Datasetdata_collapsed_to_symbols.class.cls
#4hr_versus_0hr.class.cls
#4hr_versus_0hr_repos
Phenotypeclass.cls#4hr_versus_0hr_repos
Upregulated in class4hr
GeneSetHELLER_HDAC_TARGETS_DN
Enrichment Score (ES)0.4406993
Normalized Enrichment Score (NES)1.7646874
Nominal p-value0.0
FDR q-value0.535833
FWER p-Value0.557
Table: GSEA Results Summary



Fig 1: Enrichment plot: HELLER_HDAC_TARGETS_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1FASFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)84.5490.0215Yes
2KIAA0090KIAA0090
Entrez,  Source
KIAA0090414.0170.0386Yes
3EIF5EIF5
Entrez,  Source
eukaryotic translation initiation factor 5653.8340.0555Yes
4SEC24DSEC24D
Entrez,  Source
SEC24 related gene family, member D (S. cerevisiae)783.7690.0729Yes
5INPP5DINPP5D
Entrez,  Source
inositol polyphosphate-5-phosphatase, 145kDa803.7650.0911Yes
6CTHCTH
Entrez,  Source
cystathionase (cystathionine gamma-lyase)1913.2580.0989Yes
7KIAA0368KIAA0368
Entrez,  Source
KIAA03682563.0950.1092Yes
8TIMM44TIMM44
Entrez,  Source
translocase of inner mitochondrial membrane 44 homolog (yeast)3942.7830.1127Yes
9CEACAM1CEACAM1
Entrez,  Source
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)4432.6940.1223Yes
10HSPH1HSPH1
Entrez,  Source
heat shock 105kDa/110kDa protein 14462.6910.1352Yes
11SLC7A5SLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 54562.6720.1475Yes
12IL6RIL6R
Entrez,  Source
interleukin 6 receptor4702.6500.1594Yes
13SLC7A11SLC7A11
Entrez,  Source
solute carrier family 7, (cationic amino acid transporter, y+ system) member 114872.6160.1709Yes
14KLHL21KLHL21
Entrez,  Source
kelch-like 21 (Drosophila)4882.6130.1836Yes
15SLC1A4SLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 45362.5380.1924Yes
16INHBEINHBE
Entrez,  Source
inhibin, beta E5392.5320.2046Yes
17ERO1LBERO1LB
Entrez,  Source
ERO1-like beta (S. cerevisiae)5672.4920.2147Yes
18PPP1R15APPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A6732.3440.2184Yes
19PMAIP1PMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 17182.2690.2262Yes
20SLC3A2SLC3A2
Entrez,  Source
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 27232.2650.2369Yes
21ABCE1ABCE1
Entrez,  Source
ATP-binding cassette, sub-family E (OABP), member 17972.1770.2421Yes
22CEBPBCEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta7982.1740.2526Yes
23CEBPGCEBPG
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), gamma8102.1580.2623Yes
24HMOX1HMOX1
Entrez,  Source
heme oxygenase (decycling) 18252.1440.2717Yes
25DDIT3DDIT3
Entrez,  Source
DNA-damage-inducible transcript 39112.0590.2754Yes
26GADD45AGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha9602.0090.2817Yes
27DNAJB1DNAJB1
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 19622.0080.2914Yes
28HSPA6HSPA6
Entrez,  Source
heat shock 70kDa protein 6 (HSP70B')9652.0040.3009Yes
29PSAT1PSAT1
Entrez,  Source
phosphoserine aminotransferase 110181.9550.3066Yes
30HERPUD1HERPUD1
Entrez,  Source
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 110461.9260.3140Yes
31HSPA1AHSPA1A
Entrez,  Source
heat shock 70kDa protein 1A10711.9030.3215Yes
32ZBTB38ZBTB38
Entrez,  Source
zinc finger and BTB domain containing 3811571.8290.3241Yes
33ADCY7ADCY7
Entrez,  Source
adenylate cyclase 712151.7650.3285Yes
34LRP8LRP8
Entrez,  Source
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor12391.7510.3353Yes
35CNIH3CNIH3
Entrez,  Source
