Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #24hr_versus_0hr.class.cls #24hr_versus_0hr_repos |
| Phenotype | class.cls#24hr_versus_0hr_repos |
| Upregulated in class | 24hr |
| GeneSet | GHANDHI_DIRECT_IRRADIATION_UP |
| Enrichment Score (ES) | 0.45048097 |
| Normalized Enrichment Score (NES) | 1.821753 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.6288057 |
| FWER p-Value | 0.504 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 44 | 4.481 | 0.0381 | Yes |
| 2 | BLOC1S2 | BLOC1S2 Entrez, Source | biogenesis of lysosome-related organelles complex-1, subunit 2 | 93 | 4.319 | 0.0744 | Yes |
| 3 | CXCL3 | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 193 | 4.045 | 0.1045 | Yes |
| 4 | PTPRE | PTPRE Entrez, Source | protein tyrosine phosphatase, receptor type, E | 326 | 3.844 | 0.1303 | Yes |
| 5 | PLK3 | PLK3 Entrez, Source | polo-like kinase 3 (Drosophila) | 491 | 3.621 | 0.1518 | Yes |
| 6 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 606 | 3.483 | 0.1756 | Yes |
| 7 | ASCC3 | ASCC3 Entrez, Source | activating signal cointegrator 1 complex subunit 3 | 627 | 3.468 | 0.2061 | Yes |
| 8 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 679 | 3.420 | 0.2339 | Yes |
| 9 | TNFRSF10B | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 701 | 3.400 | 0.2637 | Yes |
| 10 | HSPA4L | HSPA4L Entrez, Source | heat shock 70kDa protein 4-like | 854 | 3.232 | 0.2824 | Yes |
| 11 | MDM2 | MDM2 Entrez, Source | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | 1046 | 3.022 | 0.2964 | Yes |
| 12 | SLC7A11 | SLC7A11 Entrez, Source | solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 | 1079 | 2.992 | 0.3217 | Yes |
| 13 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1200 | 2.898 | 0.3397 | Yes |
| 14 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 1266 | 2.836 | 0.3611 | Yes |
| 15 | LIF | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 1455 | 2.681 | 0.3722 | Yes |
| 16 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 1581 | 2.568 | 0.3868 | Yes |
| 17 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 1601 | 2.556 | 0.4089 | Yes |
| 18 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 1913 | 2.322 | 0.4078 | Yes |
| 19 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 2011 | 2.258 | 0.4216 | Yes |
| 20 | RELB | RELB Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) | 2237 | 2.086 | 0.4245 | Yes |
| 21 | GDF15 | GDF15 Entrez, Source | growth differentiation factor 15 | 2430 | 1.961 | 0.4286 | Yes |
| 22 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 2476 | 1.924 | 0.4431 | Yes |
| 23 | BTG3 | BTG3 Entrez, Source | BTG family, member 3 | 3115 | 1.551 | 0.4112 | Yes |
| 24 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 3223 | 1.499 | 0.4173 | Yes |
| 25 | ZC3H12C | ZC3H12C Entrez, Source | zinc finger CCCH-type containing 12C | 3372 | 1.416 | 0.4196 | Yes |
| 26 | LRP8 | LRP8 Entrez, Source | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 3430 | 1.391 | 0.4283 | Yes |
| 27 | EYA3 | EYA3 Entrez, Source | eyes absent homolog 3 (Drosophila) | 3557 | 1.335 | 0.4315 | Yes |
| 28 | DDIT4L | DDIT4L Entrez, Source | DNA-damage-inducible transcript 4-like | 3651 | 1.296 | 0.4367 | Yes |
| 29 | SERPINB2 | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 3806 | 1.226 | 0.4368 | Yes |
| 30 | DKK1 | DKK1 Entrez, Source | dickkopf homolog 1 (Xenopus laevis) | 3862 | 1.198 | 0.4439 | Yes |
| 31 | CCK | CCK Entrez, Source | cholecystokinin | 3921 | 1.174 | 0.4505 | Yes |
