Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 0hr |
| GeneSet | REACTOME_MEIOTIC_RECOMBINATION |
| Enrichment Score (ES) | -0.6051574 |
| Normalized Enrichment Score (NES) | -1.3861734 |
| Nominal p-value | 0.21205822 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RBBP8 | RBBP8 Entrez, Source | retinoblastoma binding protein 8 | 365 | 2.850 | 0.0256 | No |
| 2 | PRDM9 | PRDM9 Entrez, Source | PR domain containing 9 | 2189 | 1.133 | -0.0857 | No |
| 3 | MLH1 | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 4116 | 0.545 | -0.2151 | No |
| 4 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 6616 | 0.097 | -0.3941 | No |
| 5 | HIST1H4B | HIST1H4B Entrez, Source | histone cluster 1, H4b | 7443 | -0.027 | -0.4534 | No |
| 6 | HIST1H4L | HIST1H4L Entrez, Source | histone cluster 1, H4l | 7742 | -0.074 | -0.4736 | No |
| 7 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 7882 | -0.097 | -0.4819 | No |
| 8 | HIST1H2AB | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 7964 | -0.111 | -0.4857 | No |
| 9 | HIST1H4D | HIST1H4D Entrez, Source | histone cluster 1, H4d | 7967 | -0.111 | -0.4839 | No |
| 10 | HIST1H4C | HIST1H4C Entrez, Source | histone cluster 1, H4c | 8192 | -0.144 | -0.4974 | No |
| 11 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 8202 | -0.145 | -0.4954 | No |
| 12 | BLM | BLM Entrez, Source | Bloom syndrome | 8540 | -0.205 | -0.5161 | No |
| 13 | MRE11A | MRE11A Entrez, Source | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 8573 | -0.209 | -0.5146 | No |
| 14 | ATM | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 8574 | -0.209 | -0.5108 | No |
| 15 | RAD51 | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 9156 | -0.305 | -0.5472 | No |
| 16 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 9640 | -0.383 | -0.5752 | No |
| 17 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 9862 | -0.423 | -0.5835 | No |
| 18 | HIST1H4J | HIST1H4J Entrez, Source | histone cluster 1, H4j | 9894 | -0.429 | -0.5779 | No |
| 19 | HIST1H3I | HIST1H3I Entrez, Source | histone cluster 1, H3i | 9930 | -0.436 | -0.5725 | No |
| 20 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 9934 | -0.436 | -0.5647 | No |
| 21 | HIST1H4K | HIST1H4K Entrez, Source | histone cluster 1, H4k | 10258 | -0.492 | -0.5791 | No |
| 22 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 10386 | -0.513 | -0.5790 | No |
| 23 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 10749 | -0.586 | -0.5945 | Yes |
| 24 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 10844 | -0.607 | -0.5902 | Yes |
| 25 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 11004 | -0.645 | -0.5899 | Yes |
| 26 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 11080 | -0.664 | -0.5832 | Yes |
| 27 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 11091 | -0.667 | -0.5718 | Yes |
| 28 | DMC1 | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 11164 | -0.685 | -0.5645 | Yes |
| 29 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 11293 | -0.724 | -0.5606 | Yes |
| 30 | HIST1H4F | HIST1H4F Entrez, Source | histone cluster 1, H4f | 11324 | -0.732 | -0.5494 | Yes |
| 31 | RAD51C | RAD51C Entrez, Source | RAD51 homolog C (S. cerevisiae) | 11378 | -0.747 | -0.5396 | Yes |
| 32 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 11464 | -0.772 | -0.5317 | Yes |
| 33 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 11467 | -0.772 | -0.5177 | Yes |
| 34 | MLH3 | MLH3 Entrez, Source | mutL homolog 3 (E. coli) | 11568 | -0.799 | -0.5104 | Yes |
| 35 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 11614 | -0.812 | -0.4988 | Yes |
| 36 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 11620 | -0.813 | -0.4843 | Yes |
| 37 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 11662 | -0.826 | -0.4722 | Yes |
| 38 | HIST1H3C | HIST1H3C Entrez, Source | histone cluster 1, H3c | 11700 | -0.836 | -0.4597 | Yes |
| 39 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 11752 | -0.851 | -0.4478 | Yes |
| 40 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 11753 | -0.852 | -0.4323 | Yes |
| 41 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 11864 | -0.888 | -0.4240 | Yes |
| 42 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 11912 | -0.903 | -0.4110 | Yes |
| 43 | HIST3H3 | HIST3H3 Entrez, Source | histone cluster 3, H3 | 11980 | -0.927 | -0.3989 | Yes |
| 44 | HIST1H2BM | HIST1H2BM Entrez, Source | histone cluster 1, H2bm | 11993 | -0.930 | -0.3828 | Yes |
| 45 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 12011 | -0.935 | -0.3670 | Yes |
| 46 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 12051 | -0.951 | -0.3525 | Yes |
| 47 | MSH5 | MSH5 Entrez, Source | mutS homolog 5 (E. coli) | 12090 | -0.965 | -0.3376 | Yes |
| 48 | HIST1H4A | HIST1H4A Entrez, Source | histone cluster 1, H4a | 12181 | -1.002 | -0.3258 | Yes |
| 49 | HIST1H3F | HIST1H3F Entrez, Source | histone cluster 1, H3f | 12289 | -1.045 | -0.3145 | Yes |
| 50 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 12383 | -1.082 | -0.3015 | Yes |
| 51 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 12394 | -1.088 | -0.2824 | Yes |
| 52 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 12419 | -1.099 | -0.2641 | Yes |
| 53 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 12448 | -1.111 | -0.2458 | Yes |
| 54 | HIST1H2AD | HIST1H2AD Entrez, Source | histone cluster 1, H2ad | 12471 | -1.123 | -0.2269 | Yes |
| 55 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 12586 | -1.179 | -0.2137 | Yes |
| 56 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12692 | -1.226 | -0.1989 | Yes |
| 57 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 12705 | -1.235 | -0.1772 | Yes |
| 58 | HIST1H2AJ | HIST1H2AJ Entrez, Source | histone cluster 1, H2aj | 12817 | -1.290 | -0.1617 | Yes |
| 59 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 12862 | -1.324 | -0.1407 | Yes |
| 60 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 13190 | -1.598 | -0.1353 | Yes |
| 61 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 13453 | -1.932 | -0.1190 | Yes |
| 62 | HIST2H3C | HIST2H3C Entrez, Source | histone cluster 2, H3c | 13476 | -1.964 | -0.0847 | Yes |
| 63 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 13658 | -2.369 | -0.0546 | Yes |
| 64 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 13867 | -3.883 | 0.0012 | Yes |
