Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 0hr |
| GeneSet | COLDREN_GEFITINIB_RESISTANCE_DN |
| Enrichment Score (ES) | -0.5180705 |
| Normalized Enrichment Score (NES) | -1.5445925 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAM84B | FAM84B Entrez, Source | family with sequence similarity 84, member B | 941 | 2.030 | -0.0520 | No |
| 2 | PRRG4 | PRRG4 Entrez, Source | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) | 1430 | 1.582 | -0.0747 | No |
| 3 | SYTL1 | SYTL1 Entrez, Source | synaptotagmin-like 1 | 1583 | 1.461 | -0.0739 | No |
| 4 | MARVELD3 | MARVELD3 Entrez, Source | MARVEL domain containing 3 | 1745 | 1.355 | -0.0746 | No |
| 5 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 1850 | 1.307 | -0.0716 | No |
| 6 | RIPK4 | RIPK4 Entrez, Source | receptor-interacting serine-threonine kinase 4 | 2707 | 0.911 | -0.1265 | No |
| 7 | GUCY1B3 | GUCY1B3 Entrez, Source | guanylate cyclase 1, soluble, beta 3 | 2713 | 0.909 | -0.1194 | No |
| 8 | BSPRY | BSPRY Entrez, Source | B-box and SPRY domain containing | 2888 | 0.853 | -0.1252 | No |
| 9 | TMEM40 | TMEM40 Entrez, Source | transmembrane protein 40 | 3019 | 0.817 | -0.1280 | No |
| 10 | ZDHHC21 | ZDHHC21 Entrez, Source | zinc finger, DHHC-type containing 21 | 3024 | 0.816 | -0.1217 | No |
| 11 | KLC3 | KLC3 Entrez, Source | kinesin light chain 3 | 3054 | 0.808 | -0.1172 | No |
| 12 | KRT15 | KRT15 Entrez, Source | keratin 15 | 3194 | 0.770 | -0.1211 | No |
| 13 | KIAA1244 | KIAA1244 Entrez, Source | KIAA1244 | 3441 | 0.704 | -0.1333 | No |
| 14 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 3603 | 0.664 | -0.1396 | No |
| 15 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 4336 | 0.499 | -0.1888 | No |
| 16 | LGALS9 | LGALS9 Entrez, Source | lectin, galactoside-binding, soluble, 9 (galectin 9) | 4353 | 0.495 | -0.1860 | No |
| 17 | IRF6 | IRF6 Entrez, Source | interferon regulatory factor 6 | 4433 | 0.477 | -0.1879 | No |
| 18 | UNC13D | UNC13D Entrez, Source | unc-13 homolog D (C. elegans) | 4672 | 0.427 | -0.2017 | No |
| 19 | SESTD1 | SESTD1 Entrez, Source | SEC14 and spectrin domains 1 | 4885 | 0.386 | -0.2140 | No |
| 20 | FGD4 | FGD4 Entrez, Source | FYVE, RhoGEF and PH domain containing 4 | 4986 | 0.367 | -0.2183 | No |
| 21 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 5123 | 0.344 | -0.2254 | No |
| 22 | SH3BGRL2 | SH3BGRL2 Entrez, Source | SH3 domain binding glutamic acid-rich protein like 2 | 5210 | 0.327 | -0.2290 | No |
| 23 | SMPDL3B | SMPDL3B Entrez, Source | sphingomyelin phosphodiesterase, acid-like 3B | 5391 | 0.295 | -0.2397 | No |
| 24 | SH3YL1 | SH3YL1 Entrez, Source | SH3 domain containing, Ysc84-like 1 (S. cerevisiae) | 5702 | 0.242 | -0.2603 | No |
| 25 | ENPP4 | ENPP4 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function) | 5787 | 0.228 | -0.2646 | No |
| 26 | B3GNT3 | B3GNT3 Entrez, Source | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 5795 | 0.226 | -0.2633 | No |
| 27 | SRCAP | SRCAP Entrez, Source | - | 5833 | 0.221 | -0.2642 | No |
