta4	Gsta4	22206	-0.704	-0.0822	No
79	Pycr1	Pycr1	22956	-1.000	-0.0891	No
80	Tpo	Tpo	22978	-1.014	-0.0649	No
81	Asns	Asns	23454	-1.662	-0.0438	No
82	Glul	Glul	23546	-2.096	0.0044	No

Fig 2: WP_AMINO_ACID_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: WP_AMINO_ACID_METABOLISM: Random ES distribution   
Gene set null distribution of ES for WP_AMINO_ACID_METABOLISM