Details for gene set REACTOME_COMPLEMENT_CASCADE[GSEA]

Table: GSEA Results Summary

Dataset	RPKM_matrix___PanKO_vs_ClusterKO.RPKM_matrix___PanKO_vs_ClusterKO.cls #PanKO_versus_ClusterKO
Phenotype	RPKM_matrix___PanKO_vs_ClusterKO.cls#PanKO_versus_ClusterKO
Upregulated in class	ClusterKO
GeneSet	REACTOME_COMPLEMENT_CASCADE
Enrichment Score (ES)	-0.5606923
Normalized Enrichment Score (NES)	-1.3965703
Nominal p-value	0.028901733
FDR q-value	1.0
FWER p-Value	0.763

Fig 1: Enrichment plot: REACTOME_COMPLEMENT_CASCADE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	SYMBOL	TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	Ighv1-78	na	1237	0.439	-0.0109	No
2	Clu	na	1709	0.390	-0.0095	No
3	C1s2	na	1838	0.379	-0.0022	No
4	C5ar1	na	1853	0.378	0.0072	No
5	Ighv3-8	na	2054	0.362	0.0127	No
6	Cfi	na	2606	0.323	0.0111	No
7	Ighv5-6	na	2732	0.316	0.0168	No
8	Igkv14-100	na	2891	0.305	0.0217	No
9	Igkv1-133	na	2921	0.303	0.0289	No
10	Cfb	na	2955	0.301	0.0359	No
11	C8a	na	3090	0.293	0.0409	No
12	Ighv1-47	na	3355	0.279	0.0433	No
13	Ighv1-81	na	3671	0.263	0.0443	No
14	Cpn1	na	3778	0.258	0.0489	No
15	Ighv4-1	na	4388	0.228	0.0438	No
16	Ighv1-34	na	4498	0.223	0.0475	No
17	Ighv1-49	na	4611	0.218	0.0510	No
18	Igkv14-126	na	4847	0.208	0.0521	No
19	Cpb2	na	4939	0.205	0.0557	No
20	C8b	na	5205	0.193	0.0558	No
21	Vtn	na	5349	0.189	0.0580	No
22	Fcnb	na	5881	0.169	0.0529	No
23	Ighv1-4	na	6116	0.160	0.0527	No
24	Mbl2	na	6294	0.154	0.0535	No
25	Ighv1-12	na	6489	0.147	0.0537	No
26	Ighv1-75	na	6656	0.140	0.0543	No
27	Ighv5-9-1	na	6807	0.135	0.0551	No
28	Ighv1-77	na	6818	0.134	0.0583	No
29	Ighv8-12	na	7212	0.122	0.0544	No
30	Ighv1-82	na	7337	0.118	0.0551	No
31	Ighv1-66	na	7887	0.099	0.0479	No
32	Elane	na	7987	0.095	0.0485	No
33	C6	na	8126	0.090	0.0483	No
34	C9	na	8282	0.085	0.0477	No
35	Ighv1-20	na	8436	0.080	0.0470	No
36	C7	na	8585	0.078	0.0463	No
37	Serping1	na	8903	0.068	0.0424	No
38	Ighv8-6	na	9099	0.061	0.0405	No
39	Cd81	na	9134	0.060	0.0414	No
40	Gzmm	na	9342	0.054	0.0391	No
41	Ighv3-4	na	9564	0.048	0.0364	No
42	C1ra	na	9599	0.048	0.0370	No
43	Ighv1-84	na	9827	0.041	0.0340	No
44	Ighv1-31	na	9830	0.041	0.0349	No
45	C3ar1	na	10225	0.030	0.0287	No
46	Ighv1-37	na	10431	0.025	0.0257	No
47	Ighv3-6	na	10555	0.022	0.0241	No
48	Igkv13-84	na	10733	0.018	0.0214	No
49	F2	na	10855	0.016	0.0196	No
50	Ighv12-3	na	11086	0.012	0.0158	No
