Details for gene set WP_PURINE_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	KO_vs_WTandHET.KO_vs_WTandHET.cls#WT_versus_KO
Phenotype	KO_vs_WTandHET.cls#WT_versus_KO
Upregulated in class	KO
GeneSet	WP_PURINE_METABOLISM
Enrichment Score (ES)	-0.26539382
Normalized Enrichment Score (NES)	-1.2026242
Nominal p-value	0.19681908
FDR q-value	0.6169736
FWER p-Value	0.972

Fig 1: Enrichment plot: WP_PURINE_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Ampd3	Ampd3	332	1.603	0.0148	No
2	Adcy1	Adcy1	406	1.464	0.0382	No
3	Entpd5	Entpd5	515	1.327	0.0576	No
4	Pde7b	Pde7b	649	1.174	0.0731	No
5	Pde4a	Pde4a	688	1.139	0.0921	No
6	Adcy5	Adcy5	936	0.960	0.0989	No
7	Pde1c	Pde1c	971	0.942	0.1145	No
8	Pde8b	Pde8b	1153	0.847	0.1221	No
9	Nt5c1a	Nt5c1a	1358	0.773	0.1274	No
10	Adcy9	Adcy9	1539	0.720	0.1328	No
11	Ak1	Ak1	1566	0.712	0.1445	No
12	Urah	Urah	1830	0.644	0.1450	No
13	Adcy6	Adcy6	2080	0.596	0.1452	No
14	Polr2l	Polr2l	2213	0.577	0.1500	No
15	Entpd2	Entpd2	2366	0.547	0.1534	No
16	Polr1a	Polr1a	2447	0.531	0.1596	No
17	Nme3	Nme3	2508	0.521	0.1665	No
18	Dguok	Dguok	2786	0.480	0.1633	No
19	Gda	Gda	3099	0.441	0.1580	No
20	Pde4d	Pde4d	3185	0.432	0.1622	No
21	Xdh	Xdh	3390	0.412	0.1610	No
22	Adprm	Adprm	3813	0.374	0.1498	No
23	Ampd1	Ampd1	4903	0.288	0.1087	No
24	Pde9a	Pde9a	5256	0.265	0.0985	No
25	Polr1e	Polr1e	5390	0.255	0.0974	No
26	Nme5	Nme5	5439	0.253	0.0999	No
27	Pde10a	Pde10a	5466	0.251	0.1034	No
28	Ppat	Ppat	5603	0.243	0.1020	No
29	Polr2j	Polr2j	5756	0.234	0.0997	No
30	Ak6	Ak6	6031	0.221	0.0921	No
31	Pde4c	Pde4c	6125	0.216	0.0920	No
32	Polr3gl	Polr3gl	6158	0.214	0.0945	No
33	Ak4	Ak4	6265	0.209	0.0938	No
34	Npr1	Npr1	7023	0.172	0.0647	No
35	Gmps	Gmps	7024	0.172	0.0678	No
36	Gucy1b1	Gucy1b1	7763	0.138	0.0389	No
37	Gucy2e	Gucy2e	7865	0.134	0.0370	No
38	Gucy1a1	Gucy1a1	7977	0.129	0.0346	No
39	Papss1	Papss1	8350	0.113	0.0208	No
40	Pde7a	Pde7a	8505	0.107	0.0162	No
41	Pde1a	Pde1a	8937	0.090	-0.0005	No
42	Pde1b	Pde1b	9043	0.087	-0.0034	No
43	Cant1	Cant1	9204	0.081	-0.0088	No
44	Polr2f	Polr2f	9336	0.075	-0.0130	No
45	Polr3b	Polr3b	9359	0.074	-0.0126	No
46	Npr2	Npr2	9545	0.067	-0.0192	No
47	Polr1d	Polr1d	9657	0.062	-0.0228	No
48	Polr2i	Polr2i	9955	0.051	-0.0346	No
