Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 4hr |
| GeneSet | PID_P53_DOWNSTREAM_PATHWAY |
| Enrichment Score (ES) | 0.50435925 |
| Normalized Enrichment Score (NES) | 1.979078 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.30878836 |
| FWER p-Value | 0.167 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 8 | 4.549 | 0.0345 | Yes |
| 2 | SESN1 | SESN1 Entrez, Source | sestrin 1 | 21 | 4.244 | 0.0663 | Yes |
| 3 | MDM2 | MDM2 Entrez, Source | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | 87 | 3.712 | 0.0902 | Yes |
| 4 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 118 | 3.583 | 0.1157 | Yes |
| 5 | PLK3 | PLK3 Entrez, Source | polo-like kinase 3 (Drosophila) | 166 | 3.348 | 0.1381 | Yes |
| 6 | CEBPZ | CEBPZ Entrez, Source | CCAAT/enhancer binding protein zeta | 172 | 3.335 | 0.1634 | Yes |
| 7 | TNFRSF10B | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 177 | 3.315 | 0.1887 | Yes |
| 8 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 251 | 3.115 | 0.2074 | Yes |
| 9 | TNFRSF10C | TNFRSF10C Entrez, Source | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 311 | 2.976 | 0.2261 | Yes |
| 10 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 363 | 2.852 | 0.2443 | Yes |
| 11 | E2F3 | E2F3 Entrez, Source | E2F transcription factor 3 | 418 | 2.738 | 0.2615 | Yes |
| 12 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 545 | 2.520 | 0.2718 | Yes |
| 13 | TNFRSF10A | TNFRSF10A Entrez, Source | tumor necrosis factor receptor superfamily, member 10a | 619 | 2.416 | 0.2851 | Yes |
| 14 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 641 | 2.387 | 0.3020 | Yes |
| 15 | PMAIP1 | PMAIP1 Entrez, Source | phorbol-12-myristate-13-acetate-induced protein 1 | 718 | 2.269 | 0.3140 | Yes |
| 16 | DDB2 | DDB2 Entrez, Source | damage-specific DNA binding protein 2, 48kDa | 725 | 2.264 | 0.3310 | Yes |
| 17 | CCNK | CCNK Entrez, Source | cyclin K | 729 | 2.258 | 0.3482 | Yes |
| 18 | PPP1R13B | PPP1R13B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 13B | 786 | 2.199 | 0.3611 | Yes |
| 19 | TP53INP1 | TP53INP1 Entrez, Source | tumor protein p53 inducible nuclear protein 1 | 831 | 2.142 | 0.3744 | Yes |
| 20 | LIF | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 867 | 2.106 | 0.3881 | Yes |
| 21 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 960 | 2.009 | 0.3969 | Yes |
| 22 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 975 | 1.993 | 0.4112 | Yes |
| 23 | IRF5 | IRF5 Entrez, Source | interferon regulatory factor 5 | 1054 | 1.919 | 0.4204 | Yes |
| 24 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 1095 | 1.884 | 0.4320 | Yes |
| 25 | GDF15 | GDF15 Entrez, Source | growth differentiation factor 15 | 1121 | 1.856 | 0.4445 | Yes |
| 26 | PRKAB1 | PRKAB1 Entrez, Source | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 1249 | 1.743 | 0.4487 | Yes |
| 27 | BAX | BAX Entrez, Source | BCL2-associated X protein | 1267 | 1.728 | 0.4608 | Yes |
| 28 | DUSP1 | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 1329 | 1.670 | 0.4692 | Yes |
| 29 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 1399 | 1.610 | 0.4766 | Yes |
| 30 | RPS27L | RPS27L Entrez, Source | ribosomal protein S27-like | 1443 | 1.570 | 0.4856 | Yes |
| 31 | PML | PML Entrez, Source | promyelocytic leukemia | 1493 | 1.522 | 0.4938 | Yes |
| 32 | JMY | JMY Entrez, Source | - | 1509 | 1.511 | 0.5044 | Yes |
| 33 | CASP10 | CASP10 Entrez, Source | caspase 10, apoptosis-related cysteine peptidase | 1741 | 1.357 | 0.4981 | No |