51	C3	na	11227	0.010	0.0136	No
52	Ighv11-1	na	12444	0.000	-0.0081	No
53	Ighv8-2	na	13356	0.000	-0.0243	No
54	Igkv2-137	na	13595	0.000	-0.0285	No
55	Ighv5-12-4	na	14234	0.000	-0.0398	No
56	Ighv1-71	na	14940	0.000	-0.0524	No
57	Ighv1-69	na	15259	0.000	-0.0580	No
58	Ighv1-24	na	15495	0.000	-0.0622	No
59	Igkv1-35	na	16127	0.000	-0.0734	No
60	Igkv20-101-2	na	19795	0.000	-0.1387	No
61	Igkv1-132	na	22200	0.000	-0.1814	No
62	Ighv8-9	na	23076	0.000	-0.1970	No
63	Ighv5-2	na	25533	0.000	-0.2407	No
64	Ighv1-23	na	26362	0.000	-0.2554	No
65	Ighv3-3	na	26603	0.000	-0.2597	No
66	Ighv8-4	na	29013	0.000	-0.3026	No
67	Ighv1-16	na	30525	0.000	-0.3294	No
68	Igkv1-131	na	30783	0.000	-0.3340	No
69	Ighv8-11	na	30840	0.000	-0.3350	No
70	Ighv1-62-3	na	33034	0.000	-0.3740	No
71	Ighv1-43	na	35620	0.000	-0.4200	No
72	Ighv1-62-2	na	35630	0.000	-0.4202	No
73	Ighv15-2	na	36431	0.000	-0.4344	No
74	Igkv18-36	na	37299	0.000	-0.4498	No
75	Ighv8-13	na	40280	-0.009	-0.5026	No
76	Igll1	na	40390	-0.010	-0.5043	No
77	Crp	na	40412	-0.010	-0.5044	No
78	Ighv1-63	na	41544	-0.024	-0.5239	No
79	Ighv1-22	na	42049	-0.033	-0.5320	No
80	Igkv2-112	na	42099	-0.034	-0.5320	No
81	Ighv1-19	na	42200	-0.036	-0.5329	No
82	Ighv1-50	na	42626	-0.045	-0.5393	No
83	Ighv14-4	na	42645	-0.046	-0.5385	No
84	Ighv1-67	na	42863	-0.051	-0.5411	No
85	Hc	na	42954	-0.053	-0.5413	No
86	Masp2	na	43019	-0.054	-0.5411	No
87	Ighv5-15	na	43083	-0.056	-0.5408	No
88	Ighv11-2	na	43366	-0.063	-0.5442	No
89	Igkv13-85	na	43384	-0.063	-0.5429	No
90	Igkv1-99	na	43414	-0.064	-0.5418	No
91	Ighv1-36	na	43437	-0.065	-0.5406	No
92	Igkv14-130	na	43438	-0.065	-0.5390	No
93	Ighv1-80	na	43919	-0.078	-0.5455	No
94	Ighv1-72	na	44135	-0.084	-0.5472	No
95	Ighv1-61	na	44215	-0.086	-0.5465	No
96	Ighv1-15	na	44602	-0.099	-0.5508	No
97	Ighv1-52	na	44646	-0.100	-0.5491	No
98	Ighv5-12	na	44824	-0.106	-0.5496	No
99	Igkv12-98	na	44982	-0.110	-0.5496	No
100	Ighv1-58	na	45156	-0.115	-0.5498	No
101	Igkv1-122	na	45581	-0.127	-0.5541	No
102	Cr1l	na	45953	-0.139	-0.5572	Yes
103	Masp1	na	46151	-0.145	-0.5570	Yes
104	C1qb	na	46226	-0.148	-0.5546	Yes
105	Ighv8-5	na	46514	-0.158	-0.5557	Yes
106	Ighv1-42	na	46671	-0.163	-0.5544	Yes
107	C4b	na	46911	-0.170	-0.5543	Yes
108	Ighv1-5	na	47105	-0.176	-0.5533	Yes
109	C1qa	na	47149	-0.177	-0.5496	Yes
110	Ighv14-1	na	47718	-0.197	-0.5547	Yes