| 32 | POLH | POLH Entrez, Source | polymerase (DNA directed), eta | 4653 | 0.901 | 0.4059 | No |
| 33 | LOC284454 | LOC284454 Entrez, Source | - | 5456 | 0.639 | 0.3537 | No |
| 34 | IL11 | IL11 Entrez, Source | interleukin 11 | 5870 | 0.516 | 0.3286 | No |
| 35 | TNFRSF10C | TNFRSF10C Entrez, Source | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 5881 | 0.512 | 0.3326 | No |
| 36 | GPR68 | GPR68 Entrez, Source | G protein-coupled receptor 68 | 6345 | 0.394 | 0.3027 | No |
| 37 | TNFAIP3 | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 6627 | 0.323 | 0.2854 | No |
| 38 | NFKBIZ | NFKBIZ Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 6686 | 0.311 | 0.2840 | No |
| 39 | DUSP2 | DUSP2 Entrez, Source | dual specificity phosphatase 2 | 7241 | 0.165 | 0.2455 | No |
| 40 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 7269 | 0.158 | 0.2450 | No |
| 41 | RRM2B | RRM2B Entrez, Source | ribonucleotide reductase M2 B (TP53 inducible) | 7533 | 0.088 | 0.2267 | No |
| 42 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 8144 | -0.082 | 0.1833 | No |
| 43 | SESN1 | SESN1 Entrez, Source | sestrin 1 | 8184 | -0.094 | 0.1814 | No |
| 44 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 8308 | -0.124 | 0.1736 | No |
| 45 | BMP2 | BMP2 Entrez, Source | bone morphogenetic protein 2 | 8586 | -0.208 | 0.1555 | No |
| 46 | FAM20A | FAM20A Entrez, Source | family with sequence similarity 20, member A | 8765 | -0.269 | 0.1451 | No |
| 47 | POU5F1 | POU5F1 Entrez, Source | POU domain, class 5, transcription factor 1 | 8938 | -0.327 | 0.1357 | No |
| 48 | GDNF | GDNF Entrez, Source | glial cell derived neurotrophic factor | 9462 | -0.507 | 0.1025 | No |
| 49 | MYBL1 | MYBL1 Entrez, Source | v-myb myeloblastosis viral oncogene homolog (avian)-like 1 | 9669 | -0.580 | 0.0929 | No |
| 50 | MT1X | MT1X Entrez, Source | metallothionein 1X | 10035 | -0.745 | 0.0734 | No |
| 51 | SLC30A1 | SLC30A1 Entrez, Source | solute carrier family 30 (zinc transporter), member 1 | 10115 | -0.784 | 0.0749 | No |
| 52 | MT1E | MT1E Entrez, Source | metallothionein 1E (functional) | 10167 | -0.810 | 0.0786 | No |
| 53 | THSD1 | THSD1 Entrez, Source | thrombospondin, type I, domain containing 1 | 10626 | -1.029 | 0.0550 | No |
| 54 | MT1G | MT1G Entrez, Source | metallothionein 1G | 10690 | -1.062 | 0.0602 | No |
| 55 | MT1B | MT1B Entrez, Source | metallothionein 1B (functional) | 10738 | -1.090 | 0.0668 | No |
| 56 | MT1L | MT1L Entrez, Source | metallothionein 1L (pseudogene) | 11169 | -1.310 | 0.0478 | No |
| 57 | KYNU | KYNU Entrez, Source | kynureninase (L-kynurenine hydrolase) | 11183 | -1.317 | 0.0590 | No |
| 58 | MT2A | MT2A Entrez, Source | metallothionein 2A | 11386 | -1.430 | 0.0575 | No |
| 59 | E2F7 | E2F7 Entrez, Source | E2F transcription factor 7 | 11803 | -1.697 | 0.0430 | No |
| 60 | SLC16A3 | SLC16A3 Entrez, Source | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) | 11843 | -1.729 | 0.0561 | No |
| 61 | MT1A | MT1A Entrez, Source | metallothionein 1A (functional) | 12050 | -1.874 | 0.0585 | No |
| 62 | SLC16A6 | SLC16A6 Entrez, Source | solute carrier family 16, member 6 (monocarboxylic acid transporter 7) | 12052 | -1.875 | 0.0757 | No |
| 63 | FRMD4A | FRMD4A Entrez, Source | FERM domain containing 4A | 13066 | -2.891 | 0.0290 | No |
| 64 | CYP26B1 | CYP26B1 Entrez, Source | cytochrome P450, family 26, subfamily B, polypeptide 1 | 13360 | -3.264 | 0.0378 | No |