cornichon homolog 3 (Drosophila)13671.6360.3340Yes
36ATF3ATF3
Entrez,  Source
activating transcription factor 313991.6100.3395Yes
37MBPMBP
Entrez,  Source
myelin basic protein14231.5910.3455Yes
38HSPD1HSPD1
Entrez,  Source
heat shock 60kDa protein 1 (chaperonin)14531.5620.3510Yes
39AK1AK1
Entrez,  Source
adenylate kinase 116471.4140.3438Yes
40SERP1SERP1
Entrez,  Source
-16481.4130.3506Yes
41ATF4ATF4
Entrez,  Source
activating transcription factor 4 (tax-responsive enhancer element B67)16941.3830.3540Yes
42PUS1PUS1
Entrez,  Source
pseudouridylate synthase 117251.3630.3585Yes
43HSPE1HSPE1
Entrez,  Source
heat shock 10kDa protein 1 (chaperonin 10)17611.3470.3624Yes
44SMYD5SMYD5
Entrez,  Source
SMYD family member 517801.3400.3676Yes
45CUL1CUL1
Entrez,  Source
cullin 117831.3380.3740Yes
46RANRAN
Entrez,  Source
RAN, member RAS oncogene family17871.3360.3802Yes
47PKD1PKD1
Entrez,  Source
polycystic kidney disease 1 (autosomal dominant)19181.2660.3769Yes
48UBE2E1UBE2E1
Entrez,  Source
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)19931.2230.3774Yes
49RRS1RRS1
Entrez,  Source
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)20131.2120.3819Yes
50SERPINH1SERPINH1
Entrez,  Source
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)20211.2060.3872Yes
51PAK1IP1PAK1IP1
Entrez,  Source
PAK1 interacting protein 120411.1970.3916Yes
52PPRC1PPRC1
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator-related 120791.1750.3946Yes
53FKBP4FKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa20861.1730.3999Yes
54IL21RIL21R
Entrez,  Source
interleukin 21 receptor21231.1600.4029Yes
55PHF11PHF11
Entrez,  Source
PHD finger protein 1122181.1150.4014Yes
56TRIB3TRIB3
Entrez,  Source
tribbles homolog 3 (Drosophila)22921.0780.4013Yes
57OSBPL1AOSBPL1A
Entrez,  Source
oxysterol binding protein-like 1A23601.0480.4015Yes
58HSPA5HSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)23711.0430.4058Yes
59PSPHPSPH
Entrez,  Source
phosphoserine phosphatase23921.0340.4094Yes
60MAFFMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)24211.0210.4123Yes
61NFE2L1NFE2L1
Entrez,  Source
nuclear factor (erythroid-derived 2)-like 124401.0130.4159Yes
62TYMSTYMS
Entrez,  Source
thymidylate synthetase24411.0130.4208Yes
63PPFIBP1PPFIBP1
Entrez,  Source
PTPRF interacting protein, binding protein 1 (liprin beta 1)25190.9740.4199Yes
64HOMER3HOMER3
Entrez,  Source
homer homolog 3 (Drosophila)25460.9620.4227Yes
65BAG3BAG3
Entrez,  Source
BCL2-associated athanogene 325640.9570.4261Yes
66ISG20ISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa25700.9560.4303Yes
67SHMT2SHMT2
Entrez,  Source
serine hydroxymethyltransferase 2 (mitochondrial)26870.9160.4263Yes
68LARP1LARP1
Entrez,  Source
La ribonucleoprotein domain family, member 126930.9150.4304Yes
69SFPQSFPQ
Entrez,  Source
splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)28650.8610.4220Yes
70DFFBDFFB
Entrez,  Source
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)28770.8570.4254Yes
71CLK1CLK1
Entrez,  Source
CDC-like kinase 129080.8470.4273Yes
72LRRC41LRRC41
Entrez,  Source
leucine rich repeat containing 4129410.8370.4290Yes
73CBSCBS
Entrez,  Source
cystathionine-beta-synthase29460.8350.4328Yes
74CD44CD44
Entrez,  Source
CD44 molecule (Indian blood group)29530.8330.4364Yes
75PPIFPPIF
Entrez,  Source
peptidylprolyl isomerase F (cyclophilin F)29890.8240.4378Yes
76MYCNMYCN
Entrez,  Source