111	Ighv5-16	na	47792	-0.200	-0.5510	Yes
112	Ighv3-1	na	48124	-0.211	-0.5515	Yes
113	Ighv1-76	na	48309	-0.218	-0.5493	Yes
114	Ighv1-64	na	48434	-0.222	-0.5459	Yes
115	Igkv17-121	na	48602	-0.227	-0.5432	Yes
116	Igkv1-110	na	48759	-0.234	-0.5400	Yes
117	Igkv1-88	na	48780	-0.234	-0.5345	Yes
118	C8g	na	49246	-0.253	-0.5364	Yes
119	C1qc	na	49525	-0.263	-0.5347	Yes
120	Ighg1	na	49529	-0.263	-0.5281	Yes
121	Ighv1-59	na	49845	-0.277	-0.5267	Yes
122	Cfhr4	na	49850	-0.277	-0.5198	Yes
123	Ighv1-85	na	50119	-0.288	-0.5173	Yes
124	Ighv1-9	na	50597	-0.307	-0.5180	Yes
125	Ighv5-9	na	50739	-0.313	-0.5126	Yes
126	Cpn2	na	50842	-0.318	-0.5064	Yes
127	Ighv14-3	na	50911	-0.321	-0.4995	Yes
128	Ighv1-56	na	51342	-0.341	-0.4985	Yes
129	Ighv1-11	na	52141	-0.378	-0.5032	Yes
130	Ighv1-26	na	52434	-0.394	-0.4984	Yes
131	Ighv1-53	na	52683	-0.410	-0.4925	Yes
132	Cfp	na	53106	-0.436	-0.4890	Yes
133	Igkv8-21	na	53261	-0.445	-0.4805	Yes
134	Cfd	na	53313	-0.448	-0.4701	Yes
135	C2	na	53500	-0.461	-0.4618	Yes
136	Ighg3	na	53659	-0.471	-0.4527	Yes
137	Igkv14-111	na	53864	-0.486	-0.4441	Yes
138	Ighv1-74	na	54031	-0.498	-0.4345	Yes
139	Cd59b	na	54122	-0.506	-0.4233	Yes
140	Cfhr1	na	54179	-0.511	-0.4114	Yes
141	Igkv1-117	na	54198	-0.512	-0.3988	Yes
142	Ighv1-39	na	54524	-0.542	-0.3909	Yes
143	Igkv1-135	na	54590	-0.549	-0.3782	Yes
144	C5ar2	na	54623	-0.553	-0.3648	Yes
145	Igkv15-103	na	54677	-0.557	-0.3517	Yes
146	Fcna	na	54695	-0.560	-0.3378	Yes
147	Igkv17-127	na	54746	-0.566	-0.3245	Yes
148	Cd55	na	54801	-0.572	-0.3110	Yes
149	Ighg2c	na	55013	-0.598	-0.2996	Yes
150	Ighv1-55	na	55149	-0.616	-0.2865	Yes
151	Ighv14-2	na	55219	-0.625	-0.2719	Yes
152	Ighv1-7	na	55505	-0.667	-0.2602	Yes
153	Ighv8-8	na	55616	-0.689	-0.2447	Yes
154	Ighv1-54	na	55706	-0.709	-0.2284	Yes
155	Iglc2	na	55832	-0.744	-0.2118	Yes
156	Cr2	na	55949	-0.775	-0.1943	Yes
157	Ighv5-4	na	56089	-0.829	-0.1759	Yes
158	Ighv1-18	na	56150	-0.862	-0.1552	Yes
159	Colec11	na	56191	-0.893	-0.1334	Yes
160	Cd46	na	56241	-0.953	-0.1102	Yes
161	Iglc1	na	56251	-0.970	-0.0859	Yes
162	Cd19	na	56327	-1.112	-0.0591	Yes
163	Colec10	na	56342	-1.167	-0.0299	Yes
164	Ighv5-17	na	56355	-1.208	0.0004	Yes

Fig 2: REACTOME_COMPLEMENT_CASCADE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: REACTOME_COMPLEMENT_CASCADE: Random ES distribution   
Gene set null distribution of ES for REACTOME_COMPLEMENT_CASCADE