Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 0hr |
| GeneSet | KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS |
| Enrichment Score (ES) | -0.526554 |
| Normalized Enrichment Score (NES) | -1.4138219 |
| Nominal p-value | 0.103950106 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | C1S | C1S Entrez, Source | complement component 1, s subcomponent | 186 | 3.281 | 0.0312 | No |
| 2 | CD86 | CD86 Entrez, Source | CD86 molecule | 1948 | 1.247 | -0.0794 | No |
| 3 | C3 | C3 Entrez, Source | complement component 3 | 1970 | 1.236 | -0.0641 | No |
| 4 | SSB | SSB Entrez, Source | Sjogren syndrome antigen B (autoantigen La) | 2861 | 0.862 | -0.1169 | No |
| 5 | FCGR1A | FCGR1A Entrez, Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 2935 | 0.838 | -0.1108 | No |
| 6 | FCGR2A | FCGR2A Entrez, Source | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 3652 | 0.655 | -0.1537 | No |
| 7 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 3713 | 0.640 | -0.1494 | No |
| 8 | CD40 | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 3844 | 0.609 | -0.1505 | No |
| 9 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 4259 | 0.513 | -0.1735 | No |
| 10 | ACTN4 | ACTN4 Entrez, Source | actinin, alpha 4 | 4769 | 0.406 | -0.2049 | No |
| 11 | C2 | C2 Entrez, Source | complement component 2 | 5754 | 0.233 | -0.2730 | No |
| 12 | HLA-DOA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 5790 | 0.227 | -0.2725 | No |
| 13 | H2AFJ | H2AFJ Entrez, Source | H2A histone family, member J | 5815 | 0.224 | -0.2712 | No |
| 14 | H2AFB3 | H2AFB3 Entrez, Source | H2A histone family, member B3 | 6267 | 0.156 | -0.3017 | No |
| 15 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 6616 | 0.097 | -0.3256 | No |
| 16 | SNRPD3 | SNRPD3 Entrez, Source | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 6640 | 0.094 | -0.3260 | No |
| 17 | HLA-DQB1 | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 7140 | 0.018 | -0.3619 | No |
| 18 | HIST1H4B | HIST1H4B Entrez, Source | histone cluster 1, H4b | 7443 | -0.027 | -0.3835 | No |
| 19 | HIST1H4L | HIST1H4L Entrez, Source | histone cluster 1, H4l | 7742 | -0.074 | -0.4041 | No |
| 20 | SNRPD1 | SNRPD1 Entrez, Source | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 7851 | -0.093 | -0.4106 | No |
| 21 | TRIM21 | TRIM21 Entrez, Source | tripartite motif-containing 21 | 7931 | -0.105 | -0.4149 | No |
| 22 | HIST1H2AB | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 7964 | -0.111 | -0.4157 | No |
| 23 | HIST1H4D | HIST1H4D Entrez, Source | histone cluster 1, H4d | 7967 | -0.111 | -0.4144 | No |
| 24 | HIST1H4C | HIST1H4C Entrez, Source | histone cluster 1, H4c | 8192 | -0.144 | -0.4286 | No |
| 25 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 8202 | -0.145 | -0.4273 | No |
| 26 | C8A | C8A Entrez, Source | complement component 8, alpha polypeptide | 8452 | -0.189 | -0.4428 | No |
| 27 | HLA-DOB | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 8665 | -0.222 | -0.4551 | No |
| 28 | HLA-DRB1 | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8729 | -0.234 | -0.4565 | No |
| 29 | C8G | C8G Entrez, Source | complement component 8, gamma polypeptide | 8762 | -0.240 | -0.4555 | No |
| 30 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 9211 | -0.313 | -0.4837 | No |
| 31 | HIST2H2AB | HIST2H2AB Entrez, Source | histone cluster 2, H2ab | 9268 | -0.323 | -0.4834 | No |
| 32 | C7 | C7 Entrez, Source | complement component 7 | 9599 | -0.376 | -0.5022 | No |
| 33 | H2AFY | H2AFY Entrez, Source | H2A histone family, member Y | 9746 | -0.400 | -0.5073 | No |
| 34 | SNRPB | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 9853 | -0.422 | -0.5093 | No |
| 35 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 9862 | -0.423 | -0.5041 | No |
| 36 | HIST1H2AL | HIST1H2AL Entrez, Source | histone cluster 1, H2al | 9888 | -0.428 | -0.5001 | No |
| 37 | C4A | C4A Entrez, Source | complement component 4A (Rodgers blood group) | 9891 | -0.429 | -0.4944 | No |
| 38 | HIST1H4J | HIST1H4J Entrez, Source | histone cluster 1, H4j | 9894 | -0.429 | -0.4887 | No |
| 39 | HIST1H3I | HIST1H3I Entrez, Source | histone cluster 1, H3i | 9930 | -0.436 | -0.4853 | No |
| 40 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 9934 | -0.436 | -0.4795 | No |
| 41 | CTSG | CTSG Entrez, Source | cathepsin G | 10095 | -0.463 | -0.4848 | No |
| 42 | HIST1H4K | HIST1H4K Entrez, Source | histone cluster 1, H4k | 10258 | -0.492 | -0.4899 | No |
