Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 4hr |
| GeneSet | PID_TAP63_PATHWAY |
| Enrichment Score (ES) | 0.48202088 |
| Normalized Enrichment Score (NES) | 1.7929893 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.21774855 |
| FWER p-Value | 0.352 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 8 | 4.549 | 0.0779 | Yes |
| 2 | MDM2 | MDM2 Entrez, Source | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | 87 | 3.712 | 0.1363 | Yes |
| 3 | GPX2 | GPX2 Entrez, Source | glutathione peroxidase 2 (gastrointestinal) | 210 | 3.208 | 0.1828 | Yes |
| 4 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 251 | 3.115 | 0.2337 | Yes |
| 5 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 363 | 2.852 | 0.2749 | Yes |
| 6 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 641 | 2.387 | 0.2960 | Yes |
| 7 | PMAIP1 | PMAIP1 Entrez, Source | phorbol-12-myristate-13-acetate-induced protein 1 | 718 | 2.269 | 0.3297 | Yes |
| 8 | TRAF4 | TRAF4 Entrez, Source | TNF receptor-associated factor 4 | 957 | 2.013 | 0.3472 | Yes |
| 9 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 960 | 2.009 | 0.3817 | Yes |
| 10 | GDF15 | GDF15 Entrez, Source | growth differentiation factor 15 | 1121 | 1.856 | 0.4022 | Yes |
| 11 | ITCH | ITCH Entrez, Source | itchy homolog E3 ubiquitin protein ligase (mouse) | 1220 | 1.760 | 0.4254 | Yes |
| 12 | BAX | BAX Entrez, Source | BCL2-associated X protein | 1267 | 1.728 | 0.4519 | Yes |
| 13 | PML | PML Entrez, Source | promyelocytic leukemia | 1493 | 1.522 | 0.4619 | Yes |
| 14 | ADA | ADA Entrez, Source | adenosine deaminase | 1567 | 1.472 | 0.4820 | Yes |
| 15 | NOC2L | NOC2L Entrez, Source | nucleolar complex associated 2 homolog (S. cerevisiae) | 2044 | 1.194 | 0.4682 | No |
| 16 | S100A2 | S100A2 Entrez, Source | S100 calcium binding protein A2 | 2136 | 1.153 | 0.4815 | No |
| 17 | ABL1 | ABL1 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 2475 | 0.996 | 0.4743 | No |
| 18 | VDR | VDR Entrez, Source | vitamin D (1,25- dihydroxyvitamin D3) receptor | 2959 | 0.832 | 0.4537 | No |
| 19 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 3596 | 0.666 | 0.4192 | No |
| 20 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 3903 | 0.594 | 0.4074 | No |
| 21 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 5155 | 0.338 | 0.3228 | No |
| 22 | SHH | SHH Entrez, Source | sonic hedgehog homolog (Drosophila) | 5810 | 0.224 | 0.2794 | No |
| 23 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 6230 | 0.162 | 0.2519 | No |
| 24 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 6669 | 0.089 | 0.2218 | No |
| 25 | CHUK | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 7307 | -0.006 | 0.1758 | No |
| 26 | OGG1 | OGG1 Entrez, Source | 8-oxoguanine DNA glycosylase | 7422 | -0.024 | 0.1680 | No |
| 27 | YWHAQ | YWHAQ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 7611 | -0.052 | 0.1553 | No |
| 28 | SMARCD3 | SMARCD3 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 8042 | -0.122 | 0.1264 | No |
| 29 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 8467 | -0.191 | 0.0990 | No |
| 30 | PERP | PERP Entrez, Source | PERP, TP53 apoptosis effector | 8771 | -0.242 | 0.0813 | No |
| 31 | TP53I3 | TP53I3 Entrez, Source | tumor protein p53 inducible protein 3 | 8889 | -0.263 | 0.0774 | No |
| 32 | EVPL | EVPL Entrez, Source | envoplakin | 8987 | -0.278 | 0.0751 | No |
| 33 | EGR2 | EGR2 Entrez, Source | early growth response 2 (Krox-20 homolog, Drosophila) | 9133 | -0.301 | 0.0699 | No |
| 34 | SSRP1 | SSRP1 Entrez, Source | structure specific recognition protein 1 | 9421 | -0.349 | 0.0551 | No |
| 35 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 9446 | -0.353 | 0.0595 | No |
| 36 | DICER1 | DICER1 Entrez, Source | Dicer1, Dcr-1 homolog (Drosophila) | 10000 | -0.447 | 0.0272 | No |
| 37 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 10359 | -0.509 | 0.0101 | No |
| 38 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 10974 | -0.639 | -0.0232 | No |
| 39 | SP1 | SP1 Entrez, Source | Sp1 transcription factor | 11308 | -0.728 | -0.0347 | No |
| 40 | TFAP2C | TFAP2C Entrez, Source | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 11325 | -0.732 | -0.0233 | No |
| 41 | WWP1 | WWP1 Entrez, Source | WW domain containing E3 ubiquitin protein ligase 1 | 12349 | -1.070 | -0.0787 | No |
| 42 | HBP1 | HBP1 Entrez, Source | HMG-box transcription factor 1 | 12514 | -1.142 | -0.0709 | No |
| 43 | ITGA3 | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 12734 | -1.248 | -0.0652 | No |
| 44 | DST | DST Entrez, Source | dystonin | 13097 | -1.508 | -0.0653 | No |
| 45 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 13181 | -1.589 | -0.0439 | No |
| 46 | FLOT2 | FLOT2 Entrez, Source | flotillin 2 | 13250 | -1.665 | -0.0201 | No |
| 47 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 13341 | -1.778 | 0.0041 | No |
| 48 | CABLES1 | CABLES1 Entrez, Source | Cdk5 and Abl enzyme substrate 1 | 13508 | -2.031 | 0.0271 | No |
