Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | data_collapsed_to_symbols.class.cls #4hr_versus_0hr.class.cls #4hr_versus_0hr_repos |
| Phenotype | class.cls#4hr_versus_0hr_repos |
| Upregulated in class | 4hr |
| GeneSet | ST_FAS_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.44954398 |
| Normalized Enrichment Score (NES) | 1.7214289 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.1981983 |
| FWER p-Value | 0.445 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 8 | 4.549 | 0.0741 | Yes |
| 2 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 98 | 3.658 | 0.1278 | Yes |
| 3 | RIPK1 | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 119 | 3.562 | 0.1848 | Yes |
| 4 | NFKBIB | NFKBIB Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 302 | 2.991 | 0.2208 | Yes |
| 5 | NFKBIE | NFKBIE Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 434 | 2.713 | 0.2559 | Yes |
| 6 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 460 | 2.661 | 0.2978 | Yes |
| 7 | DEDD2 | DEDD2 Entrez, Source | death effector domain containing 2 | 901 | 2.065 | 0.2999 | Yes |
| 8 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 925 | 2.048 | 0.3318 | Yes |
| 9 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 1016 | 1.957 | 0.3574 | Yes |
| 10 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 1080 | 1.898 | 0.3841 | Yes |
| 11 | BAX | BAX Entrez, Source | BCL2-associated X protein | 1267 | 1.728 | 0.3990 | Yes |
| 12 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 1372 | 1.630 | 0.4182 | Yes |
| 13 | CASP10 | CASP10 Entrez, Source | caspase 10, apoptosis-related cysteine peptidase | 1741 | 1.357 | 0.4139 | Yes |
| 14 | PFN2 | PFN2 Entrez, Source | profilin 2 | 1795 | 1.333 | 0.4320 | Yes |
| 15 | NFKBIL1 | NFKBIL1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 1861 | 1.302 | 0.4487 | Yes |
| 16 | FAF1 | FAF1 Entrez, Source | Fas (TNFRSF6) associated factor 1 | 2114 | 1.164 | 0.4495 | Yes |
| 17 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2652 | 0.928 | 0.4259 | No |
| 18 | NFAT5 | NFAT5 Entrez, Source | nuclear factor of activated T-cells 5, tonicity-responsive | 2780 | 0.890 | 0.4314 | No |
| 19 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 2857 | 0.863 | 0.4401 | No |
| 20 | TNFRSF6B | TNFRSF6B Entrez, Source | tumor necrosis factor receptor superfamily, member 6b, decoy | 3744 | 0.631 | 0.3863 | No |
| 21 | BFAR | BFAR Entrez, Source | bifunctional apoptosis regulator | 3901 | 0.594 | 0.3848 | No |
| 22 | CD7 | CD7 Entrez, Source | CD7 molecule | 4383 | 0.488 | 0.3581 | No |
| 23 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 4787 | 0.404 | 0.3355 | No |
| 24 | PTPN13 | PTPN13 Entrez, Source | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 4982 | 0.368 | 0.3276 | No |
| 25 | MAPK8 | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 5109 | 0.346 | 0.3241 | No |
| 26 | MAPK8IP3 | MAPK8IP3 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 3 | 5154 | 0.339 | 0.3265 | No |
| 27 | MAPK8IP1 | MAPK8IP1 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 1 | 5370 | 0.298 | 0.3159 | No |
| 28 | RALBP1 | RALBP1 Entrez, Source | ralA binding protein 1 | 6093 | 0.182 | 0.2667 | No |
| 29 | MAPK8IP2 | MAPK8IP2 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 2 | 6425 | 0.130 | 0.2449 | No |
| 30 | EPHB2 | EPHB2 Entrez, Source | EPH receptor B2 | 6841 | 0.064 | 0.2159 | No |
| 31 | TUFM | TUFM Entrez, Source | Tu translation elongation factor, mitochondrial | 7108 | 0.023 | 0.1970 | No |
| 32 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 7460 | -0.029 | 0.1721 | No |
| 33 | FAIM2 | FAIM2 Entrez, Source | Fas apoptotic inhibitory molecule 2 | 8145 | -0.137 | 0.1249 | No |
| 34 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 8497 | -0.197 | 0.1028 | No |
| 35 | DIABLO | DIABLO Entrez, Source | diablo homolog (Drosophila) | 8547 | -0.206 | 0.1026 | No |
| 36 | MAP2K7 | MAP2K7 Entrez, Source | mitogen-activated protein kinase kinase 7 | 8590 | -0.212 | 0.1031 | No |
| 37 | DEDD | DEDD Entrez, Source | death effector domain containing | 8795 | -0.246 | 0.0923 | No |
| 38 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 9174 | -0.308 | 0.0701 | No |
| 39 | DAXX | DAXX Entrez, Source | death-associated protein 6 | 9576 | -0.373 | 0.0472 | No |
| 40 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 9767 | -0.405 | 0.0401 | No |
| 41 | SMPD1 | SMPD1 Entrez, Source | sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) | 9890 | -0.428 | 0.0383 | No |
| 42 | NR0B2 | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 10060 | -0.457 | 0.0336 | No |
| 43 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 10625 | -0.558 | 0.0020 | No |
| 44 | PARP1 | PARP1 Entrez, Source | poly (ADP-ribose) polymerase family, member 1 | 10814 | -0.600 | -0.0017 | No |
| 45 | PFN1 | PFN1 Entrez, Source | profilin 1 | 11174 | -0.689 | -0.0164 | No |
| 46 | TPX2 | TPX2 Entrez, Source | TPX2, microtubule-associated, homolog (Xenopus laevis) | 11311 | -0.729 | -0.0143 | No |
| 47 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 11729 | -0.846 | -0.0305 | No |
| 48 | BAK1 | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 11849 | -0.882 | -0.0246 | No |
| 49 | CAD | CAD Entrez, Source | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 12044 | -0.948 | -0.0231 | No |
| 50 | MAP3K5 | MAP3K5 Entrez, Source | mitogen-activated protein kinase kinase kinase 5 | 12313 | -1.055 | -0.0251 | No |
| 51 | CDK2AP1 | CDK2AP1 Entrez, Source | CDK2-associated protein 1 | 12397 | -1.088 | -0.0133 | No |
| 52 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 12519 | -1.145 | -0.0032 | No |
| 53 | ALG2 | ALG2 Entrez, Source | asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase) | 12650 | -1.211 | 0.0073 | No |
| 54 | CASP8AP2 | CASP8AP2 Entrez, Source | CASP8 associated protein 2 | 13490 | -1.985 | -0.0208 | No |
| 55 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 13797 | -2.993 | 0.0062 | No |
