Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 4hr |
| GeneSet | KEGG_PRION_DISEASES |
| Enrichment Score (ES) | 0.6161202 |
| Normalized Enrichment Score (NES) | 1.7738844 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.20727603 |
| FWER p-Value | 0.398 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 70 | 3.808 | 0.1473 | Yes |
| 2 | NOTCH1 | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 290 | 3.026 | 0.2526 | Yes |
| 3 | PRKX | PRKX Entrez, Source | protein kinase, X-linked | 299 | 2.996 | 0.3719 | Yes |
| 4 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 643 | 2.387 | 0.4427 | Yes |
| 5 | HSPA1A | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 1071 | 1.903 | 0.4880 | Yes |
| 6 | BAX | BAX Entrez, Source | BCL2-associated X protein | 1267 | 1.728 | 0.5431 | Yes |
| 7 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 1796 | 1.333 | 0.5583 | Yes |
| 8 | HSPA5 | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 2371 | 1.043 | 0.5587 | Yes |
| 9 | STIP1 | STIP1 Entrez, Source | stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) | 2401 | 1.030 | 0.5978 | Yes |
| 10 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 2661 | 0.925 | 0.6161 | Yes |
| 11 | PRKACB | PRKACB Entrez, Source | protein kinase, cAMP-dependent, catalytic, beta | 5634 | 0.253 | 0.4119 | No |
| 12 | MAP2K2 | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 5807 | 0.224 | 0.4084 | No |
| 13 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 7146 | 0.018 | 0.3126 | No |
| 14 | EGR1 | EGR1 Entrez, Source | early growth response 1 | 7209 | 0.008 | 0.3085 | No |
| 15 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 7460 | -0.029 | 0.2916 | No |
| 16 | C8A | C8A Entrez, Source | complement component 8, alpha polypeptide | 8452 | -0.189 | 0.2277 | No |
| 17 | C8G | C8G Entrez, Source | complement component 8, gamma polypeptide | 8762 | -0.240 | 0.2150 | No |
| 18 | C7 | C7 Entrez, Source | complement component 7 | 9599 | -0.376 | 0.1697 | No |
| 19 | ELK1 | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 10463 | -0.530 | 0.1287 | No |
| 20 | PRKACA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 10715 | -0.578 | 0.1337 | No |
| 21 | C5 | C5 Entrez, Source | complement component 5 | 12166 | -0.993 | 0.0688 | No |
| 22 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12941 | -1.374 | 0.0680 | No |
