Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #24hr_versus_0hr.class.cls #24hr_versus_0hr_repos |
| Phenotype | class.cls#24hr_versus_0hr_repos |
| Upregulated in class | 0hr |
| GeneSet | REACTOME_CHROMOSOME_MAINTENANCE |
| Enrichment Score (ES) | -0.5766587 |
| Normalized Enrichment Score (NES) | -1.3763038 |
| Nominal p-value | 0.11553785 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | STAG3 | STAG3 Entrez, Source | stromal antigen 3 | 1434 | 2.702 | -0.0811 | No |
| 2 | LMNA | LMNA Entrez, Source | lamin A/C | 1963 | 2.290 | -0.0999 | No |
| 3 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 2337 | 2.020 | -0.1099 | No |
| 4 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 3182 | 1.521 | -0.1582 | No |
| 5 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 3451 | 1.383 | -0.1659 | No |
| 6 | DKC1 | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 3939 | 1.164 | -0.1913 | No |
| 7 | LOC440577 | LOC440577 Entrez, Source | - | 4929 | 0.808 | -0.2561 | No |
| 8 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 5522 | 0.617 | -0.2938 | No |
| 9 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 5671 | 0.577 | -0.2997 | No |
| 10 | SMARCA5 | SMARCA5 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 5815 | 0.534 | -0.3055 | No |
| 11 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 6242 | 0.422 | -0.3328 | No |
| 12 | FKBP6 | FKBP6 Entrez, Source | FK506 binding protein 6, 36kDa | 6456 | 0.367 | -0.3451 | No |
| 13 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 6594 | 0.333 | -0.3523 | No |
| 14 | ITGB3BP | ITGB3BP Entrez, Source | integrin beta 3 binding protein (beta3-endonexin) | 6933 | 0.244 | -0.3747 | No |
| 15 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 7170 | 0.179 | -0.3903 | No |
| 16 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 7368 | 0.127 | -0.4035 | No |
| 17 | SYCP3 | SYCP3 Entrez, Source | synaptonemal complex protein 3 | 7437 | 0.113 | -0.4074 | No |
| 18 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 7514 | 0.092 | -0.4122 | No |
| 19 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 7742 | 0.029 | -0.4284 | No |
| 20 | HIST3H3 | HIST3H3 Entrez, Source | histone cluster 3, H3 | 8178 | -0.091 | -0.4591 | No |
| 21 | STAG1 | STAG1 Entrez, Source | stromal antigen 1 | 8642 | -0.225 | -0.4908 | No |
| 22 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 9121 | -0.388 | -0.5221 | No |
| 23 | NPM1 | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 9295 | -0.441 | -0.5309 | No |
| 24 | POLA2 | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 9404 | -0.489 | -0.5346 | No |
| 25 | POLE | POLE Entrez, Source | polymerase (DNA directed), epsilon | 9437 | -0.498 | -0.5327 | No |
| 26 | HSPA2 | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 9448 | -0.501 | -0.5292 | No |
| 27 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 9696 | -0.593 | -0.5421 | No |
| 28 | HIST1H4A | HIST1H4A Entrez, Source | histone cluster 1, H4a | 10174 | -0.813 | -0.5698 | Yes |
| 29 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 10238 | -0.846 | -0.5672 | Yes |
| 30 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 10321 | -0.883 | -0.5656 | Yes |
| 31 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 10353 | -0.899 | -0.5603 | Yes |
| 32 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 10374 | -0.913 | -0.5540 | Yes |
| 33 | STAG2 | STAG2 Entrez, Source | stromal antigen 2 | 10410 | -0.925 | -0.5487 | Yes |
| 34 | POLD4 | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 10606 | -1.021 | -0.5542 | Yes |
| 35 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 10668 | -1.051 | -0.5497 | Yes |
| 36 | HIST1H2BM | HIST1H2BM Entrez, Source | histone cluster 1, H2bm | 10707 | -1.073 | -0.5434 | Yes |
| 37 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 10709 | -1.075 | -0.5344 | Yes |
| 38 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 10864 | -1.158 | -0.5357 | Yes |
| 39 | HIST1H4B | HIST1H4B Entrez, Source | histone cluster 1, H4b | 10960 | -1.202 | -0.5324 | Yes |
| 40 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 11042 | -1.246 | -0.5277 | Yes |
| 41 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 11062 | -1.254 | -0.5185 | Yes |
