Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 0hr |
| GeneSet | BIOCARTA_PTEN_PATHWAY |
| Enrichment Score (ES) | -0.628604 |
| Normalized Enrichment Score (NES) | -1.497297 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 1706 | 1.376 | -0.0274 | No |
| 2 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 2464 | 1.000 | -0.0126 | No |
| 3 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 5297 | 0.311 | -0.1951 | No |
| 4 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 5764 | 0.231 | -0.2127 | No |
| 5 | SOS1 | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 6149 | 0.173 | -0.2284 | No |
| 6 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 6204 | 0.165 | -0.2208 | No |
| 7 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 6275 | 0.154 | -0.2151 | No |
| 8 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 7460 | -0.029 | -0.2985 | No |
| 9 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8916 | -0.266 | -0.3849 | No |
| 10 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12296 | -1.048 | -0.5558 | Yes |
| 11 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 12494 | -1.132 | -0.4914 | Yes |
| 12 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12941 | -1.374 | -0.4281 | Yes |
| 13 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 12950 | -1.382 | -0.3327 | Yes |
| 14 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 13325 | -1.754 | -0.2378 | Yes |
| 15 | ILK | ILK Entrez, Source | integrin-linked kinase | 13444 | -1.922 | -0.1127 | Yes |
| 16 | PDK2 | PDK2 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 2 | 13533 | -2.077 | 0.0252 | Yes |
