Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 4hr |
| GeneSet | KANNAN_TP53_TARGETS_UP |
| Enrichment Score (ES) | 0.54067093 |
| Normalized Enrichment Score (NES) | 1.9010139 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.46077198 |
| FWER p-Value | 0.299 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 8 | 4.549 | 0.0717 | Yes |
| 2 | PLK3 | PLK3 Entrez, Source | polo-like kinase 3 (Drosophila) | 166 | 3.348 | 0.1135 | Yes |
| 3 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 251 | 3.115 | 0.1569 | Yes |
| 4 | CES2 | CES2 Entrez, Source | carboxylesterase 2 (intestine, liver) | 323 | 2.949 | 0.1986 | Yes |
| 5 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 545 | 2.520 | 0.2226 | Yes |
| 6 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 641 | 2.387 | 0.2537 | Yes |
| 7 | PMAIP1 | PMAIP1 Entrez, Source | phorbol-12-myristate-13-acetate-induced protein 1 | 718 | 2.269 | 0.2842 | Yes |
| 8 | SLC3A2 | SLC3A2 Entrez, Source | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 723 | 2.265 | 0.3199 | Yes |
| 9 | DDB2 | DDB2 Entrez, Source | damage-specific DNA binding protein 2, 48kDa | 725 | 2.264 | 0.3558 | Yes |
| 10 | SCRIB | SCRIB Entrez, Source | scribbled homolog (Drosophila) | 933 | 2.039 | 0.3732 | Yes |
| 11 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 960 | 2.009 | 0.4033 | Yes |
| 12 | LCAT | LCAT Entrez, Source | lecithin-cholesterol acyltransferase | 973 | 1.994 | 0.4341 | Yes |
| 13 | GDF15 | GDF15 Entrez, Source | growth differentiation factor 15 | 1121 | 1.856 | 0.4529 | Yes |
| 14 | PRKAB1 | PRKAB1 Entrez, Source | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 1249 | 1.743 | 0.4714 | Yes |
| 15 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 1278 | 1.713 | 0.4966 | Yes |
| 16 | MAN2B1 | MAN2B1 Entrez, Source | mannosidase, alpha, class 2B, member 1 | 1287 | 1.707 | 0.5231 | Yes |
| 17 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 1399 | 1.610 | 0.5407 | Yes |
| 18 | ZNF7 | ZNF7 Entrez, Source | zinc finger protein 7 | 2016 | 1.211 | 0.5154 | No |
| 19 | NINJ1 | NINJ1 Entrez, Source | ninjurin 1 | 2275 | 1.089 | 0.5140 | No |
| 20 | FHL2 | FHL2 Entrez, Source | four and a half LIM domains 2 | 2505 | 0.985 | 0.5131 | No |
| 21 | APOC1 | APOC1 Entrez, Source | apolipoprotein C-I | 2824 | 0.872 | 0.5040 | No |
| 22 | SMTN | SMTN Entrez, Source | smoothelin | 3065 | 0.806 | 0.4995 | No |
| 23 | APLP1 | APLP1 Entrez, Source | amyloid beta (A4) precursor-like protein 1 | 3135 | 0.788 | 0.5070 | No |
| 24 | KIAA0247 | KIAA0247 Entrez, Source | KIAA0247 | 4570 | 0.449 | 0.4105 | No |
| 25 | DMPK | DMPK Entrez, Source | dystrophia myotonica-protein kinase | 4577 | 0.448 | 0.4172 | No |
| 26 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 5160 | 0.338 | 0.3805 | No |
| 27 | NEFL | NEFL Entrez, Source | neurofilament, light polypeptide 68kDa | 5591 | 0.261 | 0.3535 | No |
| 28 | MARCH8 | MARCH8 Entrez, Source | membrane-associated ring finger (C3HC4) 8 | 6390 | 0.135 | 0.2980 | No |
| 29 | PDLIM4 | PDLIM4 Entrez, Source | PDZ and LIM domain 4 | 6495 | 0.119 | 0.2924 | No |
| 30 | DGKA | DGKA Entrez, Source | diacylglycerol kinase, alpha 80kDa | 8134 | -0.136 | 0.1761 | No |
| 31 | ENG | ENG Entrez, Source | endoglin (Osler-Rendu-Weber syndrome 1) | 9113 | -0.297 | 0.1102 | No |
| 32 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 9188 | -0.310 | 0.1097 | No |
| 33 | SURF1 | SURF1 Entrez, Source | surfeit 1 | 9416 | -0.348 | 0.0988 | No |
| 34 | IGFBP6 | IGFBP6 Entrez, Source | insulin-like growth factor binding protein 6 | 9770 | -0.406 | 0.0798 | No |
| 35 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 9934 | -0.436 | 0.0749 | No |
| 36 | EXT2 | EXT2 Entrez, Source | exostoses (multiple) 2 | 9959 | -0.439 | 0.0802 | No |
| 37 | NHLH2 | NHLH2 Entrez, Source | nescient helix loop helix 2 | 10187 | -0.478 | 0.0714 | No |
| 38 | FEZ1 | FEZ1 Entrez, Source | fasciculation and elongation protein zeta 1 (zygin I) | 10221 | -0.484 | 0.0767 | No |
| 39 | GALE | GALE Entrez, Source | UDP-galactose-4-epimerase | 10540 | -0.546 | 0.0624 | No |
| 40 | SMAD7 | SMAD7 Entrez, Source | SMAD, mothers against DPP homolog 7 (Drosophila) | 11264 | -0.715 | 0.0215 | No |
| 41 | BAK1 | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 11849 | -0.882 | -0.0067 | No |
| 42 | BCL6 | BCL6 Entrez, Source | B-cell CLL/lymphoma 6 (zinc finger protein 51) | 12633 | -1.203 | -0.0442 | No |
| 43 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 12723 | -1.244 | -0.0309 | No |
| 44 | ABCA3 | ABCA3 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 3 | 12790 | -1.276 | -0.0154 | No |
| 45 | VIPR1 | VIPR1 Entrez, Source | vasoactive intestinal peptide receptor 1 | 12832 | -1.304 | 0.0023 | No |
| 46 | CTDSP2 | CTDSP2 Entrez, Source | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 12974 | -1.398 | 0.0144 | No |
| 47 | TAX1BP3 | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 13018 | -1.431 | 0.0340 | No |
| 48 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 13352 | -1.793 | 0.0384 | No |
