Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 0hr |
| GeneSet | REACTOME_AMYLOIDS |
| Enrichment Score (ES) | -0.66108894 |
| Normalized Enrichment Score (NES) | -1.5793871 |
| Nominal p-value | 0.10288066 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.839 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ITM2B | ITM2B Entrez, Source | integral membrane protein 2B | 4124 | 0.544 | -0.2862 | No |
| 2 | B2M | B2M Entrez, Source | beta-2-microglobulin | 4854 | 0.391 | -0.3302 | No |
| 3 | APCS | APCS Entrez, Source | amyloid P component, serum | 5215 | 0.327 | -0.3490 | No |
| 4 | IAPP | IAPP Entrez, Source | islet amyloid polypeptide | 6209 | 0.164 | -0.4172 | No |
| 5 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 6616 | 0.097 | -0.4444 | No |
| 6 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 6669 | 0.089 | -0.4461 | No |
| 7 | CALCA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 6947 | 0.048 | -0.4651 | No |
| 8 | INS | INS Entrez, Source | insulin | 7243 | 0.004 | -0.4864 | No |
| 9 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 7246 | 0.003 | -0.4864 | No |
| 10 | HIST1H4B | HIST1H4B Entrez, Source | histone cluster 1, H4b | 7443 | -0.027 | -0.5000 | No |
| 11 | HIST1H4L | HIST1H4L Entrez, Source | histone cluster 1, H4l | 7742 | -0.074 | -0.5199 | No |
| 12 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 7929 | -0.105 | -0.5310 | No |
| 13 | HIST1H2AB | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 7964 | -0.111 | -0.5310 | No |
| 14 | HIST1H4D | HIST1H4D Entrez, Source | histone cluster 1, H4d | 7967 | -0.111 | -0.5287 | No |
| 15 | HIST1H4C | HIST1H4C Entrez, Source | histone cluster 1, H4c | 8192 | -0.144 | -0.5417 | No |
| 16 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 8202 | -0.145 | -0.5391 | No |
| 17 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 9862 | -0.423 | -0.6497 | Yes |
| 18 | HIST1H4J | HIST1H4J Entrez, Source | histone cluster 1, H4j | 9894 | -0.429 | -0.6424 | Yes |
| 19 | HIST1H3I | HIST1H3I Entrez, Source | histone cluster 1, H3i | 9930 | -0.436 | -0.6353 | Yes |
| 20 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 9934 | -0.436 | -0.6258 | Yes |
| 21 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 10214 | -0.483 | -0.6353 | Yes |
| 22 | HIST1H4K | HIST1H4K Entrez, Source | histone cluster 1, H4k | 10258 | -0.492 | -0.6275 | Yes |
| 23 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 10386 | -0.513 | -0.6252 | Yes |
| 24 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 10844 | -0.607 | -0.6448 | Yes |
| 25 | HSPG2 | HSPG2 Entrez, Source | heparan sulfate proteoglycan 2 (perlecan) | 11070 | -0.660 | -0.6464 | Yes |
| 26 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 11091 | -0.667 | -0.6331 | Yes |
| 27 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 11293 | -0.724 | -0.6315 | Yes |
| 28 | HIST1H4F | HIST1H4F Entrez, Source | histone cluster 1, H4f | 11324 | -0.732 | -0.6174 | Yes |
| 29 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 11464 | -0.772 | -0.6103 | Yes |
| 30 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 11467 | -0.772 | -0.5933 | Yes |
| 31 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 11620 | -0.813 | -0.5862 | Yes |
| 32 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 11662 | -0.826 | -0.5709 | Yes |
| 33 | HIST1H3C | HIST1H3C Entrez, Source | histone cluster 1, H3c | 11700 | -0.836 | -0.5550 | Yes |
| 34 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 11752 | -0.851 | -0.5397 | Yes |
| 35 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 11753 | -0.852 | -0.5208 | Yes |
| 36 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 11912 | -0.903 | -0.5122 | Yes |
| 37 | HIST1H2BM | HIST1H2BM Entrez, Source | histone cluster 1, H2bm | 11993 | -0.930 | -0.4973 | Yes |
| 38 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 12011 | -0.935 | -0.4778 | Yes |
| 39 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 12051 | -0.951 | -0.4595 | Yes |
| 40 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12071 | -0.957 | -0.4396 | Yes |
| 41 | HIST1H4A | HIST1H4A Entrez, Source | histone cluster 1, H4a | 12181 | -1.002 | -0.4252 | Yes |
| 42 | HIST1H3F | HIST1H3F Entrez, Source | histone cluster 1, H3f | 12289 | -1.045 | -0.4097 | Yes |
| 43 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 12383 | -1.082 | -0.3924 | Yes |
| 44 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 12394 | -1.088 | -0.3689 | Yes |
| 45 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 12419 | -1.099 | -0.3463 | Yes |
| 46 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 12448 | -1.111 | -0.3236 | Yes |
| 47 | HIST1H2AD | HIST1H2AD Entrez, Source | histone cluster 1, H2ad | 12471 | -1.123 | -0.3002 | Yes |
| 48 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12692 | -1.226 | -0.2889 | Yes |
| 49 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 12705 | -1.235 | -0.2623 | Yes |
| 50 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 12753 | -1.260 | -0.2378 | Yes |
| 51 | HIST1H2AJ | HIST1H2AJ Entrez, Source | histone cluster 1, H2aj | 12817 | -1.290 | -0.2137 | Yes |
| 52 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 12862 | -1.324 | -0.1874 | Yes |
| 53 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 13190 | -1.598 | -0.1756 | Yes |
| 54 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 13453 | -1.932 | -0.1516 | Yes |
| 55 | HIST2H3C | HIST2H3C Entrez, Source | histone cluster 2, H3c | 13476 | -1.964 | -0.1096 | Yes |
| 56 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 13658 | -2.369 | -0.0701 | Yes |
| 57 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 13867 | -3.883 | 0.0012 | Yes |