49	Nt5c2	Nt5c2	10104	0.045	-0.0400	No
50	Polr3a	Polr3a	10640	0.026	-0.0623	No
51	Nme2	Nme2	10723	0.023	-0.0654	No
52	Polr3f	Polr3f	10824	0.020	-0.0693	No
53	Polr3c	Polr3c	10915	0.017	-0.0728	No
54	Nme6	Nme6	10960	0.015	-0.0744	No
55	Pde4b	Pde4b	11026	0.013	-0.0769	No
56	Adcy4	Adcy4	11036	0.013	-0.0771	No
57	Pola2	Pola2	11775	-0.013	-0.1083	No
58	Polr2c	Polr2c	11966	-0.020	-0.1160	No
59	Ampd2	Ampd2	12033	-0.022	-0.1184	No
60	Impdh2	Impdh2	12303	-0.031	-0.1293	No
61	Entpd1	Entpd1	12377	-0.033	-0.1318	No
62	Rrm2b	Rrm2b	12397	-0.034	-0.1320	No
63	Polr3d	Polr3d	12577	-0.041	-0.1389	No
64	Pgm2	Pgm2	12627	-0.043	-0.1402	No
65	Hprt1	Hprt1	12843	-0.051	-0.1484	No
66	Itpa	Itpa	12945	-0.054	-0.1517	No
67	Polr2d	Polr2d	12954	-0.055	-0.1511	No
68	Polr2b	Polr2b	13015	-0.057	-0.1526	No
69	Polr3e	Polr3e	13022	-0.057	-0.1518	No
70	Pde5a	Pde5a	13048	-0.058	-0.1519	No
71	Papss2	Papss2	13081	-0.059	-0.1522	No
72	Adcy3	Adcy3	13362	-0.069	-0.1628	No
73	Pkm	Pkm	13591	-0.078	-0.1711	No
74	Pnp	Pnp	13624	-0.079	-0.1710	No
75	Polr1h	Polr1h	13678	-0.081	-0.1718	No
76	Pole3	Pole3	13712	-0.082	-0.1717	No
77	Enpp3	Enpp3	14082	-0.097	-0.1857	No
78	Impdh1	Impdh1	14296	-0.107	-0.1928	No
79	Polr2e	Polr2e	14320	-0.107	-0.1919	No
80	Nt5c3	Nt5c3	14378	-0.110	-0.1923	No
81	Polr3h	Polr3h	14920	-0.132	-0.2130	No
82	Pole4	Pole4	14930	-0.132	-0.2109	No
83	Entpd6	Entpd6	14968	-0.133	-0.2101	No
84	Pold4	Pold4	15395	-0.150	-0.2255	No
85	Pde3b	Pde3b	15847	-0.169	-0.2417	No
86	Gmpr2	Gmpr2	15995	-0.175	-0.2448	No
87	Pde6d	Pde6d	15996	-0.175	-0.2416	No
88	Ak5	Ak5	16109	-0.180	-0.2431	No
89	Gucy1a2	Gucy1a2	16134	-0.181	-0.2409	No
90	Adss2	Adss2	16156	-0.182	-0.2385	No
91	Polr2a	Polr2a	16160	-0.182	-0.2353	No
92	Pde8a	Pde8a	16190	-0.183	-0.2333	No
93	Prps1	Prps1	16237	-0.185	-0.2319	No
94	Pold3	Pold3	16273	-0.187	-0.2300	No
95	Pole2	Pole2	16365	-0.191	-0.2304	No
96	Polr3k	Polr3k	16525	-0.199	-0.2336	No
97	Nudt9	Nudt9	16706	-0.207	-0.2375	No
98	Polr1c	Polr1c	16973	-0.220	-0.2449	No
99	Paics	Paics	17143	-0.228	-0.2479	No
100	Nudt5	Nudt5	17175	-0.230	-0.2451	No
101	Ak2	Ak2	17187	-0.230	-0.2414	No
102	Ak8	Ak8	17228	-0.232	-0.2389	No
103	Adcy7	Adcy7	17444	-0.242	-0.2437	No
