Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 4hr |
| GeneSet | KEGG_P53_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.5056842 |
| Normalized Enrichment Score (NES) | 1.8418592 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.24462096 |
| FWER p-Value | 0.259 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 8 | 4.549 | 0.0600 | Yes |
| 2 | SESN1 | SESN1 Entrez, Source | sestrin 1 | 21 | 4.244 | 0.1156 | Yes |
| 3 | MDM2 | MDM2 Entrez, Source | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | 87 | 3.712 | 0.1604 | Yes |
| 4 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 118 | 3.583 | 0.2059 | Yes |
| 5 | SESN2 | SESN2 Entrez, Source | sestrin 2 | 137 | 3.423 | 0.2502 | Yes |
| 6 | TNFRSF10B | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 177 | 3.315 | 0.2915 | Yes |
| 7 | GADD45G | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 229 | 3.167 | 0.3300 | Yes |
| 8 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 251 | 3.115 | 0.3700 | Yes |
| 9 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 460 | 2.661 | 0.3904 | Yes |
| 10 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 641 | 2.387 | 0.4091 | Yes |
| 11 | PPM1D | PPM1D Entrez, Source | protein phosphatase 1D magnesium-dependent, delta isoform | 667 | 2.354 | 0.4387 | Yes |
| 12 | PMAIP1 | PMAIP1 Entrez, Source | phorbol-12-myristate-13-acetate-induced protein 1 | 718 | 2.269 | 0.4653 | Yes |
| 13 | DDB2 | DDB2 Entrez, Source | damage-specific DNA binding protein 2, 48kDa | 725 | 2.264 | 0.4950 | Yes |
| 14 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 960 | 2.009 | 0.5048 | Yes |
| 15 | BAX | BAX Entrez, Source | BCL2-associated X protein | 1267 | 1.728 | 0.5057 | Yes |
| 16 | MDM4 | MDM4 Entrez, Source | Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) | 1712 | 1.373 | 0.4918 | No |
| 17 | STEAP3 | STEAP3 Entrez, Source | STEAP family member 3 | 2059 | 1.188 | 0.4826 | No |
| 18 | EI24 | EI24 Entrez, Source | etoposide induced 2.4 mRNA | 2566 | 0.957 | 0.4588 | No |
| 19 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 3191 | 0.771 | 0.4239 | No |
| 20 | RFWD2 | RFWD2 Entrez, Source | ring finger and WD repeat domain 2 | 3463 | 0.699 | 0.4136 | No |
| 21 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 3540 | 0.678 | 0.4171 | No |
| 22 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 3903 | 0.594 | 0.3989 | No |
| 23 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 3914 | 0.591 | 0.4060 | No |
| 24 | RRM2B | RRM2B Entrez, Source | ribonucleotide reductase M2 B (TP53 inducible) | 3932 | 0.586 | 0.4126 | No |
| 25 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 4564 | 0.450 | 0.3730 | No |
| 26 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 4787 | 0.404 | 0.3623 | No |
| 27 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 5077 | 0.352 | 0.3461 | No |
| 28 | BAI1 | BAI1 Entrez, Source | brain-specific angiogenesis inhibitor 1 | 5271 | 0.316 | 0.3363 | No |
| 29 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 5764 | 0.231 | 0.3038 | No |
| 30 | SESN3 | SESN3 Entrez, Source | sestrin 3 | 5846 | 0.218 | 0.3009 | No |
| 31 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 5890 | 0.210 | 0.3005 | No |
| 32 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 6089 | 0.183 | 0.2886 | No |
| 33 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 6696 | 0.086 | 0.2460 | No |
| 34 | TP73 | TP73 Entrez, Source | tumor protein p73 | 7406 | -0.022 | 0.1950 | No |
| 35 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 7488 | -0.033 | 0.1896 | No |
| 36 | THBS1 | THBS1 Entrez, Source | thrombospondin 1 | 8270 | -0.160 | 0.1352 | No |
| 37 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 8467 | -0.191 | 0.1236 | No |
| 38 | ATM | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 8574 | -0.209 | 0.1187 | No |
| 39 | PERP | PERP Entrez, Source | PERP, TP53 apoptosis effector | 8771 | -0.242 | 0.1077 | No |
| 40 | TP53I3 | TP53I3 Entrez, Source | tumor protein p53 inducible protein 3 | 8889 | -0.263 | 0.1028 | No |
| 41 | RPRM | RPRM Entrez, Source | reprimo, TP53 dependent G2 arrest mediator candidate | 9182 | -0.309 | 0.0858 | No |
| 42 | SIAH1 | SIAH1 Entrez, Source | seven in absentia homolog 1 (Drosophila) | 9226 | -0.315 | 0.0869 | No |
| 43 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 9494 | -0.360 | 0.0723 | No |
| 44 | RRM2 | RRM2 Entrez, Source | ribonucleotide reductase M2 polypeptide | 9674 | -0.387 | 0.0645 | No |
| 45 | GTSE1 | GTSE1 Entrez, Source | G-2 and S-phase expressed 1 | 9776 | -0.407 | 0.0627 | No |
| 46 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 9833 | -0.419 | 0.0642 | No |
| 47 | SFN | SFN Entrez, Source | stratifin | 10243 | -0.489 | 0.0411 | No |
| 48 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 10342 | -0.506 | 0.0408 | No |
| 49 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 10352 | -0.508 | 0.0469 | No |
| 50 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 11080 | -0.664 | 0.0032 | No |
| 51 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 11614 | -0.812 | -0.0246 | No |
| 52 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 12519 | -1.145 | -0.0747 | No |
| 53 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12582 | -1.177 | -0.0635 | No |
| 54 | CCNE2 | CCNE2 Entrez, Source | cyclin E2 | 12593 | -1.185 | -0.0485 | No |
| 55 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 13368 | -1.819 | -0.0802 | No |
| 56 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 13611 | -2.253 | -0.0677 | No |
| 57 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13737 | -2.681 | -0.0411 | No |
| 58 | CCNG2 | CCNG2 Entrez, Source | cyclin G2 | 13866 | -3.873 | 0.0012 | No |