| 34 | STEAP3 | STEAP3 Entrez, Source | STEAP family member 3 | 2059 | 1.188 | 0.4842 | No |
| 35 | S100A2 | S100A2 Entrez, Source | S100 calcium binding protein A2 | 2136 | 1.153 | 0.4876 | No |
| 36 | DUSP5 | DUSP5 Entrez, Source | dual specificity phosphatase 5 | 2450 | 1.010 | 0.4726 | No |
| 37 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 2469 | 0.998 | 0.4790 | No |
| 38 | JUN | JUN Entrez, Source | jun oncogene | 2550 | 0.961 | 0.4806 | No |
| 39 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 2644 | 0.931 | 0.4811 | No |
| 40 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2652 | 0.928 | 0.4877 | No |
| 41 | TP53BP2 | TP53BP2 Entrez, Source | tumor protein p53 binding protein, 2 | 2829 | 0.871 | 0.4816 | No |
| 42 | VDR | VDR Entrez, Source | vitamin D (1,25- dihydroxyvitamin D3) receptor | 2959 | 0.832 | 0.4787 | No |
| 43 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 3044 | 0.811 | 0.4789 | No |
| 44 | PMS2 | PMS2 Entrez, Source | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 3052 | 0.808 | 0.4846 | No |
| 45 | TAF9 | TAF9 Entrez, Source | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa | 3158 | 0.782 | 0.4830 | No |
| 46 | TAP1 | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 3458 | 0.700 | 0.4667 | No |
| 47 | RFWD2 | RFWD2 Entrez, Source | ring finger and WD repeat domain 2 | 3463 | 0.699 | 0.4718 | No |
| 48 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 3540 | 0.678 | 0.4715 | No |
| 49 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 3893 | 0.596 | 0.4505 | No |
| 50 | RRM2B | RRM2B Entrez, Source | ribonucleotide reductase M2 B (TP53 inducible) | 3932 | 0.586 | 0.4523 | No |
| 51 | MLH1 | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 4116 | 0.545 | 0.4432 | No |
| 52 | MAP4K4 | MAP4K4 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 4 | 4531 | 0.458 | 0.4167 | No |
| 53 | PPM1J | PPM1J Entrez, Source | protein phosphatase 1J (PP2C domain containing) | 4994 | 0.366 | 0.3860 | No |
| 54 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 5046 | 0.358 | 0.3851 | No |
| 55 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 5077 | 0.352 | 0.3856 | No |
| 56 | NFYA | NFYA Entrez, Source | nuclear transcription factor Y, alpha | 5107 | 0.346 | 0.3862 | No |
| 57 | MCL1 | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 5240 | 0.321 | 0.3790 | No |
| 58 | GPX1 | GPX1 Entrez, Source | glutathione peroxidase 1 | 5294 | 0.312 | 0.3776 | No |
| 59 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 5764 | 0.231 | 0.3453 | No |
| 60 | COL18A1 | COL18A1 Entrez, Source | collagen, type XVIII, alpha 1 | 5928 | 0.206 | 0.3351 | No |
| 61 | EPHA2 | EPHA2 Entrez, Source | EPH receptor A2 | 6094 | 0.182 | 0.3245 | No |
| 62 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 6696 | 0.086 | 0.2816 | No |
| 63 | BCL2L2 | BCL2L2 Entrez, Source | BCL2-like 2 | 7021 | 0.034 | 0.2583 | No |
| 64 | TP73 | TP73 Entrez, Source | tumor protein p73 | 7406 | -0.022 | 0.2306 | No |
| 65 | EDN2 | EDN2 Entrez, Source | endothelin 2 | 7424 | -0.025 | 0.2296 | No |
| 66 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 7488 | -0.033 | 0.2253 | No |
| 67 | CSE1L | CSE1L Entrez, Source | CSE1 chromosome segregation 1-like (yeast) | 7550 | -0.043 | 0.2212 | No |
| 68 | NFYC | NFYC Entrez, Source | nuclear transcription factor Y, gamma | 7790 | -0.082 | 0.2045 | No |
| 69 | BCL2L14 | BCL2L14 Entrez, Source | BCL2-like 14 (apoptosis facilitator) | 8218 | -0.149 | 0.1746 | No |