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)30560.8080.4369Yes
77FMNL1FMNL1
Entrez,  Source
formin-like 130590.8070.4407Yes
78CDK5R1CDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)31390.7870.4387No
79IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 133010.7400.4306No
80PLA2G4BPLA2G4B
Entrez,  Source
phospholipase A2, group IVB (cytosolic)34240.7090.4251No
81ELAC2ELAC2
Entrez,  Source
elaC homolog 2 (E. coli)35560.6760.4188No
82CALRCALR
Entrez,  Source
calreticulin35570.6760.4221No
83GBAGBA
Entrez,  Source
glucosidase, beta; acid (includes glucosylceramidase)35670.6730.4247No
84PFKPPFKP
Entrez,  Source
phosphofructokinase, platelet35770.6700.4273No
85SELPLGSELPLG
Entrez,  Source
selectin P ligand36620.6530.4243No
86FABP5FABP5
Entrez,  Source
fatty acid binding protein 5 (psoriasis-associated)38540.6060.4133No
87DNAJB4DNAJB4
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 439790.5730.4070No
88MYCL1MYCL1
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)40150.5660.4072No
89RORARORA
Entrez,  Source
RAR-related orphan receptor A41890.5310.3972No
90CFLARCFLAR
Entrez,  Source
CASP8 and FADD-like apoptosis regulator43580.4930.3873No
91IGKCIGKC
Entrez,  Source
immunoglobulin kappa constant44060.4830.3862No
92QPCTQPCT
Entrez,  Source
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)44660.4710.3842No
93OGTOGT
Entrez,  Source
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)46230.4380.3749No
94RPS19RPS19
Entrez,  Source
ribosomal protein S1946320.4360.3764No
95SLC33A1SLC33A1
Entrez,  Source
solute carrier family 33 (acetyl-CoA transporter), member 149520.3730.3549No
96NUP210NUP210
Entrez,  Source
nucleoporin 210kDa52560.3190.3343No
97MYCMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)53550.3000.3286No
98MFNGMFNG
Entrez,  Source
manic fringe homolog (Drosophila)54070.2930.3263No
99MRPL3MRPL3
Entrez,  Source
mitochondrial ribosomal protein L354930.2760.3215No
100TPP1TPP1
Entrez,  Source
tripeptidyl peptidase I55720.2630.3170No
101UCK2UCK2
Entrez,  Source
uridine-cytidine kinase 256310.2540.3140No
102CRLF2CRLF2
Entrez,  Source
cytokine receptor-like factor 256580.2490.3133No
103CBX4CBX4
Entrez,  Source
chromobox homolog 4 (Pc class homolog, Drosophila)58040.2250.3038No
104GTF3AGTF3A
Entrez,  Source
general transcription factor IIIA58730.2120.2999No
105NSMAFNSMAF
Entrez,  Source
neutral sphingomyelinase (N-SMase) activation associated factor59840.1990.2928No
106PITPNC1PITPNC1
Entrez,  Source
phosphatidylinositol transfer protein, cytoplasmic 161600.1710.2809No
107TLK1TLK1
Entrez,  Source
tousled-like kinase 161680.1690.2812No
108KCNK1KCNK1
Entrez,  Source
potassium channel, subfamily K, member 161990.1650.2798No
109PPP1R16BPPP1R16B
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 16B63580.1400.2689No
110MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 1365510.1110.2554No
111ARHGDIBARHGDIB
Entrez,  Source
Rho GDP dissociation inhibitor (GDI) beta69700.0430.2251No
112CTPSCTPS
Entrez,  Source
CTP synthase69830.0400.2244No
113XBP1XBP1
Entrez,  Source
X-box binding protein 172260.0060.2068No
114MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 17399-0.0210.1943No
115GALNT14GALNT14
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)7431-0.0250.1922No
116CTBP2CTBP2
Entrez,  Source
C-terminal binding protein 27439-0.0260.1918No
117HBDHBD
Entrez,  Source
