Details for gene set REACTOME_TOLL_RECEPTOR_CASCADES[GSEA]

Table: GSEA Results Summary

Dataset	normalized_counts_per_kilobase_for_GSEA_1.class_1.cls #AHRR-overexpressed_versus_Control
Phenotype	class_1.cls#AHRR-overexpressed_versus_Control
Upregulated in class	AHRR-overexpressed
GeneSet	REACTOME_TOLL_RECEPTOR_CASCADES
Enrichment Score (ES)	0.46048227
Normalized Enrichment Score (NES)	1.5007476
Nominal p-value	0.0
FDR q-value	0.6296902
FWER p-Value	1.0

Fig 1: Enrichment plot: REACTOME_TOLL_RECEPTOR_CASCADES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TLR8	na			405	3.124	0.0453	Yes
2	LGMN	na			413	2.979	0.1098	Yes
3	S100A12	na			463	2.493	0.1614	Yes
4	CD14	na			511	2.272	0.2083	Yes
5	LY96	na			512	2.263	0.2577	Yes
6	S100B	na			541	2.121	0.3023	Yes
7	TLR10	na			635	1.808	0.3365	Yes
8	LBP	na			1130	1.129	0.3332	Yes
9	LY86	na			1363	0.951	0.3409	Yes
10	RPS6KA2	na			1385	0.940	0.3602	Yes
11	HSP90B1	na			1521	0.860	0.3713	Yes
12	TLR5	na			1534	0.856	0.3893	Yes
13	JUN	na			1588	0.825	0.4043	Yes
14	MAP2K6	na			1757	0.745	0.4111	Yes
15	DUSP6	na			1811	0.720	0.4238	Yes
16	NOD2	na			2026	0.641	0.4257	Yes
17	CTSB	na			2027	0.641	0.4397	Yes
18	TLR4	na			2191	0.590	0.4434	Yes
19	PELI1	na			2298	0.561	0.4496	Yes
20	TLR7	na			2388	0.537	0.4563	Yes
21	ECSIT	na			2531	0.503	0.4593	Yes
22	APP	na			2710	0.461	0.4593	Yes
23	TLR6	na			2883	0.424	0.4588	Yes
24	AGER	na			3104	0.382	0.4547	Yes
25	IKBKE	na			3148	0.375	0.4605	Yes
26	MYD88	na			3321	0.345	0.4583	No
27	PELI3	na			3481	0.325	0.4564	No
28	TLR1	na			3585	0.311	0.4574	No
29	MAP2K2	na			4215	0.245	0.4273	No
30	BTK	na			4332	0.233	0.4258	No
31	PPP2R1A	na			4433	0.226	0.4251	No
32	CD180	na			4483	0.222	0.4272	No
33	RIPK1	na			4519	0.219	0.4300	No
34	DUSP4	na			4988	0.186	0.4077	No
35	PLCG2	na			5027	0.183	0.4095	No
36	MAP2K1	na			5369	0.163	0.3938	No
37	CNPY3	na			5383	0.162	0.3966	No
38	RPS6KA3	na			5552	0.151	0.3905	No
39	NFKBIB	na			5743	0.139	0.3828	No
40	SIGIRR	na			6304	0.106	0.3535	No
41	PPP2R5D	na			6356	0.103	0.3529	No
42	UBA52	na			6492	0.095	0.3473	No
43	MAP2K4	na			6697	0.085	0.3377	No
44	TICAM1	na			6709	0.084	0.3389	No
45	RELA	na			6799	0.080	0.3356	No
46	RPS6KA1	na			6879	0.076	0.3328	No
47	RIPK2	na			7161	0.062	0.3183	No
48	PPP2CA	na			7305	0.056	0.3115	No
49	IRAK4	na			7331	0.054	0.3113	No
50	IKBKG	na			7342	0.054	0.3119	No
51	TIRAP	na			7467	0.048	0.3059	No
52	IRAK1	na			7711	0.037	0.2930	No
53	DNM2	na			7737	0.036	0.2924	No
54	FOS	na			8125	0.019	0.2710	No
55	MAPK1	na			8426	0.004	0.2542	No
56	CHUK	na			8441	0.004	0.2535	No
57	TAB3	na			8661	-0.006	0.2413	No
58	MAPK3	na			8739	-0.009	0.2371	No
59	HMGB1	na			8843	-0.014	0.2316	No
60	IRF3	na			8872	-0.015	0.2303	No
61	DUSP3	na			8892	-0.016	0.2296	No
62	MAP3K7	na			9049	-0.022	0.2213	No
63	CTSS	na			9221	-0.029	0.2123	No
64	CREB1	na			9319	-0.034	0.2076	No
65	PIK3C3	na			9374	-0.036	0.2053	No
66	PPP2CB	na			9654	-0.050	0.1907	No
67	UNC93B1	na			9757	-0.054	0.1861	No
68	MAPK7	na			10143	-0.073	0.1660	No
69	MAP2K7	na			10176	-0.074	0.1658	No
70	PIK3R4	na			10263	-0.079	0.1627	No
71	ATF1	na			10461	-0.087	0.1535	No
72	PPP2R1B	na			10612	-0.095	0.1471	No
73	TRAF6	na			10829	-0.106	0.1372	No
74	MAP2K3	na			11064	-0.117	0.1265	No
75	ELK1	na			11193	-0.124	0.1220	No
76	MEF2C	na			11243	-0.126	0.1220	No
77	MAPK14	na			11305	-0.129	0.1214	No
78	ATF2	na			11331	-0.130	0.1228	No
79	NOD1	na			11644	-0.146	0.1084	No
80	NFKBIA	na			11856	-0.159	0.1000	No
81	UBE2N	na			12068	-0.170	0.0918	No
82	MAPK9	na			12109	-0.172	0.0933	No
83	DNM1	na			12260	-0.181	0.0888	No
84	RPS27A	na			12562	-0.200	0.0761	No
85	TBK1	na			12672	-0.208	0.0745	No
86	IKBKB	na			12722	-0.211	0.0764	No
87	MEF2A	na			13012	-0.230	0.0651	No
88	RPS6KA5	na			13023	-0.231	0.0696	No
89	MAPKAPK2	na			13182	-0.241	0.0659	No
90	CDK1	na			13206	-0.242	0.0699	No
91	MAPK8	na			13225	-0.244	0.0742	No
92	TLR9	na			13599	-0.270	0.0590	No
93	NFKB2	na			13618	-0.271	0.0639	No
94	TRAF3	na			13893	-0.297	0.0550	No
95	EEA1	na			14109	-0.318	0.0498	No
96	TAB2	na			14448	-0.355	0.0385	No
97	TAB1	na			14450	-0.355	0.0462	No
98	TLR2	na			14895	-0.411	0.0301	No
99	IRAK3	na			14973	-0.424	0.0350	No
100	MAPKAPK3	na			15030	-0.432	0.0413	No
101	PELI2	na			15183	-0.452	0.0425	No
102	MAPK11	na			15731	-0.564	0.0240	No
103	MAP3K1	na			15877	-0.593	0.0287	No
104	TLR3	na			15920	-0.603	0.0395	No
105	CTSK	na			16002	-0.623	0.0485	No
106	IRF7	na			16135	-0.659	0.0555	No
107	IRAK2	na			16410	-0.749	0.0564	No
108	DUSP7	na			17076	-1.114	0.0431	No

Fig 2: REACTOME_TOLL_RECEPTOR_CASCADES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_TOLL_RECEPTOR_CASCADES: Random ES distribution   
Gene set null distribution of ES for REACTOME_TOLL_RECEPTOR_CASCADES