| 70 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 8467 | -0.191 | 0.1581 | No |
| 71 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 8497 | -0.197 | 0.1575 | No |
| 72 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 8526 | -0.203 | 0.1570 | No |
| 73 | PERP | PERP Entrez, Source | PERP, TP53 apoptosis effector | 8771 | -0.242 | 0.1412 | No |
| 74 | TP53I3 | TP53I3 Entrez, Source | tumor protein p53 inducible protein 3 | 8889 | -0.263 | 0.1347 | No |
| 75 | PCBP4 | PCBP4 Entrez, Source | poly(rC) binding protein 4 | 8947 | -0.271 | 0.1327 | No |
| 76 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 9191 | -0.310 | 0.1174 | No |
| 77 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 9494 | -0.360 | 0.0983 | No |
| 78 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 9833 | -0.419 | 0.0770 | No |
| 79 | TFDP1 | TFDP1 Entrez, Source | transcription factor Dp-1 | 9876 | -0.426 | 0.0772 | No |
| 80 | TRRAP | TRRAP Entrez, Source | transformation/transcription domain-associated protein | 9900 | -0.430 | 0.0789 | No |
| 81 | SFN | SFN Entrez, Source | stratifin | 10243 | -0.489 | 0.0578 | No |
| 82 | BNIP3L | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 10666 | -0.568 | 0.0316 | No |
| 83 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 10950 | -0.630 | 0.0159 | No |
| 84 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 10974 | -0.639 | 0.0192 | No |
| 85 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 11125 | -0.678 | 0.0135 | No |
| 86 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 11267 | -0.716 | 0.0088 | No |
| 87 | SP1 | SP1 Entrez, Source | Sp1 transcription factor | 11308 | -0.728 | 0.0115 | No |
| 88 | FOXA1 | FOXA1 Entrez, Source | forkhead box A1 | 11365 | -0.743 | 0.0132 | No |
| 89 | NFYB | NFYB Entrez, Source | nuclear transcription factor Y, beta | 11699 | -0.836 | -0.0046 | No |
| 90 | DDX5 | DDX5 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 11783 | -0.862 | -0.0039 | No |
| 91 | BAK1 | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 11849 | -0.882 | -0.0019 | No |
| 92 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 11886 | -0.894 | 0.0024 | No |
| 93 | SNAI2 | SNAI2 Entrez, Source | snail homolog 2 (Drosophila) | 11931 | -0.910 | 0.0062 | No |
| 94 | CASP6 | CASP6 Entrez, Source | caspase 6, apoptosis-related cysteine peptidase | 12169 | -0.996 | -0.0033 | No |
| 95 | E2F2 | E2F2 Entrez, Source | E2F transcription factor 2 | 12250 | -1.028 | -0.0012 | No |
| 96 | PYCARD | PYCARD Entrez, Source | PYD and CARD domain containing | 12263 | -1.033 | 0.0059 | No |
| 97 | APC | APC Entrez, Source | adenomatosis polyposis coli | 12432 | -1.105 | 0.0022 | No |
| 98 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 12519 | -1.145 | 0.0048 | No |
| 99 | BCL6 | BCL6 Entrez, Source | B-cell CLL/lymphoma 6 (zinc finger protein 51) | 12633 | -1.203 | 0.0059 | No |
| 100 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 12723 | -1.244 | 0.0090 | No |
| 101 | DKK1 | DKK1 Entrez, Source | dickkopf homolog 1 (Xenopus laevis) | 12779 | -1.270 | 0.0148 | No |
| 102 | SMARCA4 | SMARCA4 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 13355 | -1.797 | -0.0130 | No |
| 103 | ARID3A | ARID3A Entrez, Source | AT rich interactive domain 3A (BRIGHT- like) | 13465 | -1.951 | -0.0059 | No |
| 104 | DGCR8 | DGCR8 Entrez, Source | DiGeorge syndrome critical region gene 8 | 13603 | -2.239 | 0.0014 | No |
| 105 | MSH2 | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 13685 | -2.444 | 0.0144 | No |