| 28 | MYH14 | MYH14 Entrez, Source | myosin, heavy chain 14 | 5901 | 0.208 | -0.2673 | No |
| 29 | S100A14 | S100A14 Entrez, Source | S100 calcium binding protein A14 | 5940 | 0.205 | -0.2684 | No |
| 30 | PEG10 | PEG10 Entrez, Source | paternally expressed 10 | 5970 | 0.201 | -0.2689 | No |
| 31 | GLI4 | GLI4 Entrez, Source | GLI-Kruppel family member GLI4 | 6011 | 0.195 | -0.2703 | No |
| 32 | ALDH1A3 | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 6063 | 0.188 | -0.2724 | No |
| 33 | KLK6 | KLK6 Entrez, Source | kallikrein 6 (neurosin, zyme) | 6215 | 0.163 | -0.2821 | No |
| 34 | ZNF600 | ZNF600 Entrez, Source | zinc finger protein 600 | 6312 | 0.147 | -0.2879 | No |
| 35 | SVIL | SVIL Entrez, Source | supervillin | 6456 | 0.125 | -0.2973 | No |
| 36 | REPS2 | REPS2 Entrez, Source | RALBP1 associated Eps domain containing 2 | 6527 | 0.115 | -0.3014 | No |
| 37 | AP1M2 | AP1M2 Entrez, Source | adaptor-related protein complex 1, mu 2 subunit | 6545 | 0.112 | -0.3018 | No |
| 38 | MAPK13 | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 6551 | 0.111 | -0.3012 | No |
| 39 | STK39 | STK39 Entrez, Source | serine threonine kinase 39 (STE20/SPS1 homolog, yeast) | 6569 | 0.106 | -0.3016 | No |
| 40 | KIAA0040 | KIAA0040 Entrez, Source | KIAA0040 | 6727 | 0.082 | -0.3124 | No |
| 41 | ZNF91 | ZNF91 Entrez, Source | zinc finger protein 91 | 6768 | 0.076 | -0.3147 | No |
| 42 | TMEM45B | TMEM45B Entrez, Source | transmembrane protein 45B | 6793 | 0.071 | -0.3159 | No |
| 43 | FGFBP1 | FGFBP1 Entrez, Source | fibroblast growth factor binding protein 1 | 6916 | 0.054 | -0.3243 | No |
| 44 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 6970 | 0.043 | -0.3278 | No |
| 45 | EPS8L2 | EPS8L2 Entrez, Source | EPS8-like 2 | 7122 | 0.021 | -0.3386 | No |
| 46 | TMEM30B | TMEM30B Entrez, Source | transmembrane protein 30B | 7341 | -0.011 | -0.3544 | No |
| 47 | RHOD | RHOD Entrez, Source | ras homolog gene family, member D | 7432 | -0.025 | -0.3608 | No |
| 48 | TTC22 | TTC22 Entrez, Source | tetratricopeptide repeat domain 22 | 7560 | -0.045 | -0.3696 | No |
| 49 | LRG1 | LRG1 Entrez, Source | leucine-rich alpha-2-glycoprotein 1 | 7577 | -0.048 | -0.3704 | No |
| 50 | MYO1D | MYO1D Entrez, Source | myosin ID | 7588 | -0.049 | -0.3707 | No |
| 51 | MPP7 | MPP7 Entrez, Source | membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) | 7633 | -0.057 | -0.3735 | No |
| 52 | GRHL3 | GRHL3 Entrez, Source | grainyhead-like 3 (Drosophila) | 7637 | -0.058 | -0.3732 | No |
| 53 | CNKSR1 | CNKSR1 Entrez, Source | connector enhancer of kinase suppressor of Ras 1 | 7665 | -0.062 | -0.3747 | No |
| 54 | ZNF468 | ZNF468 Entrez, Source | zinc finger protein 468 | 7898 | -0.101 | -0.3908 | No |
| 55 | ZNF43 | ZNF43 Entrez, Source | zinc finger protein 43 | 8072 | -0.127 | -0.4023 | No |
| 56 | AIM1L | AIM1L Entrez, Source | absent in melanoma 1-like | 8588 | -0.212 | -0.4381 | No |
| 57 | TMPRSS4 | TMPRSS4 Entrez, Source | transmembrane protease, serine 4 | 8603 | -0.213 | -0.4374 | No |
