An official website of the United States government
The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Resources
Data and Peer Reviewed Publications
Data
The data obtained from the Interlaboratory study are available in text and Excel file formats in a zip file and can be downloaded via the NTP CEBS data page. This also includes the results of the standardized DTT analysis including BMC analysis.
To cite these data, please use the following citation:
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) Dose Range Finding (DRF) data DOI: 10.22427/NTP-DATA-002-00102-0001-000-6.
Primary Literature
Hamm, J., Hsieh, J.-H., Roberts, G., Collins, B., Gorospe, J., Sparrow, B., Walker, N.J., Truong, L., Tanguay, R.L., Dyballa, S., Miñana, R., Schiavone, V., Terriente, J., Weiner, A., Muriana, A., Quevedo, C., Ryan, K.R., 2024. Interlaboratory Study on Zebrafish in Toxicology: Systematic Evaluation of the Application of Zebrafish in Toxicology’s (SEAZIT’s) Evaluation of Developmental Toxicity. Toxics 12, 93. 10.3390/toxics12010093
Hsieh, J.-H., Nolte, S., Hamm, J.T., Wang, Z., Roberts, G.K., Schmitt, C.P., Ryan, K.R., 2023. Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Developing a Data Analysis Pipeline for the Assessment of Developmental Toxicity with an Interlaboratory Study. Toxics 11, 407. 10.3390/toxics11050407
Supportive Literature
Hsieh, J.-H., Behl, M., Parham, F., Ryan, K., 2022. Exploring the Influence of Experimental Design on Toxicity Outcomes in Zebrafish Embryo Tests. Toxicological Sciences 188, 198–207. 10.1093/toxsci/kfac053
Thessen, A.E., Marvel, S., Achenbach, J.C., Fischer, S., Haendel, M.A., Hayward, K., Klüver, N., Könemann, S., Legradi, J., Lein, P., Leong, C., Mylroie, J.E., Padilla, S., Perone, D., Planchart, A., Prieto, R.M., Muriana, A., Quevedo, C., Reif, D., Ryan, K., Stinckens, E., Truong, L., Vergauwen, L., Vom Berg, C., Wilbanks, M., Yaghoobi, B., Hamm, J., 2022. Implementation of Zebrafish Ontologies for Toxicology Screening. Frontiers in Toxicology 4. 10.3389/ftox.2022.817999
Hsieh, J.-H., Ryan, K., Sedykh, A., Lin, J.-A., Shapiro, A.J., Parham, F., Behl, M., 2019. Application of Benchmark Concentration (BMC) Analysis on Zebrafish Data: A New Perspective for Quantifying Toxicity in Alternative Animal Models. Toxicol Sci 167, 92–104. 10.1093/toxsci/kfy258
Hamm, J.T., Ceger, P., Allen, D., Stout, M., Maull, E.A., Baker, G., Zmarowski, A., Padilla, S., Perkins, E., Planchart, A., Stedman, D., Tal, T., Tanguay, R.L., Volz, D.C., Wilbanks, M.S., Walker, N.J., 2019. Characterizing sources of variability in zebrafish embryo screening protocols. ALTEX 36, 103–120. 10.14573/altex.1804162
The Team
Kristen Ryan, PhD, DABT
Toxicologist, Staff Scientist, Division of Translational Toxicology, NIEHS
Lead, Project Design and Interpretation
kristen.ryan@nih.gov
Georgia Roberts, PhD, DABT
Toxicologist, Staff Scientist, Division of Translational Toxicology, NIEHS
Contract Support & Data Interpretation
georgia.roberts@nih.gov
Jon Hamm, PhD
Contractor, Inotiv
Project Design and Data Integration
jonathan.hamm@inotivco.com
Jui-Hua Hsieh, PhD
Computational Toxicologist, Division of Translational Toxicology, NIEHS
Data Analyst, Application Design and Development
jui-hua.hsieh@nih.gov
Sue Nolte
Contractor, Office of Data Science, NIEHS
Application Full Cycle Development
sue.nolte@nih.gov
Zicong Wang
Contractor, Office of Data Science, NIEHS
Software Developer and Application Deployment
zicong.wang@nih.gov
Skylar Marvel, PhD
Contractor, Division of Translational Toxicology, NIEHS
Application Development
skylar.marvel@nih.gov
Bridgett Hill, MS
Contractor, Inotiv
Data Management and Data Curation
bridgett.hill@inotivco.com