Details for gene set WP_ESC_PLURIPOTENCY_PATHWAYS[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WTandHET.KO_vs_WTandHET.cls#WT_versus_KO
Phenotype	KO_vs_WTandHET.cls#WT_versus_KO
Upregulated in class	WT
GeneSet	WP_ESC_PLURIPOTENCY_PATHWAYS
Enrichment Score (ES)	0.38818347
Normalized Enrichment Score (NES)	1.4809384
Nominal p-value	0.032388665
FDR q-value	0.39795792
FWER p-Value	0.729

Fig 1: Enrichment plot: WP_ESC_PLURIPOTENCY_PATHWAYS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Mapk4	Mapk4	50	2.779	0.0599	Yes
2	Smad9	Smad9	203	1.937	0.0967	Yes
3	Egf	Egf	213	1.913	0.1391	Yes
4	Fgf18	Fgf18	400	1.474	0.1641	Yes
5	Fgf6	Fgf6	465	1.380	0.1922	Yes
6	Fzd2	Fzd2	484	1.356	0.2217	Yes
7	Wnt10b	Wnt10b	606	1.214	0.2437	Yes
8	Bmpr1b	Bmpr1b	860	1.018	0.2557	Yes
9	Fgf13	Fgf13	987	0.930	0.2711	Yes
10	Wnt5b	Wnt5b	1187	0.834	0.2813	Yes
11	Fgf14	Fgf14	1241	0.811	0.2971	Yes
12	Fzd9	Fzd9	1258	0.807	0.3145	Yes
13	Fzd3	Fzd3	1449	0.745	0.3231	Yes
14	Akt1	Akt1	1613	0.701	0.3318	Yes
15	Wnt4	Wnt4	1688	0.680	0.3438	Yes
16	Fzd6	Fzd6	1943	0.623	0.3470	Yes
17	Akt2	Akt2	1944	0.623	0.3609	Yes
18	Fzd8	Fzd8	1993	0.612	0.3725	Yes
19	Acvr1	Acvr1	2094	0.595	0.3816	Yes
20	Nog	Nog	2370	0.547	0.3821	Yes
21	Jun	Jun	2502	0.522	0.3882	Yes
22	Map2k3	Map2k3	3009	0.450	0.3767	No
23	Smad6	Smad6	3391	0.412	0.3698	No
24	Fgf2	Fgf2	3550	0.398	0.3720	No
25	Pik3r2	Pik3r2	4184	0.343	0.3527	No
26	Lifr	Lifr	4241	0.338	0.3579	No
27	Lrp6	Lrp6	4326	0.332	0.3618	No
28	Dvl3	Dvl3	4362	0.330	0.3677	No
29	Mapk12	Mapk12	4729	0.301	0.3588	No
30	Mtor	Mtor	4779	0.298	0.3634	No
31	Araf	Araf	5027	0.280	0.3592	No
32	Fgf1	Fgf1	5296	0.262	0.3536	No
33	Axin1	Axin1	5405	0.255	0.3547	No
34	Wnt5a	Wnt5a	5496	0.249	0.3565	No
35	Raf1	Raf1	5546	0.246	0.3599	No
36	Il6st	Il6st	5711	0.237	0.3582	No
37	Pdgfb	Pdgfb	5850	0.230	0.3575	No
38	Ctnnb1	Ctnnb1	5852	0.230	0.3626	No
39	Sos1	Sos1	6026	0.221	0.3602	No
40	Smad5	Smad5	6236	0.210	0.3560	No
41	Map2k5	Map2k5	6338	0.205	0.3563	No
42	Stat3	Stat3	6366	0.204	0.3597	No
43	Jak1	Jak1	6461	0.200	0.3602	No
44	Gab1	Gab1	6867	0.180	0.3470	No
45	Smad7	Smad7	6882	0.180	0.3504	No
46	Gsk3b	Gsk3b	7312	0.159	0.3357	No
47	Bmpr2	Bmpr2	7395	0.155	0.3357	No
48	Map2k1	Map2k1	7527	0.150	0.3335	No