| 58 | SLC35A3 | SLC35A3 Entrez, Source | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 8650 | -0.220 | -0.4389 | No |
| 59 | KALRN | KALRN Entrez, Source | kalirin, RhoGEF kinase | 8651 | -0.220 | -0.4372 | No |
| 60 | ZNF506 | ZNF506 Entrez, Source | zinc finger protein 506 | 8704 | -0.229 | -0.4391 | No |
| 61 | STARD10 | STARD10 Entrez, Source | START domain containing 10 | 8845 | -0.255 | -0.4472 | No |
| 62 | PRRG2 | PRRG2 Entrez, Source | proline rich Gla (G-carboxyglutamic acid) 2 | 8851 | -0.257 | -0.4455 | No |
| 63 | WFDC3 | WFDC3 Entrez, Source | WAP four-disulfide core domain 3 | 8950 | -0.271 | -0.4504 | No |
| 64 | MLF1IP | MLF1IP Entrez, Source | MLF1 interacting protein | 9046 | -0.287 | -0.4550 | No |
| 65 | TSPAN1 | TSPAN1 Entrez, Source | tetraspanin 1 | 9152 | -0.304 | -0.4602 | No |
| 66 | STAP2 | STAP2 Entrez, Source | - | 9275 | -0.324 | -0.4664 | No |
| 67 | LAD1 | LAD1 Entrez, Source | ladinin 1 | 9373 | -0.340 | -0.4707 | No |
| 68 | GRHL1 | GRHL1 Entrez, Source | grainyhead-like 1 (Drosophila) | 9375 | -0.341 | -0.4680 | No |
| 69 | LMO7 | LMO7 Entrez, Source | LIM domain 7 | 9466 | -0.356 | -0.4717 | No |
| 70 | PLEKHF2 | PLEKHF2 Entrez, Source | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 9698 | -0.392 | -0.4853 | No |
| 71 | CAB39 | CAB39 Entrez, Source | calcium binding protein 39 | 9768 | -0.406 | -0.4870 | No |
| 72 | HMGCL | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 9785 | -0.409 | -0.4849 | No |
| 73 | GNAS | GNAS Entrez, Source | GNAS complex locus | 9809 | -0.415 | -0.4832 | No |
| 74 | PLEKHA7 | PLEKHA7 Entrez, Source | pleckstrin homology domain containing, family A member 7 | 9846 | -0.421 | -0.4824 | No |
| 75 | GCA | GCA Entrez, Source | grancalcin, EF-hand calcium binding protein | 9849 | -0.422 | -0.4791 | No |
| 76 | WDFY1 | WDFY1 Entrez, Source | WD repeat and FYVE domain containing 1 | 9960 | -0.439 | -0.4835 | No |
| 77 | GAB1 | GAB1 Entrez, Source | GRB2-associated binding protein 1 | 10027 | -0.451 | -0.4847 | No |
| 78 | PTK6 | PTK6 Entrez, Source | PTK6 protein tyrosine kinase 6 | 10035 | -0.453 | -0.4815 | No |
| 79 | ATPIF1 | ATPIF1 Entrez, Source | ATPase inhibitory factor 1 | 10244 | -0.489 | -0.4927 | No |
| 80 | ELF3 | ELF3 Entrez, Source | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 10278 | -0.495 | -0.4911 | No |
| 81 | MYO6 | MYO6 Entrez, Source | myosin VI | 10283 | -0.495 | -0.4873 | No |
| 82 | EPPK1 | EPPK1 Entrez, Source | epiplakin 1 | 10458 | -0.530 | -0.4957 | No |
| 83 | ENPP5 | ENPP5 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function) | 10697 | -0.574 | -0.5084 | No |
| 84 | MAL2 | MAL2 Entrez, Source | mal, T-cell differentiation protein 2 | 10757 | -0.588 | -0.5079 | No |
| 85 | EPN3 | EPN3 Entrez, Source | epsin 3 | 10898 | -0.618 | -0.5131 | Yes |
| 86 | GUK1 | GUK1 Entrez, Source | guanylate kinase 1 | 10943 | -0.629 | -0.5111 | Yes |
| 87 | FAM3C | FAM3C Entrez, Source | family with sequence similarity 3, member C | 10967 | -0.635 | -0.5077 | Yes |
