Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #24hr_versus_0hr.class.cls #24hr_versus_0hr_repos |
| Phenotype | class.cls#24hr_versus_0hr_repos |
| Upregulated in class | 24hr |
| GeneSet | LAU_APOPTOSIS_CDKN2A_UP |
| Enrichment Score (ES) | 0.39040938 |
| Normalized Enrichment Score (NES) | 1.8402843 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.88676554 |
| FWER p-Value | 0.412 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 44 | 4.481 | 0.0454 | Yes |
| 2 | CLU | CLU Entrez, Source | clusterin | 299 | 3.889 | 0.0692 | Yes |
| 3 | PAWR | PAWR Entrez, Source | PRKC, apoptosis, WT1, regulator | 502 | 3.605 | 0.0937 | Yes |
| 4 | TNFRSF10B | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 701 | 3.400 | 0.1163 | Yes |
| 5 | TRAF3 | TRAF3 Entrez, Source | TNF receptor-associated factor 3 | 1052 | 3.014 | 0.1237 | Yes |
| 6 | TP53BP2 | TP53BP2 Entrez, Source | tumor protein p53 binding protein, 2 | 1053 | 3.013 | 0.1563 | Yes |
| 7 | TNFRSF12A | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 1129 | 2.947 | 0.1829 | Yes |
| 8 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1200 | 2.898 | 0.2092 | Yes |
| 9 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 1578 | 2.569 | 0.2098 | Yes |
| 10 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 1581 | 2.568 | 0.2375 | Yes |
| 11 | BAG5 | BAG5 Entrez, Source | BCL2-associated athanogene 5 | 1630 | 2.532 | 0.2615 | Yes |
| 12 | CIZ1 | CIZ1 Entrez, Source | CDKN1A interacting zinc finger protein 1 | 1654 | 2.507 | 0.2870 | Yes |
| 13 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 1859 | 2.362 | 0.2979 | Yes |
| 14 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1972 | 2.284 | 0.3146 | Yes |
| 15 | BNIP2 | BNIP2 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 2 | 2281 | 2.049 | 0.3145 | Yes |
| 16 | TNFSF9 | TNFSF9 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 9 | 2524 | 1.891 | 0.3175 | Yes |
| 17 | ACIN1 | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 2528 | 1.886 | 0.3378 | Yes |
| 18 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 2594 | 1.851 | 0.3532 | Yes |
| 19 | BCL10 | BCL10 Entrez, Source | B-cell CLL/lymphoma 10 | 2812 | 1.724 | 0.3562 | Yes |
| 20 | PDCD11 | PDCD11 Entrez, Source | programmed cell death 11 | 3091 | 1.561 | 0.3530 | Yes |
| 21 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 3205 | 1.507 | 0.3612 | Yes |
| 22 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 3240 | 1.492 | 0.3749 | Yes |
| 23 | PDCD6IP | PDCD6IP Entrez, Source | programmed cell death 6 interacting protein | 3249 | 1.484 | 0.3904 | Yes |
| 24 | DIABLO | DIABLO Entrez, Source | diablo homolog (Drosophila) | 3809 | 1.225 | 0.3633 | No |
| 25 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 5459 | 0.637 | 0.2510 | No |
| 26 | DAP | DAP Entrez, Source | death-associated protein | 5639 | 0.588 | 0.2444 | No |
| 27 | TNFAIP3 | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 6627 | 0.323 | 0.1766 | No |
| 28 | BCL2L11 | BCL2L11 Entrez, Source | BCL2-like 11 (apoptosis facilitator) | 7317 | 0.143 | 0.1283 | No |
| 29 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 7644 | 0.056 | 0.1054 | No |
| 30 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 8550 | -0.197 | 0.0421 | No |
| 31 | PAK4 | PAK4 Entrez, Source | p21(CDKN1A)-activated kinase 4 | 8705 | -0.247 | 0.0336 | No |
| 32 | CARD10 | CARD10 Entrez, Source | caspase recruitment domain family, member 10 | 8940 | -0.327 | 0.0202 | No |
| 33 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9198 | -0.410 | 0.0061 | No |
| 34 | NDUFA13 | NDUFA13 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | 9547 | -0.533 | -0.0133 | No |
| 35 | TRAF4 | TRAF4 Entrez, Source | TNF receptor-associated factor 4 | 9642 | -0.573 | -0.0139 | No |
| 36 | BCLAF1 | BCLAF1 Entrez, Source | BCL2-associated transcription factor 1 | 9675 | -0.584 | -0.0098 | No |
| 37 | CASP2 | CASP2 Entrez, Source | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | 10523 | -0.983 | -0.0604 | No |
| 38 | SIAH1 | SIAH1 Entrez, Source | seven in absentia homolog 1 (Drosophila) | 10619 | -1.027 | -0.0561 | No |
| 39 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 10734 | -1.089 | -0.0526 | No |
| 40 | PDCD6 | PDCD6 Entrez, Source | programmed cell death 6 | 11471 | -1.489 | -0.0896 | No |
| 41 | MYBL2 | MYBL2 Entrez, Source | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 | 11472 | -1.492 | -0.0735 | No |
| 42 | RAD21 | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 11644 | -1.601 | -0.0685 | No |
| 43 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 11897 | -1.771 | -0.0675 | No |
| 44 | GMNN | GMNN Entrez, Source | geminin, DNA replication inhibitor | 12238 | -2.026 | -0.0701 | No |
| 45 | PDCD4 | PDCD4 Entrez, Source | programmed cell death 4 (neoplastic transformation inhibitor) | 12322 | -2.094 | -0.0534 | No |
| 46 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 12369 | -2.139 | -0.0335 | No |
| 47 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12479 | -2.240 | -0.0171 | No |
| 48 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 12539 | -2.300 | 0.0036 | No |
| 49 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 12652 | -2.412 | 0.0216 | No |
| 50 | MYCBP | MYCBP Entrez, Source | c-myc binding protein | 12893 | -2.666 | 0.0332 | No |
| 51 | TRAF5 | TRAF5 Entrez, Source | TNF receptor-associated factor 5 | 13528 | -3.531 | 0.0257 | No |