49	Mapk6	Mapk6	7535	0.150	0.3366	No
50	Mdm2	Mdm2	8497	0.107	0.2981	No
51	Smad4	Smad4	8595	0.104	0.2963	No
52	Mapk1	Mapk1	8711	0.099	0.2937	No
53	Bmp4	Bmp4	8903	0.092	0.2876	No
54	Elk1	Elk1	9008	0.088	0.2852	No
55	Fgf9	Fgf9	9704	0.060	0.2570	No
56	Dvl2	Dvl2	10082	0.046	0.2420	No
57	Hras	Hras	10115	0.045	0.2417	No
58	Pdgfra	Pdgfra	10278	0.039	0.2357	No
59	Apc	Apc	10372	0.036	0.2325	No
60	Mapk7	Mapk7	10578	0.028	0.2244	No
61	Pik3cd	Pik3cd	10621	0.027	0.2232	No
62	Ptpn11	Ptpn11	11110	0.010	0.2027	No
63	Dvl1	Dvl1	11437	-0.001	0.1889	No
64	Grb2	Grb2	11511	-0.004	0.1859	No
65	Map2k2	Map2k2	12014	-0.021	0.1651	No
66	Bmpr1a	Bmpr1a	12152	-0.026	0.1598	No
67	Braf	Braf	12225	-0.029	0.1574	No
68	Pten	Pten	12340	-0.032	0.1533	No
69	Selenop	Selenop	12440	-0.036	0.1499	No
70	Smad1	Smad1	12781	-0.049	0.1366	No
71	Fzd5	Fzd5	13174	-0.062	0.1213	No
72	Akt3	Akt3	13704	-0.082	0.1007	No
73	Actr2	Actr2	14474	-0.114	0.0706	No
74	Fgf10	Fgf10	14622	-0.119	0.0670	No
75	Wnt2	Wnt2	14627	-0.119	0.0695	No
76	Fzd1	Fzd1	14752	-0.125	0.0670	No
77	Egfr	Egfr	14996	-0.135	0.0597	No
78	Fzd4	Fzd4	15772	-0.166	0.0305	No
79	Wnt6	Wnt6	15924	-0.172	0.0279	No
80	Fzd7	Fzd7	16029	-0.176	0.0274	No
81	Fgfr3	Fgfr3	16270	-0.187	0.0214	No
82	Pdgfrb	Pdgfrb	16772	-0.211	0.0048	No
83	Pdgfa	Pdgfa	17021	-0.223	-0.0007	No
84	Wnt9b	Wnt9b	17807	-0.261	-0.0283	No
85	Hnf1a	Hnf1a	18286	-0.284	-0.0422	No
86	Fgfr1	Fgfr1	18385	-0.288	-0.0399	No
87	Wnt7b	Wnt7b	18417	-0.290	-0.0348	No
88	Wnt7a	Wnt7a	18635	-0.301	-0.0373	No
89	Wnt2b	Wnt2b	18744	-0.306	-0.0350	No
90	Fos	Fos	18750	-0.307	-0.0284	No
91	Wnt11	Wnt11	18852	-0.313	-0.0257	No
92	Fgfr4	Fgfr4	19016	-0.322	-0.0254	No
93	Fgfr2	Fgfr2	19450	-0.351	-0.0359	No
94	Lrp5	Lrp5	20078	-0.399	-0.0536	No
95	Fgf17	Fgf17	21584	-0.575	-0.1047	No
96	Lif	Lif	22370	-0.749	-0.1213	No
97	Fgf7	Fgf7	22423	-0.764	-0.1065	No
98	Map2k6	Map2k6	22945	-0.993	-0.1064	No
99	Myc	Myc	22951	-0.997	-0.0844	No
100	Wnt16	Wnt16	23086	-1.099	-0.0655	No
101	Fgf12	Fgf12	23464	-1.706	-0.0434	No
102	Fgf16	Fgf16	23573	-2.294	0.0032	No

Fig 2: WP_ESC_PLURIPOTENCY_PATHWAYS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: WP_ESC_PLURIPOTENCY_PATHWAYS: Random ES distribution   
Gene set null distribution of ES for WP_ESC_PLURIPOTENCY_PATHWAYS