| 42 | CENPA | CENPA Entrez, Source | centromere protein A | 11088 | -1.267 | -0.5096 | Yes |
| 43 | HIST1H4L | HIST1H4L Entrez, Source | histone cluster 1, H4l | 11179 | -1.315 | -0.5050 | Yes |
| 44 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 11248 | -1.350 | -0.4985 | Yes |
| 45 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 11273 | -1.367 | -0.4887 | Yes |
| 46 | HIST1H4C | HIST1H4C Entrez, Source | histone cluster 1, H4c | 11291 | -1.376 | -0.4782 | Yes |
| 47 | CASC5 | CASC5 Entrez, Source | cancer susceptibility candidate 5 | 11292 | -1.379 | -0.4666 | Yes |
| 48 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 11334 | -1.398 | -0.4577 | Yes |
| 49 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 11355 | -1.409 | -0.4472 | Yes |
| 50 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 11378 | -1.424 | -0.4368 | Yes |
| 51 | OIP5 | OIP5 Entrez, Source | Opa interacting protein 5 | 11448 | -1.474 | -0.4293 | Yes |
| 52 | HIST1H2AD | HIST1H2AD Entrez, Source | histone cluster 1, H2ad | 11455 | -1.479 | -0.4172 | Yes |
| 53 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 11459 | -1.481 | -0.4049 | Yes |
| 54 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 11514 | -1.513 | -0.3960 | Yes |
| 55 | HIST1H4D | HIST1H4D Entrez, Source | histone cluster 1, H4d | 11527 | -1.523 | -0.3840 | Yes |
| 56 | MLF1IP | MLF1IP Entrez, Source | MLF1 interacting protein | 11615 | -1.580 | -0.3769 | Yes |
| 57 | RAD21 | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 11644 | -1.601 | -0.3654 | Yes |
| 58 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 11658 | -1.610 | -0.3527 | Yes |
| 59 | HIST1H4F | HIST1H4F Entrez, Source | histone cluster 1, H4f | 11685 | -1.625 | -0.3408 | Yes |
| 60 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 11688 | -1.626 | -0.3272 | Yes |
| 61 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 11774 | -1.680 | -0.3192 | Yes |
| 62 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 11845 | -1.732 | -0.3096 | Yes |
| 63 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 11910 | -1.781 | -0.2991 | Yes |
| 64 | HIST1H2AJ | HIST1H2AJ Entrez, Source | histone cluster 1, H2aj | 11932 | -1.794 | -0.2855 | Yes |
| 65 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 12081 | -1.900 | -0.2801 | Yes |
| 66 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 12088 | -1.904 | -0.2644 | Yes |
| 67 | LMNB1 | LMNB1 Entrez, Source | lamin B1 | 12224 | -2.012 | -0.2572 | Yes |
| 68 | FEN1 | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 12296 | -2.073 | -0.2448 | Yes |
| 69 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 12343 | -2.116 | -0.2302 | Yes |
| 70 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 12369 | -2.139 | -0.2139 | Yes |
| 71 | HIST1H2AB | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 12399 | -2.171 | -0.1976 | Yes |
| 72 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 12432 | -2.197 | -0.1814 | Yes |
| 73 | RFC5 | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 12486 | -2.247 | -0.1662 | Yes |
| 74 | RBBP7 | RBBP7 Entrez, Source | retinoblastoma binding protein 7 | 12526 | -2.286 | -0.1497 | Yes |
| 75 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 12539 | -2.300 | -0.1311 | Yes |
| 76 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 12550 | -2.313 | -0.1122 | Yes |
| 77 | CENPH | CENPH Entrez, Source | centromere protein H | 12681 | -2.445 | -0.1009 | Yes |
| 78 | HIST1H4K | HIST1H4K Entrez, Source | histone cluster 1, H4k | 12765 | -2.538 | -0.0855 | Yes |
| 79 | HIST1H4J | HIST1H4J Entrez, Source | histone cluster 1, H4j | 12772 | -2.541 | -0.0644 | Yes |
| 80 | POLE2 | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 12776 | -2.544 | -0.0431 | Yes |
| 81 | SYNE2 | SYNE2 Entrez, Source | spectrin repeat containing, nuclear envelope 2 | 12803 | -2.574 | -0.0232 | Yes |
| 82 | RFC4 | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 13033 | -2.836 | -0.0157 | Yes |
| 83 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 13041 | -2.851 | 0.0079 | Yes |
| 84 | RBBP4 | RBBP4 Entrez, Source | retinoblastoma binding protein 4 | 13192 | -3.039 | 0.0227 | Yes |
| 85 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 13326 | -3.223 | 0.0404 | Yes |