104	Pklr	Pklr	17536	-0.248	-0.2431	No
105	Polr2h	Polr2h	17757	-0.259	-0.2478	No
106	Entpd3	Entpd3	17825	-0.261	-0.2459	No
107	Pnpt1	Pnpt1	18083	-0.273	-0.2519	No
108	Gmpr	Gmpr	18369	-0.288	-0.2588	No
109	Polr2g	Polr2g	18370	-0.288	-0.2536	No
110	Prps2	Prps2	18384	-0.288	-0.2490	No
111	Polr1b	Polr1b	18771	-0.308	-0.2598	Yes
112	Pgm1	Pgm1	18785	-0.308	-0.2548	Yes
113	Gart	Gart	18978	-0.320	-0.2572	Yes
114	Taf9	Taf9	19059	-0.325	-0.2547	Yes
115	Pold1	Pold1	19145	-0.331	-0.2524	Yes
116	Gucy2c	Gucy2c	19151	-0.331	-0.2466	Yes
117	Pnp2	Pnp2	19460	-0.352	-0.2533	Yes
118	Pde6g	Pde6g	19550	-0.358	-0.2506	Yes
119	Prune1	Prune1	19626	-0.364	-0.2473	Yes
120	Entpd8	Entpd8	19775	-0.374	-0.2468	Yes
121	Prps1l3	Prps1l3	19961	-0.389	-0.2476	Yes
122	Prim2	Prim2	20082	-0.399	-0.2455	Yes
123	Adk	Adk	20320	-0.421	-0.2480	Yes
124	Nme7	Nme7	20374	-0.426	-0.2426	Yes
125	Adsl	Adsl	20421	-0.431	-0.2367	Yes
126	Ada	Ada	20462	-0.435	-0.2306	Yes
127	Nt5m	Nt5m	20478	-0.437	-0.2233	Yes
128	Prim1	Prim1	20566	-0.446	-0.2189	Yes
129	Guk1	Guk1	20635	-0.453	-0.2137	Yes
130	Pole	Pole	20661	-0.456	-0.2065	Yes
131	Dck	Dck	20697	-0.458	-0.1997	Yes
132	Nudt2	Nudt2	20883	-0.481	-0.1989	Yes
133	Pola1	Pola1	20956	-0.488	-0.1931	Yes
134	Nudt16	Nudt16	21254	-0.526	-0.1962	Yes
135	Adcy2	Adcy2	21498	-0.561	-0.1964	Yes
136	Enpp1	Enpp1	21538	-0.567	-0.1878	Yes
137	Aprt	Aprt	21549	-0.568	-0.1780	Yes
138	Rrm1	Rrm1	21859	-0.625	-0.1799	Yes
139	Ak9	Ak9	21887	-0.631	-0.1696	Yes
140	Pold2	Pold2	21950	-0.643	-0.1606	Yes
141	Nt5c	Nt5c	21959	-0.644	-0.1493	Yes
142	Fhit	Fhit	22155	-0.692	-0.1451	Yes
143	Polr3g	Polr3g	22286	-0.726	-0.1375	Yes
144	Nme1	Nme1	22290	-0.728	-0.1245	Yes
145	Rrm2	Rrm2	22329	-0.737	-0.1128	Yes
146	Adss1	Adss1	22555	-0.811	-0.1077	Yes
147	Pde3a	Pde3a	22577	-0.820	-0.0938	Yes
148	Pfas	Pfas	22635	-0.843	-0.0810	Yes
149	Atic	Atic	22655	-0.853	-0.0664	Yes
150	Ak7	Ak7	22783	-0.912	-0.0553	Yes
151	Nt5e	Nt5e	23119	-1.124	-0.0492	Yes
152	Hddc3	Hddc3	23395	-1.495	-0.0339	Yes
153	Nme4	Nme4	23591	-2.472	0.0025	Yes

Fig 2: WP_PURINE_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: WP_PURINE_METABOLISM: Random ES distribution   
Gene set null distribution of ES for WP_PURINE_METABOLISM