Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 4hr |
| GeneSet | PID_TRAIL_PATHWAY |
| Enrichment Score (ES) | 0.6141709 |
| Normalized Enrichment Score (NES) | 1.8885359 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.20310465 |
| FWER p-Value | 0.259 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 98 | 3.658 | 0.0906 | Yes |
| 2 | RIPK1 | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 119 | 3.562 | 0.1843 | Yes |
| 3 | TNFRSF10B | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 177 | 3.315 | 0.2688 | Yes |
| 4 | TNFRSF10C | TNFRSF10C Entrez, Source | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 311 | 2.976 | 0.3386 | Yes |
| 5 | DAP3 | DAP3 Entrez, Source | death associated protein 3 | 314 | 2.967 | 0.4177 | Yes |
| 6 | IKBKG | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 449 | 2.686 | 0.4798 | Yes |
| 7 | TNFRSF10A | TNFRSF10A Entrez, Source | tumor necrosis factor receptor superfamily, member 10a | 619 | 2.416 | 0.5322 | Yes |
| 8 | PIK3CD | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 795 | 2.181 | 0.5778 | Yes |
| 9 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 1016 | 1.957 | 0.6142 | Yes |
| 10 | CASP10 | CASP10 Entrez, Source | caspase 10, apoptosis-related cysteine peptidase | 1741 | 1.357 | 0.5982 | No |
| 11 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 4358 | 0.493 | 0.4226 | No |
| 12 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 4787 | 0.404 | 0.4025 | No |
| 13 | MAPK8 | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 5109 | 0.346 | 0.3885 | No |
| 14 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 5155 | 0.338 | 0.3943 | No |
| 15 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5247 | 0.320 | 0.3963 | No |
| 16 | CHUK | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 7307 | -0.006 | 0.2479 | No |
| 17 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 7460 | -0.029 | 0.2377 | No |
| 18 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8916 | -0.266 | 0.1398 | No |
| 19 | TRADD | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 9409 | -0.346 | 0.1136 | No |
| 20 | SMPD1 | SMPD1 Entrez, Source | sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) | 9890 | -0.428 | 0.0904 | No |
| 21 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 10970 | -0.637 | 0.0295 | No |
| 22 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 12494 | -1.132 | -0.0501 | No |
| 23 | TNFSF10 | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 12744 | -1.255 | -0.0346 | No |
| 24 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12941 | -1.374 | -0.0120 | No |
| 25 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 13797 | -2.993 | 0.0062 | No |