| 88 | PDE5A | PDE5A Entrez, Source | phosphodiesterase 5A, cGMP-specific | 11066 | -0.659 | -0.5094 | Yes |
| 89 | EXPH5 | EXPH5 Entrez, Source | exophilin 5 | 11069 | -0.659 | -0.5042 | Yes |
| 90 | CAPS | CAPS Entrez, Source | calcyphosine | 11185 | -0.691 | -0.5070 | Yes |
| 91 | OCLN | OCLN Entrez, Source | occludin | 11307 | -0.728 | -0.5099 | Yes |
| 92 | VAV3 | VAV3 Entrez, Source | vav 3 oncogene | 11361 | -0.742 | -0.5077 | Yes |
| 93 | FOXA1 | FOXA1 Entrez, Source | forkhead box A1 | 11365 | -0.743 | -0.5019 | Yes |
| 94 | BIK | BIK Entrez, Source | BCL2-interacting killer (apoptosis-inducing) | 11418 | -0.758 | -0.4995 | Yes |
| 95 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 11513 | -0.786 | -0.5000 | Yes |
| 96 | COMT | COMT Entrez, Source | catechol-O-methyltransferase | 11535 | -0.791 | -0.4951 | Yes |
| 97 | KIAA1522 | KIAA1522 Entrez, Source | KIAA1522 | 11685 | -0.833 | -0.4992 | Yes |
| 98 | S100A16 | S100A16 Entrez, Source | S100 calcium binding protein A16 | 11724 | -0.844 | -0.4951 | Yes |
| 99 | ZNF681 | ZNF681 Entrez, Source | zinc finger protein 681 | 11760 | -0.855 | -0.4907 | Yes |
| 100 | TJP2 | TJP2 Entrez, Source | tight junction protein 2 (zona occludens 2) | 11786 | -0.864 | -0.4855 | Yes |
| 101 | RAB25 | RAB25 Entrez, Source | RAB25, member RAS oncogene family | 11832 | -0.874 | -0.4816 | Yes |
| 102 | CDS1 | CDS1 Entrez, Source | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 11847 | -0.881 | -0.4755 | Yes |
| 103 | PRSS22 | PRSS22 Entrez, Source | protease, serine, 22 | 11868 | -0.890 | -0.4697 | Yes |
| 104 | CYP2J2 | CYP2J2 Entrez, Source | cytochrome P450, family 2, subfamily J, polypeptide 2 | 11917 | -0.905 | -0.4659 | Yes |
| 105 | PRSS8 | PRSS8 Entrez, Source | protease, serine, 8 (prostasin) | 11950 | -0.916 | -0.4608 | Yes |
| 106 | COBLL1 | COBLL1 Entrez, Source | COBL-like 1 | 11968 | -0.921 | -0.4545 | Yes |
| 107 | ST14 | ST14 Entrez, Source | suppression of tumorigenicity 14 (colon carcinoma) | 11972 | -0.924 | -0.4473 | Yes |
| 108 | GALNT3 | GALNT3 Entrez, Source | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) | 11983 | -0.927 | -0.4404 | Yes |
| 109 | FRMD4B | FRMD4B Entrez, Source | FERM domain containing 4B | 12026 | -0.942 | -0.4359 | Yes |
| 110 | DDR1 | DDR1 Entrez, Source | discoidin domain receptor family, member 1 | 12095 | -0.965 | -0.4330 | Yes |
| 111 | AIG1 | AIG1 Entrez, Source | androgen-induced 1 | 12099 | -0.967 | -0.4253 | Yes |
| 112 | RNF141 | RNF141 Entrez, Source | ring finger protein 141 | 12123 | -0.974 | -0.4191 | Yes |
| 113 | SLC1A1 | SLC1A1 Entrez, Source | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 12203 | -1.008 | -0.4166 | Yes |
| 114 | CST6 | CST6 Entrez, Source | cystatin E/M | 12232 | -1.018 | -0.4104 | Yes |
| 115 | TMC4 | TMC4 Entrez, Source | transmembrane channel-like 4 | 12240 | -1.021 | -0.4026 | Yes |
| 116 | EPHA1 | EPHA1 Entrez, Source | EPH receptor A1 | 12241 | -1.023 | -0.3943 | Yes |
| 117 | CDH1 | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 12333 | -1.061 | -0.3923 | Yes |