hemoglobin, delta7595-0.0500.1807No
118SNTB1SNTB1
Entrez,  Source
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)7677-0.0640.1751No
119MAGEH1MAGEH1
Entrez,  Source
melanoma antigen family H, 17761-0.0770.1694No
120DNAJB9DNAJB9
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 97781-0.0810.1684No
121CAPN2CAPN2
Entrez,  Source
calpain 2, (m/II) large subunit7908-0.1020.1597No
122FLI1FLI1
Entrez,  Source
Friend leukemia virus integration 18096-0.1290.1467No
123MYBL2MYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 28116-0.1330.1459No
124P2RX5P2RX5
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 58132-0.1360.1455No
125UBE2J1UBE2J1
Entrez,  Source
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)8140-0.1370.1457No
126AUTS2AUTS2
Entrez,  Source
autism susceptibility candidate 28296-0.1630.1351No
127AVENAVEN
Entrez,  Source
apoptosis, caspase activation inhibitor8365-0.1750.1310No
128LSAMPLSAMP
Entrez,  Source
limbic system-associated membrane protein8388-0.1790.1303No
129SORDSORD
Entrez,  Source
sorbitol dehydrogenase8515-0.2010.1220No
130MAFMAF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)8583-0.2100.1182No
131NMUNMU
Entrez,  Source
neuromedin U8747-0.2370.1074No
132PDIA3PDIA3
Entrez,  Source
protein disulfide isomerase family A, member 38803-0.2480.1046No
133SLASLA
Entrez,  Source
Src-like-adaptor8858-0.2580.1019No
134PDZK1PDZK1
Entrez,  Source
PDZ domain containing 18859-0.2580.1031No
135SOX11SOX11
Entrez,  Source
SRY (sex determining region Y)-box 119094-0.2940.0875No
136EYA2EYA2
Entrez,  Source
eyes absent homolog 2 (Drosophila)9170-0.3080.0835No
137ZNF532ZNF532
Entrez,  Source
zinc finger protein 5329203-0.3110.0827No
138ST6GAL1ST6GAL1
Entrez,  Source
ST6 beta-galactosamide alpha-2,6-sialyltranferase 19231-0.3160.0822No
139CTSCCTSC
Entrez,  Source
cathepsin C9281-0.3240.0802No
140ELF1ELF1
Entrez,  Source
E74-like factor 1 (ets domain transcription factor)9321-0.3310.0790No
141GPM6BGPM6B
Entrez,  Source
glycoprotein M6B9410-0.3460.0742No
142CCPG1CCPG1
Entrez,  Source
cell cycle progression 19431-0.3500.0745No
143PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)9446-0.3530.0751No
144CTSHCTSH
Entrez,  Source
cathepsin H9512-0.3630.0722No
145SLC19A1SLC19A1
Entrez,  Source
solute carrier family 19 (folate transporter), member 19539-0.3680.0720No
146FAIMFAIM
Entrez,  Source
Fas apoptotic inhibitory molecule9681-0.3890.0636No
147DCPSDCPS
Entrez,  Source
decapping enzyme, scavenger9708-0.3920.0636No
148PRTN3PRTN3
Entrez,  Source
proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)9728-0.3960.0642No
149GTSE1GTSE1
Entrez,  Source
G-2 and S-phase expressed 19776-0.4070.0627No
150EIF5AEIF5A
Entrez,  Source
eukaryotic translation initiation factor 5A9794-0.4110.0635No
151STAG2STAG2
Entrez,  Source
stromal antigen 29884-0.4270.0590No
152IL2RGIL2RG
Entrez,  Source
interleukin 2 receptor, gamma (severe combined immunodeficiency)9911-0.4330.0592No
153NUDT1NUDT1
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 110134-0.4690.0453No
154EHD3EHD3
Entrez,  Source
EH-domain containing 310252-0.4910.0391No
155GUCY1A3GUCY1A3
Entrez,  Source
guanylate cyclase 1, soluble, alpha 310304-0.5000.0378No
156ST7ST7
Entrez,  Source
suppression of tumorigenicity 710535-0.5450.0237No
157APOBEC3BAPOBEC3B
Entrez,  Source
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B10753-0.5870.0107No
158TRAF3IP3TRAF3IP3