| 43 | ACTN3 | ACTN3 Entrez, Source | actinin, alpha 3 | 10273 | -0.494 | -0.4841 | No |
| 44 | HLA-DQA1 | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 10308 | -0.501 | -0.4798 | No |
| 45 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 10386 | -0.513 | -0.4784 | No |
| 46 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 10844 | -0.607 | -0.5032 | No |
| 47 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 11091 | -0.667 | -0.5120 | No |
| 48 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 11293 | -0.724 | -0.5167 | Yes |
| 49 | HIST1H4F | HIST1H4F Entrez, Source | histone cluster 1, H4f | 11324 | -0.732 | -0.5089 | Yes |
| 50 | HLA-DPA1 | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 11402 | -0.754 | -0.5042 | Yes |
| 51 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 11464 | -0.772 | -0.4981 | Yes |
| 52 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 11467 | -0.772 | -0.4877 | Yes |
| 53 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 11620 | -0.813 | -0.4877 | Yes |
| 54 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 11662 | -0.826 | -0.4794 | Yes |
| 55 | HIST1H3C | HIST1H3C Entrez, Source | histone cluster 1, H3c | 11700 | -0.836 | -0.4707 | Yes |
| 56 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 11752 | -0.851 | -0.4628 | Yes |
| 57 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 11753 | -0.852 | -0.4511 | Yes |
| 58 | HLA-DMA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 11761 | -0.855 | -0.4400 | Yes |
| 59 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 11912 | -0.903 | -0.4386 | Yes |
| 60 | HIST3H3 | HIST3H3 Entrez, Source | histone cluster 3, H3 | 11980 | -0.927 | -0.4308 | Yes |
| 61 | HIST1H2BM | HIST1H2BM Entrez, Source | histone cluster 1, H2bm | 11993 | -0.930 | -0.4190 | Yes |
| 62 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 12011 | -0.935 | -0.4075 | Yes |
| 63 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 12051 | -0.951 | -0.3974 | Yes |
| 64 | C5 | C5 Entrez, Source | complement component 5 | 12166 | -0.993 | -0.3921 | Yes |
| 65 | HIST1H4A | HIST1H4A Entrez, Source | histone cluster 1, H4a | 12181 | -1.002 | -0.3795 | Yes |
| 66 | HIST1H2AG | HIST1H2AG Entrez, Source | histone cluster 1, H2ag | 12228 | -1.017 | -0.3689 | Yes |
| 67 | HIST1H3F | HIST1H3F Entrez, Source | histone cluster 1, H3f | 12289 | -1.045 | -0.3590 | Yes |
| 68 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 12383 | -1.082 | -0.3510 | Yes |
| 69 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 12394 | -1.088 | -0.3369 | Yes |
| 70 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 12419 | -1.099 | -0.3237 | Yes |
| 71 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 12448 | -1.111 | -0.3106 | Yes |
| 72 | H2AFY2 | H2AFY2 Entrez, Source | H2A histone family, member Y2 | 12457 | -1.117 | -0.2959 | Yes |
| 73 | HIST1H2AD | HIST1H2AD Entrez, Source | histone cluster 1, H2ad | 12471 | -1.123 | -0.2816 | Yes |
| 74 | H2AFV | H2AFV Entrez, Source | H2A histone family, member V | 12475 | -1.124 | -0.2665 | Yes |
| 75 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12692 | -1.226 | -0.2654 | Yes |
| 76 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 12705 | -1.235 | -0.2494 | Yes |
| 77 | HIST3H2A | HIST3H2A Entrez, Source | histone cluster 3, H2a | 12752 | -1.259 | -0.2356 | Yes |
| 78 | HIST1H2AJ | HIST1H2AJ Entrez, Source | histone cluster 1, H2aj | 12817 | -1.290 | -0.2227 | Yes |
| 79 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 12862 | -1.324 | -0.2078 | Yes |
| 80 | HIST1H2AH | HIST1H2AH Entrez, Source | histone cluster 1, H2ah | 13029 | -1.444 | -0.2002 | Yes |
| 81 | HLA-DRB5 | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 13134 | -1.541 | -0.1867 | Yes |
| 82 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 13190 | -1.598 | -0.1689 | Yes |
| 83 | HLA-DPB1 | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 13246 | -1.659 | -0.1503 | Yes |
| 84 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 13453 | -1.932 | -0.1389 | Yes |
| 85 | HIST2H3C | HIST2H3C Entrez, Source | histone cluster 2, H3c | 13476 | -1.964 | -0.1138 | Yes |
| 86 | HIST1H2AK | HIST1H2AK Entrez, Source | histone cluster 1, H2ak | 13482 | -1.976 | -0.0872 | Yes |
| 87 | HIST1H2AM | HIST1H2AM Entrez, Source | histone cluster 1, H2am | 13618 | -2.264 | -0.0661 | Yes |
| 88 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 13658 | -2.369 | -0.0367 | Yes |
| 89 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 13867 | -3.883 | 0.0012 | Yes |