| 118 | ADK | ADK Entrez, Source | adenosine kinase | 12460 | -1.117 | -0.3924 | Yes |
| 119 | TJP3 | TJP3 Entrez, Source | tight junction protein 3 (zona occludens 3) | 12567 | -1.172 | -0.3906 | Yes |
| 120 | ANXA9 | ANXA9 Entrez, Source | annexin A9 | 12642 | -1.206 | -0.3862 | Yes |
| 121 | EPS8L1 | EPS8L1 Entrez, Source | EPS8-like 1 | 12661 | -1.215 | -0.3776 | Yes |
| 122 | TACSTD2 | TACSTD2 Entrez, Source | tumor-associated calcium signal transducer 2 | 12858 | -1.322 | -0.3812 | Yes |
| 123 | RAB11FIP4 | RAB11FIP4 Entrez, Source | RAB11 family interacting protein 4 (class II) | 12884 | -1.332 | -0.3722 | Yes |
| 124 | SPINT1 | SPINT1 Entrez, Source | serine peptidase inhibitor, Kunitz type 1 | 12894 | -1.337 | -0.3620 | Yes |
| 125 | MST1R | MST1R Entrez, Source | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | 12910 | -1.346 | -0.3521 | Yes |
| 126 | EMB | EMB Entrez, Source | embigin homolog (mouse) | 12924 | -1.361 | -0.3420 | Yes |
| 127 | GPR160 | GPR160 Entrez, Source | G protein-coupled receptor 160 | 12949 | -1.381 | -0.3325 | Yes |
| 128 | VAMP8 | VAMP8 Entrez, Source | vesicle-associated membrane protein 8 (endobrevin) | 12956 | -1.389 | -0.3217 | Yes |
| 129 | DST | DST Entrez, Source | dystonin | 13097 | -1.508 | -0.3196 | Yes |
| 130 | LOC440335 | LOC440335 Entrez, Source | - | 13156 | -1.566 | -0.3111 | Yes |
| 131 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 13181 | -1.589 | -0.3000 | Yes |
| 132 | ERBB3 | ERBB3 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 13367 | -1.818 | -0.2987 | Yes |
| 133 | RASEF | RASEF Entrez, Source | RAS and EF-hand domain containing | 13398 | -1.855 | -0.2858 | Yes |
| 134 | CGN | CGN Entrez, Source | cingulin | 13469 | -1.958 | -0.2750 | Yes |
| 135 | AIM1 | AIM1 Entrez, Source | absent in melanoma 1 | 13475 | -1.963 | -0.2594 | Yes |
| 136 | HS3ST1 | HS3ST1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 13535 | -2.079 | -0.2468 | Yes |
| 137 | KRT19 | KRT19 Entrez, Source | keratin 19 | 13538 | -2.082 | -0.2301 | Yes |
| 138 | LIPH | LIPH Entrez, Source | lipase, member H | 13568 | -2.148 | -0.2147 | Yes |
| 139 | ELMO3 | ELMO3 Entrez, Source | engulfment and cell motility 3 | 13653 | -2.356 | -0.2017 | Yes |
| 140 | SCAMP2 | SCAMP2 Entrez, Source | secretory carrier membrane protein 2 | 13657 | -2.363 | -0.1827 | Yes |
| 141 | PSD4 | PSD4 Entrez, Source | pleckstrin and Sec7 domain containing 4 | 13688 | -2.453 | -0.1650 | Yes |
| 142 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 13824 | -3.198 | -0.1488 | Yes |
| 143 | CLDN9 | CLDN9 Entrez, Source | claudin 9 | 13830 | -3.244 | -0.1228 | Yes |
| 144 | PPL | PPL Entrez, Source | periplakin | 13847 | -3.420 | -0.0962 | Yes |
| 145 | CCNG2 | CCNG2 Entrez, Source | cyclin G2 | 13866 | -3.873 | -0.0661 | Yes |
| 146 | GRHL2 | GRHL2 Entrez, Source | grainyhead-like 2 (Drosophila) | 13872 | -4.116 | -0.0330 | Yes |
| 147 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 13873 | -4.152 | 0.0007 | Yes |