Entrez,  Source
TRAF3 interacting protein 310824-0.6020.0085No
159BCL2BCL2
Entrez,  Source
B-cell CLL/lymphoma 210950-0.6300.0024No
160ITGB7ITGB7
Entrez,  Source
integrin, beta 710979-0.6400.0035No
161GSTO1GSTO1
Entrez,  Source
glutathione S-transferase omega 111083-0.665-0.0008No
162DUSP6DUSP6
Entrez,  Source
dual specificity phosphatase 611119-0.676-0.0001No
163HGFHGF
Entrez,  Source
hepatocyte growth factor (hepapoietin A; scatter factor)11125-0.6780.0028No
164WHSC1WHSC1
Entrez,  Source
Wolf-Hirschhorn syndrome candidate 111331-0.733-0.0086No
165DDX17DDX17
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1711425-0.761-0.0117No
166SETSET
Entrez,  Source
SET translocation (myeloid leukemia-associated)11655-0.825-0.0245No
167BCL2L1BCL2L1
Entrez,  Source
BCL2-like 111886-0.894-0.0369No
168ANK3ANK3
Entrez,  Source
ankyrin 3, node of Ranvier (ankyrin G)11894-0.896-0.0331No
169MYBMYB
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)11984-0.928-0.0351No
170WNT5BWNT5B
Entrez,  Source
wingless-type MMTV integration site family, member 5B12140-0.981-0.0417No
171FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)12187-1.003-0.0401No
172SUMO3SUMO3
Entrez,  Source
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)12193-1.005-0.0356No
173SLC16A6SLC16A6
Entrez,  Source
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)12209-1.009-0.0318No
174ABHD14AABHD14A
Entrez,  Source
abhydrolase domain containing 14A12280-1.041-0.0319No
175CDKN1BCDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)12296-1.048-0.0279No
176PDIA4PDIA4
Entrez,  Source
protein disulfide isomerase family A, member 412320-1.057-0.0245No
177ZHX2ZHX2
Entrez,  Source
zinc fingers and homeoboxes 212456-1.116-0.0289No
178TMED1TMED1
Entrez,  Source
transmembrane emp24 protein transport domain containing 112522-1.146-0.0281No
179PSMB10PSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1012569-1.172-0.0258No
180TAPBPLTAPBPL
Entrez,  Source
TAP binding protein-like12599-1.187-0.0221No
181PHACTR2PHACTR2
Entrez,  Source
phosphatase and actin regulator 212714-1.240-0.0245No
182HDGFHDGF
Entrez,  Source
hepatoma-derived growth factor (high-mobility group protein 1-like)12769-1.267-0.0223No
183SULF1SULF1
Entrez,  Source
sulfatase 112788-1.276-0.0174No
184SDC1SDC1
Entrez,  Source
syndecan 112823-1.293-0.0136No
185SETBP1SETBP1
Entrez,  Source
SET binding protein 112881-1.332-0.0113No
186SLC38A1SLC38A1
Entrez,  Source
solute carrier family 38, member 113104-1.512-0.0202No
187PBX1PBX1
Entrez,  Source
pre-B-cell leukemia transcription factor 113142-1.551-0.0154No
188RHOHRHOH
Entrez,  Source
ras homolog gene family, member H13258-1.671-0.0157No
189S100A11S100A11
Entrez,  Source
S100 calcium binding protein A1113273-1.690-0.0085No
190ATICATIC
Entrez,  Source
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase13310-1.737-0.0027No
191ELOVL6ELOVL6
Entrez,  Source
ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)13488-1.984-0.0060No
192EMP3EMP3
Entrez,  Source
epithelial membrane protein 313574-2.167-0.0017No
193ITGB5ITGB5
Entrez,  Source
integrin, beta 513633-2.2980.0052No
194CCND1CCND1
Entrez,  Source
cyclin D113737-2.6810.0107No
Table: GSEA details [plain text format]



Fig 2: HELLER_HDAC_TARGETS_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HELLER_HDAC_TARGETS_DN: Random ES distribution   
Gene set null distribution of ES for HELLER_HDAC_TARGETS_DN